IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.

Detalhes bibliográficos
Autor(a) principal: Zarife, Maria Alice Sant’Anna
Data de Publicação: 2011
Outros Autores: Reis, Eliana Almeida Gomes, Meira, Glenda C, Carmo, Theomira Mauadie de Azevedo, Lopes, Gisele Barreto, Malafaia, Emilia C. O. B, Silva, Helder Reis, Santana, Nelma Pereira de, Martins Filho, Olindo Assis, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7500
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública, LACEN-BA. Salvador, BA, Brasil
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spelling Zarife, Maria Alice Sant’AnnaReis, Eliana Almeida GomesMeira, Glenda CCarmo, Theomira Mauadie de AzevedoLopes, Gisele BarretoMalafaia, Emilia C. O. BSilva, Helder ReisSantana, Nelma Pereira deMartins Filho, Olindo AssisReis, Mitermayer Galvão dos2014-04-07T17:40:22Z2014-04-07T17:40:22Z2011IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.1423-010010.1159/000318896https://www.arca.fiocruz.br/handle/icict/7500engS Karger AG BrasilIL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública, LACEN-BA. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHEMOBA. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThe aim of this study was to explore a possible association between the pattern of serum cytokines with the virological and biochemical status of hepatitis C virus (HCV)-seropositive blood donors. METHODS: 23 non-viremic and 33 viremic HCV-seropositive blood donors based on HCV-RNA tests, and 29 healthy individuals were included. Cytometric bead array assays were performed to detect cytokines. RESULTS: The subjects were classified as low, medium or high cytokine producers based on the tertile distribution. The absence of detectable viremia was associated with high IL-1ß and IL-8 producers. Conversely, elevated levels of IL-6, IL-10 and IL-12 were associated with detectable viremia. An increased frequency of high IL-1ß producers was observed frequently in the non-viremic recombinant immunoblot assay (RIBA)-indeterminate subjects, while the high IL-4, IL-6, IL-8, IL-10 and IL-12 producers were more frequent in the non-viremic RIBA-positive subjects. Furthermore, the levels of IL-1ß and IL-8 were higher in viremic subjects with a low level of alanine-aminotransferase (ALT), whereas the level of IFN-γ was increased among viremic subjects with a high ALT level. CONCLUSION: IL-1ß and IL-8 were more likely to be associated with a non-viremic or less severe HCV infection, whereas IL-2 and IFN-γ levels correlated with a high ALT level.Hepatitis C virusBlood donorsInflammatory and regulatoryCytokinesSerological statusVirological statusAlanine aminotransferaseDoadores de SangueHepacivirus/isolamento & purificaçãoHepatite C/diagnósticoHepatite C/virologiaInterferon gama/sangueInterleucina-8/sangueViremia/diagnósticoAdultoFemininoHepacivirus/imunologiaHepatite C/imunologiaHumanosMasculinoMeia-IdadeRNA Viral/sangueinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALZarife MAS IL-8 Is....pdfZarife MAS IL-8 Is....pdfapplication/pdf276780https://www.arca.fiocruz.br/bitstream/icict/7500/1/Zarife%20MAS%20IL-8%20Is....pdf0bd198d3622fa3b87ccc090449c5c117MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7500/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTZarife MAS IL-8 Is....pdf.txtZarife MAS IL-8 Is....pdf.txtExtracted texttext/plain37726https://www.arca.fiocruz.br/bitstream/icict/7500/5/Zarife%20MAS%20IL-8%20Is....pdf.txt9b50eeb88f7ade3100d8efbb80964569MD55THUMBNAILZarife MAS IL-8 Is....pdf.jpgZarife MAS IL-8 Is....pdf.jpgGenerated Thumbnailimage/jpeg2207https://www.arca.fiocruz.br/bitstream/icict/7500/4/Zarife%20MAS%20IL-8%20Is....pdf.jpg92004e9df5e9ce4287e8ae8b6e8b490eMD54icict/75002023-03-15 14:33:17.905oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
title IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
spellingShingle IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
Zarife, Maria Alice Sant’Anna
Hepatitis C virus
Blood donors
Inflammatory and regulatory
Cytokines
Serological status
Virological status
Alanine aminotransferase
Doadores de Sangue
Hepacivirus/isolamento & purificação
Hepatite C/diagnóstico
Hepatite C/virologia
Interferon gama/sangue
Interleucina-8/sangue
Viremia/diagnóstico
Adulto
Feminino
Hepacivirus/imunologia
Hepatite C/imunologia
Humanos
Masculino
Meia-Idade
RNA Viral/sangue
title_short IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
title_full IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
title_fullStr IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
title_full_unstemmed IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
title_sort IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
author Zarife, Maria Alice Sant’Anna
author_facet Zarife, Maria Alice Sant’Anna
Reis, Eliana Almeida Gomes
Meira, Glenda C
Carmo, Theomira Mauadie de Azevedo
Lopes, Gisele Barreto
Malafaia, Emilia C. O. B
Silva, Helder Reis
Santana, Nelma Pereira de
Martins Filho, Olindo Assis
Reis, Mitermayer Galvão dos
author_role author
author2 Reis, Eliana Almeida Gomes
Meira, Glenda C
Carmo, Theomira Mauadie de Azevedo
Lopes, Gisele Barreto
Malafaia, Emilia C. O. B
Silva, Helder Reis
Santana, Nelma Pereira de
Martins Filho, Olindo Assis
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zarife, Maria Alice Sant’Anna
Reis, Eliana Almeida Gomes
Meira, Glenda C
Carmo, Theomira Mauadie de Azevedo
Lopes, Gisele Barreto
Malafaia, Emilia C. O. B
Silva, Helder Reis
Santana, Nelma Pereira de
Martins Filho, Olindo Assis
Reis, Mitermayer Galvão dos
dc.subject.en.pt_BR.fl_str_mv Hepatitis C virus
Blood donors
Inflammatory and regulatory
Cytokines
Serological status
Virological status
Alanine aminotransferase
topic Hepatitis C virus
Blood donors
Inflammatory and regulatory
Cytokines
Serological status
Virological status
Alanine aminotransferase
Doadores de Sangue
Hepacivirus/isolamento & purificação
Hepatite C/diagnóstico
Hepatite C/virologia
Interferon gama/sangue
Interleucina-8/sangue
Viremia/diagnóstico
Adulto
Feminino
Hepacivirus/imunologia
Hepatite C/imunologia
Humanos
Masculino
Meia-Idade
RNA Viral/sangue
dc.subject.decs.pt_BR.fl_str_mv Doadores de Sangue
Hepacivirus/isolamento & purificação
Hepatite C/diagnóstico
Hepatite C/virologia
Interferon gama/sangue
Interleucina-8/sangue
Viremia/diagnóstico
Adulto
Feminino
Hepacivirus/imunologia
Hepatite C/imunologia
Humanos
Masculino
Meia-Idade
RNA Viral/sangue
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública, LACEN-BA. Salvador, BA, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-04-07T17:40:22Z
dc.date.available.fl_str_mv 2014-04-07T17:40:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7500
dc.identifier.issn.none.fl_str_mv 1423-0100
10.1159/000318896
identifier_str_mv IL-8 is associated with non-viremic state and IFN-γ with biochemical activity in HCV-seropositive blood donors.
1423-0100
10.1159/000318896
url https://www.arca.fiocruz.br/handle/icict/7500
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv S Karger AG Brasil
publisher.none.fl_str_mv S Karger AG Brasil
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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