Mast cells and angiogenesis in canine mammary tumor

Detalhes bibliográficos
Autor(a) principal: Lavalle,G.E
Data de Publicação: 2010
Outros Autores: Bertagnolli,A.C, Tavares,W.L.F, Ferreira,M.A.N.D, Cassali,G.D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000600008
Resumo: The correlation between microvessel density and mast cells density in canine mammary tumors was studied. Sixty-five samples of canine mammary tumors, being 24 benign and 41 malignant, were analyzed. The routine Toluidine Blue staining method was used to assess the mast cells. To evaluate angiogenesis, the immunohistochemical expression of CD31 was assessed. There was no significant difference in either mast cells (P=0.44) or microvessel density (P=0.77) between malignant and benign tumors. A positive correlation was observed between microvessel density and mast cells (r=0.39; P=0.011) in malignant tumors. These results suggest that mast cells may play a role in canine mammary malignant tumors development, promoting angiogenesis, similar to some tumors described in the human species
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spelling Mast cells and angiogenesis in canine mammary tumorbitchmammary glandmast cellsmicrovessel densityneoplasmsThe correlation between microvessel density and mast cells density in canine mammary tumors was studied. Sixty-five samples of canine mammary tumors, being 24 benign and 41 malignant, were analyzed. The routine Toluidine Blue staining method was used to assess the mast cells. To evaluate angiogenesis, the immunohistochemical expression of CD31 was assessed. There was no significant difference in either mast cells (P=0.44) or microvessel density (P=0.77) between malignant and benign tumors. A positive correlation was observed between microvessel density and mast cells (r=0.39; P=0.011) in malignant tumors. These results suggest that mast cells may play a role in canine mammary malignant tumors development, promoting angiogenesis, similar to some tumors described in the human speciesUniversidade Federal de Minas Gerais, Escola de Veterinária2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000600008Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.6 2010reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352010000600008info:eu-repo/semantics/openAccessLavalle,G.EBertagnolli,A.CTavares,W.L.FFerreira,M.A.N.DCassali,G.Deng2011-02-23T00:00:00Zoai:scielo:S0102-09352010000600008Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2011-02-23T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Mast cells and angiogenesis in canine mammary tumor
title Mast cells and angiogenesis in canine mammary tumor
spellingShingle Mast cells and angiogenesis in canine mammary tumor
Lavalle,G.E
bitch
mammary gland
mast cells
microvessel density
neoplasms
title_short Mast cells and angiogenesis in canine mammary tumor
title_full Mast cells and angiogenesis in canine mammary tumor
title_fullStr Mast cells and angiogenesis in canine mammary tumor
title_full_unstemmed Mast cells and angiogenesis in canine mammary tumor
title_sort Mast cells and angiogenesis in canine mammary tumor
author Lavalle,G.E
author_facet Lavalle,G.E
Bertagnolli,A.C
Tavares,W.L.F
Ferreira,M.A.N.D
Cassali,G.D
author_role author
author2 Bertagnolli,A.C
Tavares,W.L.F
Ferreira,M.A.N.D
Cassali,G.D
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lavalle,G.E
Bertagnolli,A.C
Tavares,W.L.F
Ferreira,M.A.N.D
Cassali,G.D
dc.subject.por.fl_str_mv bitch
mammary gland
mast cells
microvessel density
neoplasms
topic bitch
mammary gland
mast cells
microvessel density
neoplasms
description The correlation between microvessel density and mast cells density in canine mammary tumors was studied. Sixty-five samples of canine mammary tumors, being 24 benign and 41 malignant, were analyzed. The routine Toluidine Blue staining method was used to assess the mast cells. To evaluate angiogenesis, the immunohistochemical expression of CD31 was assessed. There was no significant difference in either mast cells (P=0.44) or microvessel density (P=0.77) between malignant and benign tumors. A positive correlation was observed between microvessel density and mast cells (r=0.39; P=0.011) in malignant tumors. These results suggest that mast cells may play a role in canine mammary malignant tumors development, promoting angiogenesis, similar to some tumors described in the human species
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000600008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000600008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-09352010000600008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.62 n.6 2010
reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Arquivo brasileiro de medicina veterinária e zootecnia (Online)
collection Arquivo brasileiro de medicina veterinária e zootecnia (Online)
repository.name.fl_str_mv Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br
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