Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018000100065 |
Resumo: | ABSTRACT: Histopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive for HEV-RNA (n=13); Group 3, positive for anti-HEV IgG (n=10). Group 2 showed a significant difference among the groups for liver lesions such as lobular activity (P=0.007), periportal interface hepatitis (P=0.004), portal inflammation (P=0.028) hepatitis with lobular, portal and periportal interface activity (P=0.001). HEV detection by immunohistochemistry was performed and 3 of 6 samples of group 2 were positive. Pigs naturally infected by HEV genotype 3 present microscopic necroinflammatory liver lesions similar to HEV in humans. Liver histopathology showed be important in the diagnosis of active asymptomatic HEV infection in pigs slaughtered for human consumption because hepatic liver lesions may present distinct profiles according to molecular and serological diagnosis and in this sense, histopathology and immunohistochemistry may be an important complementary diagnostic tool. |
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Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3Liverhepatitis E virusgenotype 3hepatitishistopathologyimmunohistochemistryswinezoonosispathologyABSTRACT: Histopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive for HEV-RNA (n=13); Group 3, positive for anti-HEV IgG (n=10). Group 2 showed a significant difference among the groups for liver lesions such as lobular activity (P=0.007), periportal interface hepatitis (P=0.004), portal inflammation (P=0.028) hepatitis with lobular, portal and periportal interface activity (P=0.001). HEV detection by immunohistochemistry was performed and 3 of 6 samples of group 2 were positive. Pigs naturally infected by HEV genotype 3 present microscopic necroinflammatory liver lesions similar to HEV in humans. Liver histopathology showed be important in the diagnosis of active asymptomatic HEV infection in pigs slaughtered for human consumption because hepatic liver lesions may present distinct profiles according to molecular and serological diagnosis and in this sense, histopathology and immunohistochemistry may be an important complementary diagnostic tool.Colégio Brasileiro de Patologia Animal - CBPA2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018000100065Pesquisa Veterinária Brasileira v.38 n.1 2018reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/1678-5150-pvb-5368info:eu-repo/semantics/openAccessSouza,Alex J.S. deMalheiros,Andreza P.Soares,Manoel do C.P.Gomes-Gouvêa,Michele S.Pinho,João R.R.Pereira,Washington L.A.Sá,Lilian R.M.eng2018-04-09T00:00:00Zoai:scielo:S0100-736X2018000100065Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2018-04-09T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
title |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
spellingShingle |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 Souza,Alex J.S. de Liver hepatitis E virus genotype 3 hepatitis histopathology immunohistochemistry swine zoonosis pathology |
title_short |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
title_full |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
title_fullStr |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
title_full_unstemmed |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
title_sort |
Hallmarks of liver lesions in pigs naturally infected by hepatitis E virus genotype 3 |
author |
Souza,Alex J.S. de |
author_facet |
Souza,Alex J.S. de Malheiros,Andreza P. Soares,Manoel do C.P. Gomes-Gouvêa,Michele S. Pinho,João R.R. Pereira,Washington L.A. Sá,Lilian R.M. |
author_role |
author |
author2 |
Malheiros,Andreza P. Soares,Manoel do C.P. Gomes-Gouvêa,Michele S. Pinho,João R.R. Pereira,Washington L.A. Sá,Lilian R.M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Souza,Alex J.S. de Malheiros,Andreza P. Soares,Manoel do C.P. Gomes-Gouvêa,Michele S. Pinho,João R.R. Pereira,Washington L.A. Sá,Lilian R.M. |
dc.subject.por.fl_str_mv |
Liver hepatitis E virus genotype 3 hepatitis histopathology immunohistochemistry swine zoonosis pathology |
topic |
Liver hepatitis E virus genotype 3 hepatitis histopathology immunohistochemistry swine zoonosis pathology |
description |
ABSTRACT: Histopathological evaluation of liver from 33 pigs slaughtered for human consumption in Amazon region, previously tested by serology and molecular techniques for hepatitis E virus infection (HEV), was analysed in three groups: Group 1, negative for both HEV-RNA and anti-HEV IgG (n=10); Group 2, positive for HEV-RNA (n=13); Group 3, positive for anti-HEV IgG (n=10). Group 2 showed a significant difference among the groups for liver lesions such as lobular activity (P=0.007), periportal interface hepatitis (P=0.004), portal inflammation (P=0.028) hepatitis with lobular, portal and periportal interface activity (P=0.001). HEV detection by immunohistochemistry was performed and 3 of 6 samples of group 2 were positive. Pigs naturally infected by HEV genotype 3 present microscopic necroinflammatory liver lesions similar to HEV in humans. Liver histopathology showed be important in the diagnosis of active asymptomatic HEV infection in pigs slaughtered for human consumption because hepatic liver lesions may present distinct profiles according to molecular and serological diagnosis and in this sense, histopathology and immunohistochemistry may be an important complementary diagnostic tool. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018000100065 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018000100065 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-5150-pvb-5368 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.38 n.1 2018 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122237918576640 |