Etiopatogenia, clínica e terapêutica da Doença de Parkinson: uma desordem neurodegenerativa

• Autor(a) principal: Lima, Jacqueline Aparecida de
• Data de Publicação: 2019
• Outros Autores: Azevedo, Luana Cristina Diniz de, Silva, Luciana Rocha da, Rodrigues, Márcia Aparecida Pinto, Macedo, Michaela Vieira de, Vasconcelos, Renato Tresca de, Salvador, Thais Maia da Silva
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/349
• topic: Doença de Parkinson; Fisiopatologia; Levodopa; Tratamento; CNPQ::OUTROS::BIOMEDICINA

Parkinson's disease is the second most common neurodegenerative disease in the world, affecting about 10 million individuals. It is a progressive and irreversible disease characterized by the loss of dopaminergic neurons in the substantia nigra of the brain. Dopamine is an important neurotransmitter responsible for stimulating intentional movement. Degradation of these neurons causes increased excitatory signals sent to the motor control system, resulting in the main symptoms of PD such as tremors at rest, stiffness, difficulty performing daily tasks such as shaving, brushing teeth and dressing up. The causes of PD are unknown, but the evidences points to genetic causes, environmental factors, and changes in the enteric system. There is no cure, but the treatments currently used provide an improvement in quality of life and increased longevity. The main treatments used, levodopa, dopaminergic agonists, and deep brain stimulation surgery. Diagnosis is usually made based on symptoms, but imaging can be performed to confirm the diagnosis. In this work, a bibliographic review about the pathophysiology, symptoms and treatments of Parkinson's Disease was performed.