Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56150 |
Resumo: | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. |
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Bagno, Flávia FonsecaAndrade, Luis Adan FloresSérgio, Sarah A RParise, Pierina LorenciniTeixeira, Daniel Augusto de ToledoGazzinelli, Ricardo TostesFernandes, Ana Paula Salles MouraTeixeira, Santuza Maria RibeiroGranja, FabianaMódena, José Luiz ProençaFonseca, Flavio Guimarães da2022-12-22T11:23:26Z2022-12-22T11:23:26Z2022BAGNO, Flávia Fonseca. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine. Viruses, v. 14, n. 3, 510, 2022. doi: 10.3390/v14030510.1999-4915https://www.arca.fiocruz.br/handle/icict/56150engMDPIPrevious Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil.Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil.Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil.Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil.Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil/Biodiversity Research Center. Federal University of Roraima. Boa Vista, RO, Brazil.Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil/Experimental Medicine Research Cluster. State University of Campinas. Campinas, SP, Brazil.Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil.Previous studies have indicated that antibody responses can be robustly induced after the vaccination in individuals previously infected by SARS-CoV-2. To evaluate anti-SARS-CoV-2 humoral responses in vaccinated individuals with or without a previous history of COVID-19, we compared levels of anti-SARS-CoV-2 antibodies in the sera from 21 vaccinees, including COVID-19-recovered or -naïve individuals in different times, before and after immunization with an inactivated COVID-19 vaccine. Anti-SARS-CoV-2-specific antibodies elicited after COVID-19 and/or immunization with an inactivated vaccine were measured by ELISA and Plaque Reduction Neutralizing assays. Antibody kinetics were consistently different between the two vaccine doses for naïve individuals, contrasting with the SARS-CoV-2-recovered subjects in which we observed no additional increase in antibody levels following the second dose. Sera from SARS-CoV2-naïve individuals had no detectable neutralizing activity against lineage B.1 SARS-CoV-2 or Gamma variant five months after the second vaccine dose. Contrarily, SARS-CoV-2-recovered subjects retained considerable neutralizing activity against both viruses. We conclude that a single inactivated SARS-CoV-2 vaccine dose may be sufficient to induce protective antibody responses in individuals with previous history of SARS-CoV-2 infection.COVID-19CoronaVacELISAPRNTantibodiesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56150/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPrevious Infection with SARS-CoV-2 Correlates.pdfPrevious Infection with SARS-CoV-2 Correlates.pdfapplication/pdf2283118https://www.arca.fiocruz.br/bitstream/icict/56150/2/Previous%20Infection%20with%20SARS-CoV-2%20Correlates.pdfa8c190bbc46b2021d224f78412907bb2MD52icict/561502022-12-22 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| dc.title.en_US.fl_str_mv |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| title |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| spellingShingle |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine Bagno, Flávia Fonseca COVID-19 CoronaVac ELISA PRNT antibodies |
| title_short |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| title_full |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| title_fullStr |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| title_full_unstemmed |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| title_sort |
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine |
| author |
Bagno, Flávia Fonseca |
| author_facet |
Bagno, Flávia Fonseca Andrade, Luis Adan Flores Sérgio, Sarah A R Parise, Pierina Lorencini Teixeira, Daniel Augusto de Toledo Gazzinelli, Ricardo Tostes Fernandes, Ana Paula Salles Moura Teixeira, Santuza Maria Ribeiro Granja, Fabiana Módena, José Luiz Proença Fonseca, Flavio Guimarães da |
| author_role |
author |
| author2 |
Andrade, Luis Adan Flores Sérgio, Sarah A R Parise, Pierina Lorencini Teixeira, Daniel Augusto de Toledo Gazzinelli, Ricardo Tostes Fernandes, Ana Paula Salles Moura Teixeira, Santuza Maria Ribeiro Granja, Fabiana Módena, José Luiz Proença Fonseca, Flavio Guimarães da |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bagno, Flávia Fonseca Andrade, Luis Adan Flores Sérgio, Sarah A R Parise, Pierina Lorencini Teixeira, Daniel Augusto de Toledo Gazzinelli, Ricardo Tostes Fernandes, Ana Paula Salles Moura Teixeira, Santuza Maria Ribeiro Granja, Fabiana Módena, José Luiz Proença Fonseca, Flavio Guimarães da |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 CoronaVac ELISA PRNT antibodies |
| topic |
COVID-19 CoronaVac ELISA PRNT antibodies |
| description |
Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. |
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2022 |
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2022-12-22T11:23:26Z |
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2022-12-22T11:23:26Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BAGNO, Flávia Fonseca. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine. Viruses, v. 14, n. 3, 510, 2022. doi: 10.3390/v14030510. |
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https://www.arca.fiocruz.br/handle/icict/56150 |
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1999-4915 |
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BAGNO, Flávia Fonseca. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine. Viruses, v. 14, n. 3, 510, 2022. doi: 10.3390/v14030510. 1999-4915 |
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MDPI |
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