The anthelmintic activity of mebendazole in horses
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Pesquisa Agropecuária Brasileira (Online) |
Texto Completo: | https://seer.sct.embrapa.br/index.php/pab/article/view/17407 |
Resumo: | An aqueous solution and granular formulation of mebendazole were tested for their anthelmintic activity in horses. Single doses of 1, 2 and 4 g removed 100% of Oxyuris equi, Strongylur spp. and Probstrnayria vivipara; 77.8-97.7% of the helminths of the genera Trichonema and Triodontophorus were removed with 1 g, 95.1-98.6% with 2 g and 97.9-99.4% with 4 g. The results of fecal examination and larval cultures demonstrated that 24 hours after the administration of the medication the viability of the eggs of the helminths was extremely low and after 48 hours no eggs were found. The safety margin of mebendazole is ample, a dose of 30 g (166 mg/kg) did not give symptoms of intoxication. The granular formulation for mixing in the ration was palatable and well accepted by the animals. |
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The anthelmintic activity of mebendazole in horsesAção anti-helmíntica do mebendazole em equinosAn aqueous solution and granular formulation of mebendazole were tested for their anthelmintic activity in horses. Single doses of 1, 2 and 4 g removed 100% of Oxyuris equi, Strongylur spp. and Probstrnayria vivipara; 77.8-97.7% of the helminths of the genera Trichonema and Triodontophorus were removed with 1 g, 95.1-98.6% with 2 g and 97.9-99.4% with 4 g. The results of fecal examination and larval cultures demonstrated that 24 hours after the administration of the medication the viability of the eggs of the helminths was extremely low and after 48 hours no eggs were found. The safety margin of mebendazole is ample, a dose of 30 g (166 mg/kg) did not give symptoms of intoxication. The granular formulation for mixing in the ration was palatable and well accepted by the animals.A atividade anti-helmíntica do mebendazole5 em equinos, administrado em solução aquosa e em granulado, foi avaliada por teste crítico. Doses únicas de 1, 2 e 4 g removeram 100% dos Oxyuris equi e dos grandes estrôngilos; os pequenos estrêngilos foram removidos em 77,8-97,7% com 1 g, 95,1-98,6% com 2 g e 97,9-99,4% com 4 g. Os resultados dos exames de fezes e coproculturas demonstraram que 24 horas após a administração do medicamento a viabilidade dos ovos dos helmintos é inexpressiva e, em 48 horas, todos os exames foram negativos. A margem de segurança do mebendazole é ampla; dose de 30 g (166 mg/kg) não apresentou sintomas de intoxicação. A apresentação granulada para misturar à ração é palatável, sendo bem aceita pelos animais.Pesquisa Agropecuaria BrasileiraPesquisa Agropecuária BrasileiraSantiago, M. A.M.Costa, U. C. daBenevenga, S.Silva, Valter P. da2014-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.sct.embrapa.br/index.php/pab/article/view/17407Pesquisa Agropecuaria Brasileira; v.8, n.6, 1973: Série Veterinária; 121-123Pesquisa Agropecuária Brasileira; v.8, n.6, 1973: Série Veterinária; 121-1231678-39210100-104xreponame:Pesquisa Agropecuária Brasileira (Online)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPAporhttps://seer.sct.embrapa.br/index.php/pab/article/view/17407/11671info:eu-repo/semantics/openAccess2014-04-15T18:46:32Zoai:ojs.seer.sct.embrapa.br:article/17407Revistahttp://seer.sct.embrapa.br/index.php/pabPRIhttps://old.scielo.br/oai/scielo-oai.phppab@sct.embrapa.br || sct.pab@embrapa.br1678-39210100-204Xopendoar:2014-04-15T18:46:32Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
The anthelmintic activity of mebendazole in horses Ação anti-helmíntica do mebendazole em equinos |
title |
The anthelmintic activity of mebendazole in horses |
spellingShingle |
The anthelmintic activity of mebendazole in horses Santiago, M. A.M. |
title_short |
The anthelmintic activity of mebendazole in horses |
title_full |
The anthelmintic activity of mebendazole in horses |
title_fullStr |
The anthelmintic activity of mebendazole in horses |
title_full_unstemmed |
The anthelmintic activity of mebendazole in horses |
title_sort |
The anthelmintic activity of mebendazole in horses |
author |
Santiago, M. A.M. |
author_facet |
Santiago, M. A.M. Costa, U. C. da Benevenga, S. Silva, Valter P. da |
author_role |
author |
author2 |
Costa, U. C. da Benevenga, S. Silva, Valter P. da |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Santiago, M. A.M. Costa, U. C. da Benevenga, S. Silva, Valter P. da |
dc.subject.none.fl_str_mv |
|
description |
An aqueous solution and granular formulation of mebendazole were tested for their anthelmintic activity in horses. Single doses of 1, 2 and 4 g removed 100% of Oxyuris equi, Strongylur spp. and Probstrnayria vivipara; 77.8-97.7% of the helminths of the genera Trichonema and Triodontophorus were removed with 1 g, 95.1-98.6% with 2 g and 97.9-99.4% with 4 g. The results of fecal examination and larval cultures demonstrated that 24 hours after the administration of the medication the viability of the eggs of the helminths was extremely low and after 48 hours no eggs were found. The safety margin of mebendazole is ample, a dose of 30 g (166 mg/kg) did not give symptoms of intoxication. The granular formulation for mixing in the ration was palatable and well accepted by the animals. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-15 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.sct.embrapa.br/index.php/pab/article/view/17407 |
url |
https://seer.sct.embrapa.br/index.php/pab/article/view/17407 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.sct.embrapa.br/index.php/pab/article/view/17407/11671 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira Pesquisa Agropecuária Brasileira |
publisher.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira Pesquisa Agropecuária Brasileira |
dc.source.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira; v.8, n.6, 1973: Série Veterinária; 121-123 Pesquisa Agropecuária Brasileira; v.8, n.6, 1973: Série Veterinária; 121-123 1678-3921 0100-104x reponame:Pesquisa Agropecuária Brasileira (Online) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Agropecuária Brasileira (Online) |
collection |
Pesquisa Agropecuária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
pab@sct.embrapa.br || sct.pab@embrapa.br |
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1793416693059420160 |