Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia

Detalhes bibliográficos
Autor(a) principal: Paraná, Raymundo
Data de Publicação: 2012
Outros Autores: Atta, Maria Luiza Brito de Sousa, Cabral, Milena Barreto de Arruda, Santos, Gilvan, Atta, Ajax Mercês
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15557
Resumo: Texto completo: acesso restrito. p. 1101-1106
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spelling Paraná, RaymundoAtta, Maria Luiza Brito de SousaCabral, Milena Barreto de ArrudaSantos, GilvanAtta, Ajax MercêsParaná, RaymundoAtta, Maria Luiza Brito de SousaCabral, Milena Barreto de ArrudaSantos, GilvanAtta, Ajax Mercês2014-08-11T19:10:18Z20121023-3830http://repositorio.ufba.br/ri/handle/ri/15557v. 61, n. 10Texto completo: acesso restrito. p. 1101-1106Objective: This work investigated the profile of inflammation biomarkers in patients with chronic hepatitis C and its association with liver fibrosis, hepatic necroinflammatory activity, viral genotypes and cryoglobulinemia. Subjects and methods: Seventy-eight untreated patients were studied. Biomarker levels were determined by immunoassays, cryoglobulinemia by cryoprecipitation and liver histopathology investigated using METAVIR scores. Results: Decreased levels of α1-acid glycoprotein (AGP), C3 and haptoglobin (Hp) were observed in the patients (P < 0.0001). Increased α1-antitrypsin (P < 0.01) and ferritin (P < 0.0001) levels were found in this group, but C-reactive protein (CRP) and C4 levels were unaltered. Alanine aminotransferase inversely correlated with Hp (P < 0.01) and AGP (P = 0.01), whereas it was directly correlated with ferritin (P < 0.05) and AGP (P < 0.0001). The levels of CRP, C3 and C4 were lower in the patients with hepatic necroinflammatory activity (P < 0.05). Patients with advanced fibrosis had low levels of Hp and AGP (P < 0.05 and P < 0.01, respectively). Neither infection with different viral genotypes nor cryoglobulinemia caused an alteration in biomarker levels. Conclusion: Chronic hepatitis C virus infection alters the levels of some biomarkers, which are mainly observed in patients with liver fibrosis and hepatic necroinflammatory activity.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-20T12:13:01Z No. of bitstreams: 1 Raymundo Paraná.pdf: 276647 bytes, checksum: 69b64c293ddda919feab717f6093f755 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-08-11T19:10:18Z (GMT) No. of bitstreams: 1 Raymundo Paraná.pdf: 276647 bytes, checksum: 69b64c293ddda919feab717f6093f755 (MD5)Made available in DSpace on 2014-08-11T19:10:18Z (GMT). No. of bitstreams: 1 Raymundo Paraná.pdf: 276647 bytes, checksum: 69b64c293ddda919feab717f6093f755 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1007/s00011-012-0502-2reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis CInflammation biomarkersLiver histopathologyViral genotypeCryoglobulinemiaInflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemiaInflammation Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALRaymundo Paraná.pdfRaymundo Paraná.pdfapplication/pdf276647https://repositorio.ufba.br/bitstream/ri/15557/1/Raymundo%20Paran%c3%a1.pdf69b64c293ddda919feab717f6093f755MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15557/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTRaymundo Paraná.pdf.txtRaymundo Paraná.pdf.txtExtracted texttext/plain24588https://repositorio.ufba.br/bitstream/ri/15557/3/Raymundo%20Paran%c3%a1.pdf.txtb843ed83d72d5f59990d287d210a898aMD53ri/155572022-07-05 14:03:32.941oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:32Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
dc.title.alternative.pt_BR.fl_str_mv Inflammation Research
title Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
spellingShingle Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
Paraná, Raymundo
Hepatitis C
Inflammation biomarkers
Liver histopathology
Viral genotype
Cryoglobulinemia
title_short Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
title_full Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
title_fullStr Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
title_full_unstemmed Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
title_sort Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
author Paraná, Raymundo
author_facet Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
Cabral, Milena Barreto de Arruda
Santos, Gilvan
Atta, Ajax Mercês
author_role author
author2 Atta, Maria Luiza Brito de Sousa
Cabral, Milena Barreto de Arruda
Santos, Gilvan
Atta, Ajax Mercês
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
Cabral, Milena Barreto de Arruda
Santos, Gilvan
Atta, Ajax Mercês
Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
Cabral, Milena Barreto de Arruda
Santos, Gilvan
Atta, Ajax Mercês
dc.subject.por.fl_str_mv Hepatitis C
Inflammation biomarkers
Liver histopathology
Viral genotype
Cryoglobulinemia
topic Hepatitis C
Inflammation biomarkers
Liver histopathology
Viral genotype
Cryoglobulinemia
description Texto completo: acesso restrito. p. 1101-1106
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-08-11T19:10:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15557
dc.identifier.issn.none.fl_str_mv 1023-3830
dc.identifier.number.pt_BR.fl_str_mv v. 61, n. 10
identifier_str_mv 1023-3830
v. 61, n. 10
url http://repositorio.ufba.br/ri/handle/ri/15557
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1007/s00011-012-0502-2
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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