Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório do Centro Universitário Braz Cubas |
Texto Completo: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/684 |
Resumo: | The spinal cord has an important role in the mechanism of transmission of nociceptive impulses. The block of these impulses interrupt or minimize the pain derived from the release of inflammatory mediators harmful to the body. Thus, administration of drugs in this region has been used both for anesthetic blocks and for prevention of postoperative pain. This study aimed to evaluate the analgesic and time effects of dexmedetomidine with lidocaine, administered epidurally, during the postoperative period in female dogs underwent to ovariohysterectomy (OHE). For this purpose it was used 20 adult female dogs, healthy, separated into two groups. In GLIDO group it was applied epidurally 0.25 ml/kg of 2% lidocaine without vasoconstrictor associated with sodium chloride 0.9%, and in GDEX group it was administered lidocaine without vasoconstrictor, in the same dose, associated with 2 μg/kg of dexmedetomidine. The surgeon was the same in all procedures and evaluation began in the postoperative period immediately after extubation and every 30 minutes during six hours. It was evaluated objective and subjective parameters: visual analogue scale (VAS), behavioral scale, heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic arterial pressure (SAP) and the time of additional analgesia required. For HR, GLIDO was significantly higher than GDEX in T0 and T30. Respiratory rate was different between groups only 60 minutes after the beginning of the evaluation, and GLIDO was higher than GDEX. In addition, T300 was higher than T0 in GDEX. RT increased gradually throughout the evaluation period in GDEX. In the analgesic evaluation thought behavioral table and visual analogue scale higher scores were observed in GDLIDO when compared to GDEX, with significant difference in VAS at T0, T30, and T90, representing more pronounced response to pain. The analgesia in GLIDO animals lasted 150 minutes and in GDEX 360 minutes. It was concluded that dexmedetomidine associated with lidocaine epidurally is a secure technique, with better quality of anesthesia recovery and longer postoperative analgesia. |
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Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomiaClinical and analgesic effects of epidural administration of dexmedetomidine associated with lidocaine in bitches undergoing ovary-hysterectomyCadelaDorAgonista-receptor-alfa-2-adrenérgicoCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMALThe spinal cord has an important role in the mechanism of transmission of nociceptive impulses. The block of these impulses interrupt or minimize the pain derived from the release of inflammatory mediators harmful to the body. Thus, administration of drugs in this region has been used both for anesthetic blocks and for prevention of postoperative pain. This study aimed to evaluate the analgesic and time effects of dexmedetomidine with lidocaine, administered epidurally, during the postoperative period in female dogs underwent to ovariohysterectomy (OHE). For this purpose it was used 20 adult female dogs, healthy, separated into two groups. In GLIDO group it was applied epidurally 0.25 ml/kg of 2% lidocaine without vasoconstrictor associated with sodium chloride 0.9%, and in GDEX group it was administered lidocaine without vasoconstrictor, in the same dose, associated with 2 μg/kg of dexmedetomidine. The surgeon was the same in all procedures and evaluation began in the postoperative period immediately after extubation and every 30 minutes during six hours. It was evaluated objective and subjective parameters: visual analogue scale (VAS), behavioral scale, heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic arterial pressure (SAP) and the time of additional analgesia required. For HR, GLIDO was significantly higher than GDEX in T0 and T30. Respiratory rate was different between groups only 60 minutes after the beginning of the evaluation, and GLIDO was higher than GDEX. In addition, T300 was higher than T0 in GDEX. RT increased gradually throughout the evaluation period in GDEX. In the analgesic evaluation thought behavioral table and visual analogue scale higher scores were observed in GDLIDO when compared to GDEX, with significant difference in VAS at T0, T30, and T90, representing more pronounced response to pain. The analgesia in GLIDO animals lasted 150 minutes and in GDEX 360 minutes. It was concluded that dexmedetomidine associated with lidocaine epidurally is a secure technique, with better quality of anesthesia recovery and longer postoperative analgesia.A medula espinhal tem importante papel no mecanismo de transmissão dos impulsos nervosos nociceptivos. O bloqueio desses impulsos interrompe ou minimiza a dor derivada da liberação de mediadores inflamatórios deletérios ao organismo. Assim, a administração de fármacos nesta região tem sido empregada tanto para a realização de bloqueios anestésicos, quanto para a prevenção da dor pósoperatória. Nesse sentido, esse trabalho teve por objetivo avaliar o efeito e o tempo analgésico da dexmedetomidina associada à lidocaína, administradas pela via epidural, durante o período pós-cirúrgico em cadelas submetidas à ováriohisterectomia (OHE). Para tanto, foram utilizadas 22 cadelas adultas, hígidas, distribuídas em dois grupos, sendo que no GLIDO foi aplicada por via epidural 4 mg/kg de lidocaína a 2% sem vasoconstrictor, e no GDEX administrou-se a lidocaína sem vasoconstrictor, na mesma dose, associada à 2 µg/kg de dexmedetomidina pela mesma via. Em ambos os grupos, o volume total da solução para administração epidural foi completado com solução salina e ajustado para 0,3 ml/kg. A avaliação iniciou-se no período pós-operatório imediatamente após extubação e a cada 30 minutos durante seis horas. Foram mensurados parâmetros objetivos e subjetivos, sendo eles: escala visual analógica (EVA), escala comportamental, frequência cardíaca (FC), frequência respiratória (ƒ), temperatura retal (TR), pressão arterial sistólica (PAS) e momento necessário da analgesia resgate. Em relação a FC o GLIDO foi significativamente maior que GDEX no T0 e T30. Já a f apresentou diferença entre grupos somente 60 minutos após o início da avaliação, sendo o GLIDO maior que o GDEX. A TR aumentou gradativamente ao longo do período de avaliação no GDEX. Na avaliação da analgesia pela tabela comportamental e pela escala visual analógica observaram-se maiores escores no GLIDO quando comparado ao GDEX, com diferença significativa na EVA no T0, T30 e T90, representando desta forma resposta mais pronunciada a dor. O período máximo de analgesia nos animais do GLIDO foi de 150 minutos e no GDEX de 360 minutos. Os resultados permitiram concluir que a dexmedetomidina associada à lidocaína pela via epidural, demonstrou ser uma associação segura, com recuperação anestésica de melhor qualidade e duração da analgesia pós-operatória mais prolongada.Universidade de FrancaBrasilPós-GraduaçãoPrograma de Mestrado em Medicina Veterinária de Pequenos AnimaisUNIFRANNishimori, Celina Tie Duque9867050564803302http://lattes.cnpq.br/9867050564803302Marquetti, Mércia Amaro2020-05-20T15:37:54Z2020-05-20T15:37:54Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfMARQUETTI, Mércia Amaro. Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia. Franca, 2011. 41 f. Dissertação (Mestrado em Medicina Veterinária de Pequenos Animais) - Universidade de Franca. 2011.https://repositorio.cruzeirodosul.edu.br/handle/123456789/684porinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2020-05-20T15:39:27Zoai:repositorio.cruzeirodosul.edu.br:123456789/684Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2020-05-20T15:39:27Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
dc.title.none.fl_str_mv |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia Clinical and analgesic effects of epidural administration of dexmedetomidine associated with lidocaine in bitches undergoing ovary-hysterectomy |
title |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia |
spellingShingle |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia Marquetti, Mércia Amaro Cadela Dor Agonista-receptor-alfa-2-adrenérgico CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL |
title_short |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia |
title_full |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia |
title_fullStr |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia |
title_full_unstemmed |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia |
title_sort |
Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia |
author |
Marquetti, Mércia Amaro |
author_facet |
Marquetti, Mércia Amaro |
author_role |
author |
dc.contributor.none.fl_str_mv |
Nishimori, Celina Tie Duque 9867050564803302 http://lattes.cnpq.br/9867050564803302 |
dc.contributor.author.fl_str_mv |
Marquetti, Mércia Amaro |
dc.subject.por.fl_str_mv |
Cadela Dor Agonista-receptor-alfa-2-adrenérgico CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL |
topic |
Cadela Dor Agonista-receptor-alfa-2-adrenérgico CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL |
description |
The spinal cord has an important role in the mechanism of transmission of nociceptive impulses. The block of these impulses interrupt or minimize the pain derived from the release of inflammatory mediators harmful to the body. Thus, administration of drugs in this region has been used both for anesthetic blocks and for prevention of postoperative pain. This study aimed to evaluate the analgesic and time effects of dexmedetomidine with lidocaine, administered epidurally, during the postoperative period in female dogs underwent to ovariohysterectomy (OHE). For this purpose it was used 20 adult female dogs, healthy, separated into two groups. In GLIDO group it was applied epidurally 0.25 ml/kg of 2% lidocaine without vasoconstrictor associated with sodium chloride 0.9%, and in GDEX group it was administered lidocaine without vasoconstrictor, in the same dose, associated with 2 μg/kg of dexmedetomidine. The surgeon was the same in all procedures and evaluation began in the postoperative period immediately after extubation and every 30 minutes during six hours. It was evaluated objective and subjective parameters: visual analogue scale (VAS), behavioral scale, heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic arterial pressure (SAP) and the time of additional analgesia required. For HR, GLIDO was significantly higher than GDEX in T0 and T30. Respiratory rate was different between groups only 60 minutes after the beginning of the evaluation, and GLIDO was higher than GDEX. In addition, T300 was higher than T0 in GDEX. RT increased gradually throughout the evaluation period in GDEX. In the analgesic evaluation thought behavioral table and visual analogue scale higher scores were observed in GDLIDO when compared to GDEX, with significant difference in VAS at T0, T30, and T90, representing more pronounced response to pain. The analgesia in GLIDO animals lasted 150 minutes and in GDEX 360 minutes. It was concluded that dexmedetomidine associated with lidocaine epidurally is a secure technique, with better quality of anesthesia recovery and longer postoperative analgesia. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2020-05-20T15:37:54Z 2020-05-20T15:37:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MARQUETTI, Mércia Amaro. Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia. Franca, 2011. 41 f. Dissertação (Mestrado em Medicina Veterinária de Pequenos Animais) - Universidade de Franca. 2011. https://repositorio.cruzeirodosul.edu.br/handle/123456789/684 |
identifier_str_mv |
MARQUETTI, Mércia Amaro. Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia. Franca, 2011. 41 f. Dissertação (Mestrado em Medicina Veterinária de Pequenos Animais) - Universidade de Franca. 2011. |
url |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/684 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de Franca Brasil Pós-Graduação Programa de Mestrado em Medicina Veterinária de Pequenos Animais UNIFRAN |
publisher.none.fl_str_mv |
Universidade de Franca Brasil Pós-Graduação Programa de Mestrado em Medicina Veterinária de Pequenos Animais UNIFRAN |
dc.source.none.fl_str_mv |
reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
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Centro Universitário Braz Cubas (CUB) |
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CUB |
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CUB |
reponame_str |
Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas |
repository.name.fl_str_mv |
Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
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bibli@brazcubas.edu.br |
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1798311354471284736 |