Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018001001949 |
Resumo: | ABSTRACT: In view of the fact that cancer is considered a chronic disease that can interfere with hormonal homeostasis by means of cytokines, we hypothesized that, even at early stages, mammary carcinoma is able to alter the balance of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes. To test this hypothesis, the serum concentrations of basal cortisol, thyroxine (T4), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were evaluated in 20 unspayed bitches that had a histopathological diagnosis of grade 1 mammary carcinoma at clinical stage I according to the World Health Organization (WHO) classification (T1N0M0). The control animals comprised 10 unspayed bitches in perfect health conditions that were matched with those with mammary carcinoma by age. No significant differences regarding the concentrations of basal cortisol, TSH, t4, and fT4 were found between the bitches carrying early stage mammary carcinoma when compared to the control group. This suggests that, even if malignant, early-stage mammary carcinomas do not exhibit the ability to alter the concentrations of hormones produced by the hypothalamic-pituitary-adrenal or hypothalamic-pituitary-thyroid axes. |
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Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinomaSerum concentrationcortisolthyroxinebitchesmammary carcinomadogshormone quantificationmammary cancerendocrine testsclinicsABSTRACT: In view of the fact that cancer is considered a chronic disease that can interfere with hormonal homeostasis by means of cytokines, we hypothesized that, even at early stages, mammary carcinoma is able to alter the balance of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes. To test this hypothesis, the serum concentrations of basal cortisol, thyroxine (T4), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were evaluated in 20 unspayed bitches that had a histopathological diagnosis of grade 1 mammary carcinoma at clinical stage I according to the World Health Organization (WHO) classification (T1N0M0). The control animals comprised 10 unspayed bitches in perfect health conditions that were matched with those with mammary carcinoma by age. No significant differences regarding the concentrations of basal cortisol, TSH, t4, and fT4 were found between the bitches carrying early stage mammary carcinoma when compared to the control group. This suggests that, even if malignant, early-stage mammary carcinomas do not exhibit the ability to alter the concentrations of hormones produced by the hypothalamic-pituitary-adrenal or hypothalamic-pituitary-thyroid axes.Colégio Brasileiro de Patologia Animal - CBPA2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018001001949Pesquisa Veterinária Brasileira v.38 n.10 2018reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/1678-5150-pvb-5264info:eu-repo/semantics/openAccessSalomão,Ricardo L.Crivellenti,Leandro Z.Simões,Ana Paula R.Brito,Marina B.S.Silva,Paloma E.S.Costa,Paula B.Tinucci-Costa,MirelaSantana,Aureo E.Borin-Crivellenti,Sofiaeng2018-11-26T00:00:00Zoai:scielo:S0100-736X2018001001949Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2018-11-26T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
title |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
spellingShingle |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma Salomão,Ricardo L. Serum concentration cortisol thyroxine bitches mammary carcinoma dogs hormone quantification mammary cancer endocrine tests clinics |
title_short |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
title_full |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
title_fullStr |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
title_full_unstemmed |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
title_sort |
Evaluation of serum concentrations of cortisol and thyroxine in bitches with early-stage mammary carcinoma |
author |
Salomão,Ricardo L. |
author_facet |
Salomão,Ricardo L. Crivellenti,Leandro Z. Simões,Ana Paula R. Brito,Marina B.S. Silva,Paloma E.S. Costa,Paula B. Tinucci-Costa,Mirela Santana,Aureo E. Borin-Crivellenti,Sofia |
author_role |
author |
author2 |
Crivellenti,Leandro Z. Simões,Ana Paula R. Brito,Marina B.S. Silva,Paloma E.S. Costa,Paula B. Tinucci-Costa,Mirela Santana,Aureo E. Borin-Crivellenti,Sofia |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Salomão,Ricardo L. Crivellenti,Leandro Z. Simões,Ana Paula R. Brito,Marina B.S. Silva,Paloma E.S. Costa,Paula B. Tinucci-Costa,Mirela Santana,Aureo E. Borin-Crivellenti,Sofia |
dc.subject.por.fl_str_mv |
Serum concentration cortisol thyroxine bitches mammary carcinoma dogs hormone quantification mammary cancer endocrine tests clinics |
topic |
Serum concentration cortisol thyroxine bitches mammary carcinoma dogs hormone quantification mammary cancer endocrine tests clinics |
description |
ABSTRACT: In view of the fact that cancer is considered a chronic disease that can interfere with hormonal homeostasis by means of cytokines, we hypothesized that, even at early stages, mammary carcinoma is able to alter the balance of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes. To test this hypothesis, the serum concentrations of basal cortisol, thyroxine (T4), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) were evaluated in 20 unspayed bitches that had a histopathological diagnosis of grade 1 mammary carcinoma at clinical stage I according to the World Health Organization (WHO) classification (T1N0M0). The control animals comprised 10 unspayed bitches in perfect health conditions that were matched with those with mammary carcinoma by age. No significant differences regarding the concentrations of basal cortisol, TSH, t4, and fT4 were found between the bitches carrying early stage mammary carcinoma when compared to the control group. This suggests that, even if malignant, early-stage mammary carcinomas do not exhibit the ability to alter the concentrations of hormones produced by the hypothalamic-pituitary-adrenal or hypothalamic-pituitary-thyroid axes. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018001001949 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2018001001949 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-5150-pvb-5264 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.38 n.10 2018 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122239009095680 |