Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório do Centro Universitário Braz Cubas |
Texto Completo: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/3928 |
Resumo: | The gastrointestinal system is composed of a variety of cells, which can result in the development of different neoplasms, with different clinical signs and similar histomorphological characteristics, being often confused with other comorbidities, making diagnosis and treatment difficult. Given the morphological similarity between gastrointestinal stromal tumors and other sarcomas of the intestine of dogs, combined with the scarcity of studies proving the true frequency of these neoplasms, the aim of the present study was to carry out an epidemiological survey of suspected cases of gastrointestinal stromal tumors in dogs, diagnosed by histopathology and confirmed by immunohistochemistry, from the Veterinary Clinical Analysis Laboratory - VetPat (Campinas, SP), from June 2014 to December 2020, in addition to associating them with the patients' review (race, sex and age), tumor location and invasion, mitotic index and immunohistochemical markers used. The results obtained were expressed descriptively and as a percentage. A total of 217 histopathological reports were obtained and only 36 animals were included in the study that were definitively diagnosed by immunohistochemistry. The main breeds diagnosed in the gastrointestinal stromal tumors were mixed breed dogs, Dachshund, Poodle and Golden Retriever, represented mainly by elderly women, while in the other sarcomas the main affected breeds were mixed breeds and Dachshund, being males and women equally affected. The cecal region and the small intestine were the most common intestinal culminations, with tumor invasion of the intestinal layers in 31 animals and ulceration in six of them. The number of mitotic figures ranged from three to 17 figures, in 16 of 36 tumors taken. Gastrointestinal stromal tumors frequently expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas, being fundamental immunohistochemistry for determining the diagnoses. KEYWORDS: canine; CD117; DOG-1; GIST; intestine; neoplasm. |
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Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cãesEpidemiological study of gastrointestinal stromal tumors and other sarcomas that i intestine of dogsCanino - TumoresIntestinoNeoplasiaTumores estromais gastrointestinais (CD117)Proteína DOG-ITumor estromal gastrointestinal (GIST)CNPQ::CIENCIAS AGRARIAS::ZOOTECNIAThe gastrointestinal system is composed of a variety of cells, which can result in the development of different neoplasms, with different clinical signs and similar histomorphological characteristics, being often confused with other comorbidities, making diagnosis and treatment difficult. Given the morphological similarity between gastrointestinal stromal tumors and other sarcomas of the intestine of dogs, combined with the scarcity of studies proving the true frequency of these neoplasms, the aim of the present study was to carry out an epidemiological survey of suspected cases of gastrointestinal stromal tumors in dogs, diagnosed by histopathology and confirmed by immunohistochemistry, from the Veterinary Clinical Analysis Laboratory - VetPat (Campinas, SP), from June 2014 to December 2020, in addition to associating them with the patients' review (race, sex and age), tumor location and invasion, mitotic index and immunohistochemical markers used. The results obtained were expressed descriptively and as a percentage. A total of 217 histopathological reports were obtained and only 36 animals were included in the study that were definitively diagnosed by immunohistochemistry. The main breeds diagnosed in the gastrointestinal stromal tumors were mixed breed dogs, Dachshund, Poodle and Golden Retriever, represented mainly by elderly women, while in the other sarcomas the main affected breeds were mixed breeds and Dachshund, being males and women equally affected. The cecal region and the small intestine were the most common intestinal culminations, with tumor invasion of the intestinal layers in 31 animals and ulceration in six of them. The number of mitotic figures ranged from three to 17 figures, in 16 of 36 tumors taken. Gastrointestinal stromal tumors frequently expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas, being fundamental immunohistochemistry for determining the diagnoses. KEYWORDS: canine; CD117; DOG-1; GIST; intestine; neoplasm.O sistema gastrointestinal é composto por uma diversidade de células, podendo resultar no desenvolvimento de diferentes neoplasias, com variados sinais clínicos e características histomorfológicas semelhantes, sendo frequentemente confundidas com outras comorbidades, dificultando o diagnóstico e tratamento. Diante da semelhança morfológica entre os tumores estromais gastrointestinais e outros sarcomas do intestino de cães, aliado a escassez de estudos que comprovem a verdadeira frequência dessas neoplasias, o objetivo do presente estudo foi realizar levantamento epidemiológico dos casos suspeitos de tumores estromais gastrointestinais em cães, diagnosticados por histopatologia e imunohistoquímica, provenientes do Laboratório de Análises Clínicas Veterinário - VetPat (Campinas, SP), no período de junho de 2014 a dezembro de 2020, além de associá-los a resenha dos pacientes (raça, sexo e idade), localização e invasão tumoral, índice mitótico e marcadores imunohistoquímicos utilizados. Os resultados obtidos foram expressos de forma descritiva e percentual. Foram avaliados 217 laudos histopatológicos e incluídos no estudo somente 36 animas que constaram diagnóstico definitivo pela imunohistoquímica. As principais raças diagnosticadas nos tumores estromais gastrointestinais foram cães sem raça definida, Dachshund, Poodle e Golden Retriever, representados principalmente por fêmeas idosas, enquanto, nos outros sarcomas as principais raças acometidas foram sem raça definida e Dachshund, sendo machos e fêmeas igualmente acometidos. A região cecal e o intestino delgado foram as localizações intestinais mais descritas, havendo invasão tumoral das camadas intestinais em 31 animais e ulceração em seis deles. O número de figuras de mitoses variou entre três e 17 figuras, em 16 dos 36 tumores avaliados. Os tumores estromais gastrointestinais expressaram com frequência marcadores como CD117 e DOG-1, diferentemente dos outros sarcomas intestinais, sendo a imunohistoquímica fundamental para a determinação dos diagnósticos. PALAVRAS-CHAVE: canino; CD117; DOG-1; GIST; intestino; neoplasiaUniversidade de FrancaBrasilPós-GraduaçãoPrograma de Mestrado em Ciência AnimalUNIFRANDias, Fernanda Gosuen Gonçalves1764676973565426http://lattes.cnpq.br/1764676973565426Jark, Paulo César3116730932812815http://lattes.cnpq.br/3116730932812815Paulino Júnior, Daniel2992008966310276http://lattes.cnpq.br/2992008966310276Magalhães, Geórgia Modé7952251706145257http://lattes.cnpq.br/7952251706145257Costa, Marina Laudares2022-06-27T13:27:51Z2022-06-27T13:27:51Z2022-02-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfCOSTA, Marina Laudares. Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães. Franca, SP, 2022. 53 f. Dissertação (Mestrado) - Universidade de Franca. 2022https://repositorio.cruzeirodosul.edu.br/handle/123456789/3928porinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2022-06-27T13:29:16Zoai:repositorio.cruzeirodosul.edu.br:123456789/3928Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2022-06-27T13:29:16Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
dc.title.none.fl_str_mv |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães Epidemiological study of gastrointestinal stromal tumors and other sarcomas that i intestine of dogs |
title |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães |
spellingShingle |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães Costa, Marina Laudares Canino - Tumores Intestino Neoplasia Tumores estromais gastrointestinais (CD117) Proteína DOG-I Tumor estromal gastrointestinal (GIST) CNPQ::CIENCIAS AGRARIAS::ZOOTECNIA |
title_short |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães |
title_full |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães |
title_fullStr |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães |
title_full_unstemmed |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães |
title_sort |
Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães |
author |
Costa, Marina Laudares |
author_facet |
Costa, Marina Laudares |
author_role |
author |
dc.contributor.none.fl_str_mv |
Dias, Fernanda Gosuen Gonçalves 1764676973565426 http://lattes.cnpq.br/1764676973565426 Jark, Paulo César 3116730932812815 http://lattes.cnpq.br/3116730932812815 Paulino Júnior, Daniel 2992008966310276 http://lattes.cnpq.br/2992008966310276 Magalhães, Geórgia Modé 7952251706145257 http://lattes.cnpq.br/7952251706145257 |
dc.contributor.author.fl_str_mv |
Costa, Marina Laudares |
dc.subject.por.fl_str_mv |
Canino - Tumores Intestino Neoplasia Tumores estromais gastrointestinais (CD117) Proteína DOG-I Tumor estromal gastrointestinal (GIST) CNPQ::CIENCIAS AGRARIAS::ZOOTECNIA |
topic |
Canino - Tumores Intestino Neoplasia Tumores estromais gastrointestinais (CD117) Proteína DOG-I Tumor estromal gastrointestinal (GIST) CNPQ::CIENCIAS AGRARIAS::ZOOTECNIA |
description |
The gastrointestinal system is composed of a variety of cells, which can result in the development of different neoplasms, with different clinical signs and similar histomorphological characteristics, being often confused with other comorbidities, making diagnosis and treatment difficult. Given the morphological similarity between gastrointestinal stromal tumors and other sarcomas of the intestine of dogs, combined with the scarcity of studies proving the true frequency of these neoplasms, the aim of the present study was to carry out an epidemiological survey of suspected cases of gastrointestinal stromal tumors in dogs, diagnosed by histopathology and confirmed by immunohistochemistry, from the Veterinary Clinical Analysis Laboratory - VetPat (Campinas, SP), from June 2014 to December 2020, in addition to associating them with the patients' review (race, sex and age), tumor location and invasion, mitotic index and immunohistochemical markers used. The results obtained were expressed descriptively and as a percentage. A total of 217 histopathological reports were obtained and only 36 animals were included in the study that were definitively diagnosed by immunohistochemistry. The main breeds diagnosed in the gastrointestinal stromal tumors were mixed breed dogs, Dachshund, Poodle and Golden Retriever, represented mainly by elderly women, while in the other sarcomas the main affected breeds were mixed breeds and Dachshund, being males and women equally affected. The cecal region and the small intestine were the most common intestinal culminations, with tumor invasion of the intestinal layers in 31 animals and ulceration in six of them. The number of mitotic figures ranged from three to 17 figures, in 16 of 36 tumors taken. Gastrointestinal stromal tumors frequently expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas, being fundamental immunohistochemistry for determining the diagnoses. KEYWORDS: canine; CD117; DOG-1; GIST; intestine; neoplasm. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-27T13:27:51Z 2022-06-27T13:27:51Z 2022-02-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
COSTA, Marina Laudares. Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães. Franca, SP, 2022. 53 f. Dissertação (Mestrado) - Universidade de Franca. 2022 https://repositorio.cruzeirodosul.edu.br/handle/123456789/3928 |
identifier_str_mv |
COSTA, Marina Laudares. Estudo epidemiológico de tumores estromais gastrointestinais e outros sarcomas que afetam o intestino de cães. Franca, SP, 2022. 53 f. Dissertação (Mestrado) - Universidade de Franca. 2022 |
url |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/3928 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de Franca Brasil Pós-Graduação Programa de Mestrado em Ciência Animal UNIFRAN |
publisher.none.fl_str_mv |
Universidade de Franca Brasil Pós-Graduação Programa de Mestrado em Ciência Animal UNIFRAN |
dc.source.none.fl_str_mv |
reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
instname_str |
Centro Universitário Braz Cubas (CUB) |
instacron_str |
CUB |
institution |
CUB |
reponame_str |
Repositório do Centro Universitário Braz Cubas |
collection |
Repositório do Centro Universitário Braz Cubas |
repository.name.fl_str_mv |
Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
repository.mail.fl_str_mv |
bibli@brazcubas.edu.br |
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1798311360642154496 |