Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal

Detalhes bibliográficos
Autor(a) principal: Fernandes, Ana Amélia M. de L.
Data de Publicação: 2020
Outros Autores: Almeida, Cássia C. de, Silva, Larissa V. da
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório do Centro Universitário Braz Cubas
Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/1132
Resumo: Celiac disease (CD) is a systemic disorder and immune-mediated by gluten in genetically susceptible individuals. IgA antibodies against tissue transglutaminase (tTG IgA) are sensitive markers used in laboratory diagnosis of CD. Currently, there are two methods used for the diagnosis of CD, serology analyzing IgA antibodies against transglutaminase, and intestinal biopsy. The article explores the protocol adopted since 2012 by the Association of American and European Gastroenterologists (ESPGHAN) that demonstrates that it is possible to evidence CD without subjecting the patient to invasive processes, such as biopsy. We analyzed 11 articles published between 1999 and 2018, in which the results reveal that it is still not possible to rule out the biopsy in some cases, especially when there is a clinical picture and IgA anti-transglutaminase antibodies less than 10 times higher than the cutoff point (cutoff). With these results, we can infer that more sensitive and more specific serological tests are still necessary to completely rule out the use of biopsy as a method of clinical diagnosis of CD.
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spelling Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinalAnti-transglutaminase IgADoença celíacaDiagnóstico laboratorialImunoensaioAutoimunidade4.03.00.00-5 FarmáciaCeliac disease (CD) is a systemic disorder and immune-mediated by gluten in genetically susceptible individuals. IgA antibodies against tissue transglutaminase (tTG IgA) are sensitive markers used in laboratory diagnosis of CD. Currently, there are two methods used for the diagnosis of CD, serology analyzing IgA antibodies against transglutaminase, and intestinal biopsy. The article explores the protocol adopted since 2012 by the Association of American and European Gastroenterologists (ESPGHAN) that demonstrates that it is possible to evidence CD without subjecting the patient to invasive processes, such as biopsy. We analyzed 11 articles published between 1999 and 2018, in which the results reveal that it is still not possible to rule out the biopsy in some cases, especially when there is a clinical picture and IgA anti-transglutaminase antibodies less than 10 times higher than the cutoff point (cutoff). With these results, we can infer that more sensitive and more specific serological tests are still necessary to completely rule out the use of biopsy as a method of clinical diagnosis of CD.Agência 1A doença celíaca (DC) é uma desordem sistêmica e imunomediada por glúten em indivíduos geneticamente suscetíveis. Os anticorpos IgA contra transglutaminase tecidual (tTG IgA) são marcadores sensíveis empregados no diagnóstico laboratorial da DC. Atualmente, existem duas maneiras empregadas para o diagnóstico de DC, a sorologia analisando anticorpos IgA contra a transglutaminase, e biópsia intestinal. O artigo explora o protocolo adotado desde 2012 pela Associação de Gastroenterologistas Americanos e Europeus (ESPGHAN) que demonstra ser possível evidenciar a DC sem submeter o paciente a processos invasivos, como é o caso da biópsia. Foram analisados 11 artigos publicados entre 1999 e 2018, no qual os resultados revelam que ainda não é possível descartar a biópsia em alguns casos, especialmente quando existe quadro clínico e anticorpos antitransglutaminase IgA menores do que 10 vezes mais alto que o ponto de corte (cutoff). Com estes resultados, podemos inferir que ainda são necessários testes sorológicos mais sensíveis e mais específicos para poder descartar completamente a utilização da biópsia como método de diagnóstico clínico da DC.Centro de Ensino Unificado do Distrito FederalBrasilCoordenação do Curso de FarmáciaUDFROCHA, Ana Carolina Alves4177114060065370http://lattes.cnpq.br/4177114060065370Fernandes, Ana Amélia M. de L.Almeida, Cássia C. deSilva, Larissa V. da2020-11-27T17:06:55Z2020-11-272020-11-27T17:06:55Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/1132porARAYA M. & BASCUÑÁN K. Enfermedad celíaca. Una mirada actual. Revista Chilena de Pediatría - Noviembre - Diciembre 2014. BONAMICO, M. et al. Patchy villous atrophy of the duodenum in childhood celiac disease. Journal of Pediatric Gastroenterology and Nutrition, v. 38, n. 2, p. 204 - 7, 2004. BONAMICO, M.; THANASI, E.; MARIANI, P. Duodenal bulb biopsies in celiac disease: a multicenter study. Journal of Pediatric Gastroenterology and Nutrition, v. 47, n. 5, p. 618 - 622, 2008. CATALDO, F. et al. Prevalence and clinical features of selective imunologlobulin A deficiency in coeliac disease: an Italian multicentre stydy. