O uso de células tronco no tratamento do trauma raquimedular:uma revisão
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Repositório do Centro Universitário Braz Cubas |
| Texto Completo: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/2595 |
Resumo: | The spinal cord injury is a condition where the individual loses partially or totally the motor capacity and it is still affected by systemic complications. Being the permanent treatment for the long-term paralysis undefined these patients has a cost to public health. With the technological and medical advances has been found a great potential in the use of stem cells for the treatment of this type of injury. The availability of multiple sources of adult mesenchymal cells suggests innovative and promising strategies but the research should be conducted with caution because of the little knowledge on some tumor modulations and the real effectiveness. As in any research for advances and setbacks, it is necessary expand the knowledge about whether these cells actually fulfill their therapeutic promise and which will be suitable for many different diseases. In this review, we will briefly discuss the mechanism and pathophysiology of spinal cord injury and potential sources of adult mesenchymal stem cells and their response to treatment with cell therapy in this specific group. |
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O uso de células tronco no tratamento do trauma raquimedular:uma revisãoCélulas-troncoMedula ósseaTrauma raquimedularCNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERALThe spinal cord injury is a condition where the individual loses partially or totally the motor capacity and it is still affected by systemic complications. Being the permanent treatment for the long-term paralysis undefined these patients has a cost to public health. With the technological and medical advances has been found a great potential in the use of stem cells for the treatment of this type of injury. The availability of multiple sources of adult mesenchymal cells suggests innovative and promising strategies but the research should be conducted with caution because of the little knowledge on some tumor modulations and the real effectiveness. As in any research for advances and setbacks, it is necessary expand the knowledge about whether these cells actually fulfill their therapeutic promise and which will be suitable for many different diseases. In this review, we will briefly discuss the mechanism and pathophysiology of spinal cord injury and potential sources of adult mesenchymal stem cells and their response to treatment with cell therapy in this specific group.O trauma raquimedular é uma condição onde o indivíduo perde parcialmente ou totalmente a capacidade motora e ainda é acometido por complicações sistêmicas, sendo o tratamento para a paralisia permanente indefinido. A longo prazo estes pacientes têm um custo para a saúde pública. Com os avanços tecnológicos e médicos está sendo encontrado um potencial grande no uso das células-tronco para este tipo de grupo. A disponibilidade de várias fontes de células mesenquimais adultas sugere estratégias inovadoras e promissoras. Porém, as pesquisas devem ser realizadas com cautela devido ao pouco conhecimento sobre algumas modulações tumorais e sobre a real eficácia do tratamento. Deve-se, portanto, ampliar o conhecimento sobre se estas células realmente cumpririam sua promessa terapêutica e quais serão adequadas para as mais diferentes doenças. Nesta revisão vamos discutir brevemente o mecanismo e fisiopatologia das lesões medulares e eficácia do uso de células-tronco de medula óssea e suas respostas ao tratamento com terapia celular neste grupo específico.Universidade PositivoBrasilPós-GraduaçãoPrograma de Pós-Graduação em Biotecnologia IndustrialUPPincerati, Márciahttp://lattes.cnpq.br/1632493068360047Ramos, Camila da Silva Barbosa2021-08-17T18:38:09Z20152021-08-17T18:38:09Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/2595porinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-08-23T17:19:28Zoai:repositorio.cruzeirodosul.edu.br:123456789/2595Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-08-23T17:19:28Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
| dc.title.none.fl_str_mv |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| title |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| spellingShingle |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão Ramos, Camila da Silva Barbosa Células-tronco Medula óssea Trauma raquimedular CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
| title_short |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| title_full |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| title_fullStr |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| title_full_unstemmed |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| title_sort |
O uso de células tronco no tratamento do trauma raquimedular:uma revisão |
| author |
Ramos, Camila da Silva Barbosa |
| author_facet |
Ramos, Camila da Silva Barbosa |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
Pincerati, Márcia http://lattes.cnpq.br/1632493068360047 |
| dc.contributor.author.fl_str_mv |
Ramos, Camila da Silva Barbosa |
| dc.subject.por.fl_str_mv |
Células-tronco Medula óssea Trauma raquimedular CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
| topic |
Células-tronco Medula óssea Trauma raquimedular CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
| description |
The spinal cord injury is a condition where the individual loses partially or totally the motor capacity and it is still affected by systemic complications. Being the permanent treatment for the long-term paralysis undefined these patients has a cost to public health. With the technological and medical advances has been found a great potential in the use of stem cells for the treatment of this type of injury. The availability of multiple sources of adult mesenchymal cells suggests innovative and promising strategies but the research should be conducted with caution because of the little knowledge on some tumor modulations and the real effectiveness. As in any research for advances and setbacks, it is necessary expand the knowledge about whether these cells actually fulfill their therapeutic promise and which will be suitable for many different diseases. In this review, we will briefly discuss the mechanism and pathophysiology of spinal cord injury and potential sources of adult mesenchymal stem cells and their response to treatment with cell therapy in this specific group. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015 2021-08-17T18:38:09Z 2021-08-17T18:38:09Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/2595 |
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https://repositorio.cruzeirodosul.edu.br/handle/123456789/2595 |
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por |
| language |
por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Biotecnologia Industrial UP |
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Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Biotecnologia Industrial UP |
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reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
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Centro Universitário Braz Cubas (CUB) |
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CUB |
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CUB |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
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bibli@brazcubas.edu.br |
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