Revisão sistemática: efeitos do citrato de maropitant como analgésico em cães e gatos

• Autor(a) principal: Basilio, Beatriz Cristina Contente
• Data de Publicação: 2021
• Outros Autores: Kubis, Gabriela Menine
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/3311
• topic: Analgesia; Antagonista receptor neurocinina-1; Dor; Substância P; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA

Citrate of Maropitant is an NK-1 receptor antagonist, blocking the activity of substance P in the center of vomiting and in the chemoreceptor trigger zone. Another beneficial effect observed with the use of the NK-1 receptor antagonist is the reduction of inhaled anesthetics in anesthetic maintenance of dogs and cats. Current veterinary medicine recommends multimodal analgesia, which consists of administering analgesics with different mechanisms of action on the pain pathways, so that a dose of each can be reduced, analgesic effects maximized, as well as reduced side effects. This work aims to evaluate whether maropitant citrate has analgesic effects on dogs and cats. For this, a retrospective electronic survey was carried out between the years 2010 and 2020, using a PubMed database. The consultation was conducted with the following keywords: analgesia, dogs, cats, maropitant citrate, cerenia, maropitant, minimum alveolar concentration, neurokinin 1 receptor, neurokinin-1 antagonist and Substance P. A limited to articles written in English and Portuguese, adopting as an inclusion criterion the canine and feline population that underwent some procedure where maropitant was used as an analgesic adjuvant. It is concluded that maropitant remains the requirement for inhaled anesthetics, however the decrease in the need for analgesic rescue in the postoperative period, greater comfort in the postoperative period and the real analgesic effect of maropitant as an analgesic adjuvant needs more standardized studies than to be compared