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and "Club del Tenue" Working Groups on Coeliac Disease, v. 42, n. 3, p. 362 - 65, 1998. CATASSI C. & FASANO A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med 2010; 123: 691–3. COLLIN, P. et al. Endocrinological disorders and celiac disease. Endocr Rev, v. 23, n. 4, p. 464 - 83, 2002. DANDALIDES, S. et al. Endoscopic small bowel mucosal biopsy: a controlled trial evaluating forceps size and biopsy location in the diagnosis of normal and abnormal mucosal architecture. Gastrointestinal Endoscopy, v. 35, n. 3, p. 197 - 200, 1989. GREEN, P. H.; ROSTAMI, K.; MARSH, M. N. Diagnosis of coeliac disease. Best Pract Res Clin Gastroenterology, v. 19, n. 3, p. 389-400, Jun 2005. GREEN, P.; CELLIER, C. Celiac disease. New England Journal of Medicine, v. 357, n. 17, p. 1731 - 43, 2007. HILL, D. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, v. 40, n. 1, p. 1 - 19, 2005. HUSBY, S. et al. European Society for Pediatric Gastroenterology, Hepatology (ESPGHAN), and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr, v. 54, n. 1, p. 136-60, Jan 2012. LIU S. M. et. al. Doença Celíaca. Rev Med Minas Gerais 2014; 24 (Supl 2): S38-S45. LUDVIGSSON J. F. BAI J.C., BIAGI F, et al. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut 2014;63:1210–1228. MARSH, M. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology, v. 102, n. 1, p. 330 - 54, 1992. MEE, A. et al. Small bowel biopsy for malabsorption: comparison of the diagnostic adequacy of endoscopic forceps and capsule biopsy specimens. British Medical Journal (Clinical Research Ed.) - NCBI, v. 291, n. 6498, p. 769 - 72, 1985. OBERHUBER, B.; GRANDITSCH, G.; VOGELSANG, H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. European Journal of Gastroenterology & Hepatology, v. 11, n. 10, p. 1185 - 94, 1999. OLASO X. R., GOSSWEILER C. O., GONZÁLEZ V. L. Uso de nuevas técnicas y procedimientos endoscópicos en diagnóstico y seguimiento de la enfermedad celíaca. Rev. urug. med. interna. Marzo 2018 N°1: 3-14. PEDRO N. et. al. Doença Celíaca – revisão de conceitos e novos desenvolvimentos. Medicina Interna, fevereiro 2008. REILLY, N. R. et al. Coeliac disease: to biopsy or not? Nat Rev Gastroenterol Hepatol, v. 15, n. 1, p. 60 - 66, janeiro 2018. REWERS, M. et al. Celiac disease associated whit type 1 diabetes mellitus. Endocrinol Metab Clin N Am, v. 33, n. 1, p. 197 - 214, março 2004. ROCHA, A. C. A.; NÓBREGA, Y. K. M. Comparação de metodologias analíticaslaboratoriais para dosagem de anti-transglutaminase IgA utilizada no diagnóstico sorológico da doença celíaca. Dissertação de mestrado. Universidade de Brasília, 2016. ROSTAMI, K. et al. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. The American Journal of Gastroenterology, v. 94, n. 4, p. 888 - 94, 1999. SDEPANIAN V.L., MORAIS M.B., NETO U.F. Doença celíaca: a evolução dos conhecimentos desde sua centenária descrição original até os dias atuais. Arq Gastroenterol V. 36 - no. 4 - out/dez. 1999. SILVA, T. S. D. G.; FURLANETTO, T. W. Diagnóstico de doença celíaca em adultos. Nat Rev Gastroenterol Hepatol, Porto Alegre, v. 56, n. 1, p. 122 - 126, 2010. WGO. World Gastroenterology Organisation Global. WGO Guidelines. Doença Celíaca. Abril, 2012.info:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-01-29T21:08:16Zoai:repositorio.cruzeirodosul.edu.br:123456789/1132Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-01-29T21:08:16Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false
dc.title.none.fl_str_mv Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
title Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
spellingShingle Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
Fernandes, Ana Amélia M. de L.
