Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000800753 |
Resumo: | Abstract: This study describes the development of the central nervous system in guinea pigs from 12th day post conception (dpc) until birth. Totally, 41 embryos and fetuses were analyzed macroscopically and by means of light and electron microscopy. The neural tube closure was observed at day 14 and the development of the spinal cord and differentiation of the primitive central nervous system vesicles was on 20th dpc. Histologically, undifferentiated brain tissue was observed as a mass of mesenchymal tissue between 18th and 20th dpc, and at 25th dpc the tissue within the medullary canal had higher density. On day 30 the brain tissue was differentiated on day 30 and the spinal cord filling throughout the spinal canal, period from which it was possible to observe cerebral and cerebellar stratums. At day 45 intumescences were visualized and cerebral hemispheres were divided, with a clear division between white and gray matter in brain and cerebellum. Median sulcus of the dorsal spinal cord and the cauda equina were only evident on day 50. There were no significant structural differences in fetuses of 50 and 60 dpc, and animals at term were all lissencephalic. In conclusion, morphological studies of the nervous system in guinea pig can provide important information for clinical studies in humans, due to its high degree of neurological maturity in relation to its short gestation period, what can provide a good tool for neurological studies. |
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Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)Nervous systemembryologyanimal modelshistology.Abstract: This study describes the development of the central nervous system in guinea pigs from 12th day post conception (dpc) until birth. Totally, 41 embryos and fetuses were analyzed macroscopically and by means of light and electron microscopy. The neural tube closure was observed at day 14 and the development of the spinal cord and differentiation of the primitive central nervous system vesicles was on 20th dpc. Histologically, undifferentiated brain tissue was observed as a mass of mesenchymal tissue between 18th and 20th dpc, and at 25th dpc the tissue within the medullary canal had higher density. On day 30 the brain tissue was differentiated on day 30 and the spinal cord filling throughout the spinal canal, period from which it was possible to observe cerebral and cerebellar stratums. At day 45 intumescences were visualized and cerebral hemispheres were divided, with a clear division between white and gray matter in brain and cerebellum. Median sulcus of the dorsal spinal cord and the cauda equina were only evident on day 50. There were no significant structural differences in fetuses of 50 and 60 dpc, and animals at term were all lissencephalic. In conclusion, morphological studies of the nervous system in guinea pig can provide important information for clinical studies in humans, due to its high degree of neurological maturity in relation to its short gestation period, what can provide a good tool for neurological studies.Colégio Brasileiro de Patologia Animal - CBPA2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000800753Pesquisa Veterinária Brasileira v.36 n.8 2016reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2016000800013info:eu-repo/semantics/openAccessSilva,Fernanda Menezes de Oliveira eAlcantara,DayaneCarvalho,Rafael CardosoFavaron,Phelipe OliveiraSantos,Amilton Cesar dosViana,Diego CarvalhoMiglino,Maria Angelicaeng2016-10-28T00:00:00Zoai:scielo:S0100-736X2016000800753Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2016-10-28T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
title |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
spellingShingle |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) Silva,Fernanda Menezes de Oliveira e Nervous system embryology animal models histology. |
title_short |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
title_full |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
title_fullStr |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
title_full_unstemmed |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
title_sort |
Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae) |
author |
Silva,Fernanda Menezes de Oliveira e |
author_facet |
Silva,Fernanda Menezes de Oliveira e Alcantara,Dayane Carvalho,Rafael Cardoso Favaron,Phelipe Oliveira Santos,Amilton Cesar dos Viana,Diego Carvalho Miglino,Maria Angelica |
author_role |
author |
author2 |
Alcantara,Dayane Carvalho,Rafael Cardoso Favaron,Phelipe Oliveira Santos,Amilton Cesar dos Viana,Diego Carvalho Miglino,Maria Angelica |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Fernanda Menezes de Oliveira e Alcantara,Dayane Carvalho,Rafael Cardoso Favaron,Phelipe Oliveira Santos,Amilton Cesar dos Viana,Diego Carvalho Miglino,Maria Angelica |
dc.subject.por.fl_str_mv |
Nervous system embryology animal models histology. |
topic |
Nervous system embryology animal models histology. |
description |
Abstract: This study describes the development of the central nervous system in guinea pigs from 12th day post conception (dpc) until birth. Totally, 41 embryos and fetuses were analyzed macroscopically and by means of light and electron microscopy. The neural tube closure was observed at day 14 and the development of the spinal cord and differentiation of the primitive central nervous system vesicles was on 20th dpc. Histologically, undifferentiated brain tissue was observed as a mass of mesenchymal tissue between 18th and 20th dpc, and at 25th dpc the tissue within the medullary canal had higher density. On day 30 the brain tissue was differentiated on day 30 and the spinal cord filling throughout the spinal canal, period from which it was possible to observe cerebral and cerebellar stratums. At day 45 intumescences were visualized and cerebral hemispheres were divided, with a clear division between white and gray matter in brain and cerebellum. Median sulcus of the dorsal spinal cord and the cauda equina were only evident on day 50. There were no significant structural differences in fetuses of 50 and 60 dpc, and animals at term were all lissencephalic. In conclusion, morphological studies of the nervous system in guinea pig can provide important information for clinical studies in humans, due to its high degree of neurological maturity in relation to its short gestation period, what can provide a good tool for neurological studies. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000800753 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000800753 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2016000800013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.36 n.8 2016 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122236112928768 |