Anti-transglutaminase IgA
Doença celíaca
Diagnóstico laboratorial
Imunoensaio
Autoimunidade
4.03.00.00-5 Farmácia
title_short Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
title_full Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
title_fullStr Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
title_full_unstemmed Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
title_sort Diagnóstico sorológico da doença celíaca visando a diminuição da biópsia intestinal
author Fernandes, Ana Amélia M. de L.
author_facet Fernandes, Ana Amélia M. de L.
Almeida, Cássia C. de
Silva, Larissa V. da
author_role author
author2 Almeida, Cássia C. de
Silva, Larissa V. da
author2_role author
author
dc.contributor.none.fl_str_mv ROCHA, Ana Carolina Alves
4177114060065370
http://lattes.cnpq.br/4177114060065370
dc.contributor.author.fl_str_mv Fernandes, Ana Amélia M. de L.
Almeida, Cássia C. de
Silva, Larissa V. da
dc.subject.por.fl_str_mv Anti-transglutaminase IgA
Doença celíaca
Diagnóstico laboratorial
Imunoensaio
Autoimunidade
4.03.00.00-5 Farmácia
topic Anti-transglutaminase IgA
Doença celíaca
Diagnóstico laboratorial
Imunoensaio
Autoimunidade
4.03.00.00-5 Farmácia
description Celiac disease (CD) is a systemic disorder and immune-mediated by gluten in genetically susceptible individuals. IgA antibodies against tissue transglutaminase (tTG IgA) are sensitive markers used in laboratory diagnosis of CD. Currently, there are two methods used for the diagnosis of CD, serology analyzing IgA antibodies against transglutaminase, and intestinal biopsy. The article explores the protocol adopted since 2012 by the Association of American and European Gastroenterologists (ESPGHAN) that demonstrates that it is possible to evidence CD without subjecting the patient to invasive processes, such as biopsy. We analyzed 11 articles published between 1999 and 2018, in which the results reveal that it is still not possible to rule out the biopsy in some cases, especially when there is a clinical picture and IgA anti-transglutaminase antibodies less than 10 times higher than the cutoff point (cutoff). With these results, we can infer that more sensitive and more specific serological tests are still necessary to completely rule out the use of biopsy as a method of clinical diagnosis of CD.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-27T17:06:55Z
2020-11-27
2020-11-27T17:06:55Z
2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.cruzeirodosul.edu.br/handle/123456789/1132
url https://repositorio.cruzeirodosul.edu.br/handle/123456789/1132
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv ARAYA M. & BASCUÑÁN K. Enfermedad celíaca. Una mirada actual. Revista Chilena de Pediatría - Noviembre - Diciembre 2014. BONAMICO, M. et al. Patchy villous atrophy of the duodenum in childhood celiac disease. Journal of Pediatric Gastroenterology and Nutrition, v. 38, n. 2, p. 204 - 7, 2004. BONAMICO, M.; THANASI, E.; MARIANI, P. Duodenal bulb biopsies in celiac disease: a multicenter study. Journal of Pediatric Gastroenterology and Nutrition, v. 47, n. 5, p. 618 - 622, 2008. CATALDO, F. et al. Prevalence and clinical features of selective imunologlobulin A deficiency in coeliac disease: an Italian multicentre stydy. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and "Club del Tenue" Working Groups on Coeliac Disease, v. 42, n. 3, p. 362 - 65, 1998. CATASSI C. & FASANO A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med 2010; 123: 691–3. COLLIN, P. et al. Endocrinological disorders and celiac disease. Endocr Rev, v. 23, n. 4, p. 464 - 83, 2002. DANDALIDES, S. et al. Endoscopic small bowel mucosal biopsy: a controlled trial evaluating forceps size and biopsy location in the diagnosis of normal and abnormal mucosal architecture. Gastrointestinal Endoscopy, v. 35, n. 3, p. 197 - 200, 1989. GREEN, P. H.; ROSTAMI, K.; MARSH, M. N. Diagnosis of coeliac disease. Best Pract Res Clin Gastroenterology, v. 19, n. 3, p. 389-400, Jun 2005. GREEN, P.; CELLIER, C. Celiac disease. New England Journal of Medicine, v. 357, n. 17, p. 1731 - 43, 2007. HILL, D. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, v. 40, n. 1, p. 1 - 19, 2005. HUSBY, S. et al. European Society for Pediatric Gastroenterology, Hepatology (ESPGHAN), and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr, v. 54, n. 1, p. 136-60, Jan 2012. LIU S. M. et. al. Doença Celíaca. Rev Med Minas Gerais 2014; 24 (Supl 2): S38-S45. LUDVIGSSON J. F. BAI J.C., BIAGI F, et al. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut 2014;63:1210–1228. MARSH, M. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology, v. 102, n. 1, p. 330 - 54, 1992. MEE, A. et al. Small bowel biopsy for malabsorption: comparison of the diagnostic adequacy of endoscopic forceps and capsule biopsy specimens. British Medical Journal (Clinical Research Ed.) - NCBI, v. 291, n. 6498, p. 769 - 72, 1985. OBERHUBER, B.; GRANDITSCH, G.; VOGELSANG, H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. European Journal of Gastroenterology & Hepatology, v. 11, n. 10, p. 1185 - 94, 1999. OLASO X. R., GOSSWEILER C. O., GONZÁLEZ V. L. Uso de nuevas técnicas y procedimientos endoscópicos en diagnóstico y seguimiento de la enfermedad celíaca. Rev. urug. med. interna. Marzo 2018 N°1: 3-14. PEDRO N. et. al. Doença Celíaca – revisão de conceitos e novos desenvolvimentos. Medicina Interna, fevereiro 2008. REILLY, N. R. et al. Coeliac disease: to biopsy or not? Nat Rev Gastroenterol Hepatol, v. 15, n. 1, p. 60 - 66, janeiro 2018. REWERS, M. et al. Celiac disease associated whit type 1 diabetes mellitus. Endocrinol Metab Clin N Am, v. 33, n. 1, p. 197 - 214, março 2004. ROCHA, A. C. A.; NÓBREGA, Y. K. M. Comparação de metodologias analíticaslaboratoriais para dosagem de anti-transglutaminase IgA utilizada no diagnóstico sorológico da doença celíaca. Dissertação de mestrado. Universidade de Brasília, 2016. ROSTAMI, K. et al. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. The American Journal of Gastroenterology, v. 94, n. 4, p. 888 - 94, 1999. SDEPANIAN V.L., MORAIS M.B., NETO U.F. Doença celíaca: a evolução dos conhecimentos desde sua centenária descrição original até os dias atuais. Arq Gastroenterol V. 36 - no. 4 - out/dez. 1999. SILVA, T. S. D. G.; FURLANETTO, T. W. Diagnóstico de doença celíaca em adultos. Nat Rev Gastroenterol Hepatol, Porto Alegre, v. 56, n. 1, p. 122 - 126, 2010. WGO. World Gastroenterology Organisation Global. WGO Guidelines. Doença Celíaca. Abril, 2012.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centro de Ensino Unificado do Distrito Federal
Brasil
Coordenação do Curso de Farmácia
UDF
publisher.none.fl_str_mv Centro de Ensino Unificado do Distrito Federal
Brasil
Coordenação do Curso de Farmácia
UDF
dc.source.none.fl_str_mv reponame:Repositório do Centro Universitário Braz Cubas
instname:Centro Universitário Braz Cubas (CUB)
instacron:CUB
instname_str Centro Universitário Braz Cubas (CUB)
instacron_str CUB
institution CUB
reponame_str Repositório do Centro Universitário Braz Cubas
collection Repositório do Centro Universitário Braz Cubas
repository.name.fl_str_mv Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)
repository.mail.fl_str_mv bibli@brazcubas.edu.br
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