Neoangiogenesis of skin fl aps in rats treated with copaiba oil
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Pesquisa Agropecuária Brasileira (Online) |
Texto Completo: | https://seer.sct.embrapa.br/index.php/pab/article/view/1716 |
Resumo: | The aim of this work was to evaluate morphometric aspects of subdermic skin flap neoangiogenesis in rats treated with a 10% copaiba (Copaifera langsdorffii) oil ointment. The experiment design was a completely randomized, with three pharmacological resources. Ten replicates were used for each resource, and each animal was considered one experimental unit. Thirty Wistar rats were submitted to subdermic dorsal skin flap elevation and distributed into three groups: absolute control group, in which the animals did not receive any treatment; control group, in which the animals received topical treatment only with vehicle (glycerin and petroleum jelly), and treated group, in which the animals were treated daily with a 10% copaiba oil ointment. The rats were treated and observed for eight days after surgery. On the eighth day, the skin flap underwent a macroscopic analysis and fragments were collected from its cranial, medial and caudal portions for histopathological analysis. The morphometric analysis showed significant difference for proliferation of newly formed vessels in the middle and caudal portions of the skin flap in the treated group. Copaiba oil showed efficiency in the increase of neoangiogenesis of subdermic skin flaps in rats. |
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Neoangiogenesis of skin fl aps in rats treated with copaiba oilNeoangiogênese de retalhos cutâneos em ratos tratados com óleo de copaíbaCopaifera langsdorffii; ischaemia; neovascularizationCopaifera langsdorffii; isquemia; neovascularizaçãoThe aim of this work was to evaluate morphometric aspects of subdermic skin flap neoangiogenesis in rats treated with a 10% copaiba (Copaifera langsdorffii) oil ointment. The experiment design was a completely randomized, with three pharmacological resources. Ten replicates were used for each resource, and each animal was considered one experimental unit. Thirty Wistar rats were submitted to subdermic dorsal skin flap elevation and distributed into three groups: absolute control group, in which the animals did not receive any treatment; control group, in which the animals received topical treatment only with vehicle (glycerin and petroleum jelly), and treated group, in which the animals were treated daily with a 10% copaiba oil ointment. The rats were treated and observed for eight days after surgery. On the eighth day, the skin flap underwent a macroscopic analysis and fragments were collected from its cranial, medial and caudal portions for histopathological analysis. The morphometric analysis showed significant difference for proliferation of newly formed vessels in the middle and caudal portions of the skin flap in the treated group. Copaiba oil showed efficiency in the increase of neoangiogenesis of subdermic skin flaps in rats.O objetivo deste trabalho foi avaliar morfometricamente a neoangiogênese de retalhos cutâneos subdérmicos em ratos tratados com óleo de copaíba (Copaifera langsdorffii) em pomada a 10%. O delineamento experimental foi inteiramente casualizado, composto por três recursos farmacológicos. Foram utilizadas dez repetições para cada recurso, e cada animal foi considerado uma unidade experimental. Trinta ratos Wistar foram submetidos à elevação do retalho cutâneo dorsal subdérmico e distribuídos em três grupos: grupo controle absoluto, no qual os animais não receberam nenhum tratamento; grupo controle, no qual os animais receberam tratamento tópico diário com pomada com apenas veículo (glicerina e vaselina); e grupo tratado, no qual os animais foram tratados diariamente com óleo de copaíba em pomada a 10%. Os ratos foram tratados e observados por oito dias após o ato operatório. No oitavo dia de pós-operatório, realizou-se a análise macroscópica do retalho e foram coletados fragmentos das porções cranial, média e caudal do retalho cutâneo para análise histopatológica. A análise morfométrica mostrou diferença significativa para o número de novos vasos sanguíneos nas partes média e caudal do retalho cutâneo no grupo tratado. O óleo de copaíba mostra-se eficiente no aumento da neoangiogênese em retalhos cutâneos subdérmicos de ratos.Pesquisa Agropecuaria BrasileiraPesquisa Agropecuária BrasileiraCAPESCNPqEstevão, Lígia Reis de MouraMedeiros, Juliana Pinto deScognamillo-Szabó, Marcia Valéria RizzoBaratella-Evêncio, LirianeGuimarães, Ednaldo CarvalhoCâmara, Claudio Augusto Gomes daEvêncio-Neto, Joaquim2010-11-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.sct.embrapa.br/index.php/pab/article/view/1716Pesquisa Agropecuaria Brasileira; v.44, n.4, abr. 2009; 406-412Pesquisa Agropecuária Brasileira; v.44, n.4, abr. 2009; 406-4121678-39210100-104xreponame:Pesquisa Agropecuária Brasileira (Online)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPAporhttps://seer.sct.embrapa.br/index.php/pab/article/view/1716/5694https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/1716/1147https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/1716/1844https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/1716/1925info:eu-repo/semantics/openAccess2012-06-17T11:48:31Zoai:ojs.seer.sct.embrapa.br:article/1716Revistahttp://seer.sct.embrapa.br/index.php/pabPRIhttps://old.scielo.br/oai/scielo-oai.phppab@sct.embrapa.br || sct.pab@embrapa.br1678-39210100-204Xopendoar:2012-06-17T11:48:31Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil Neoangiogênese de retalhos cutâneos em ratos tratados com óleo de copaíba |
title |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil |
spellingShingle |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil Estevão, Lígia Reis de Moura Copaifera langsdorffii; ischaemia; neovascularization Copaifera langsdorffii; isquemia; neovascularização |
title_short |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil |
title_full |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil |
title_fullStr |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil |
title_full_unstemmed |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil |
title_sort |
Neoangiogenesis of skin fl aps in rats treated with copaiba oil |
author |
Estevão, Lígia Reis de Moura |
author_facet |
Estevão, Lígia Reis de Moura Medeiros, Juliana Pinto de Scognamillo-Szabó, Marcia Valéria Rizzo Baratella-Evêncio, Liriane Guimarães, Ednaldo Carvalho Câmara, Claudio Augusto Gomes da Evêncio-Neto, Joaquim |
author_role |
author |
author2 |
Medeiros, Juliana Pinto de Scognamillo-Szabó, Marcia Valéria Rizzo Baratella-Evêncio, Liriane Guimarães, Ednaldo Carvalho Câmara, Claudio Augusto Gomes da Evêncio-Neto, Joaquim |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
CAPES CNPq |
dc.contributor.author.fl_str_mv |
Estevão, Lígia Reis de Moura Medeiros, Juliana Pinto de Scognamillo-Szabó, Marcia Valéria Rizzo Baratella-Evêncio, Liriane Guimarães, Ednaldo Carvalho Câmara, Claudio Augusto Gomes da Evêncio-Neto, Joaquim |
dc.subject.por.fl_str_mv |
Copaifera langsdorffii; ischaemia; neovascularization Copaifera langsdorffii; isquemia; neovascularização |
topic |
Copaifera langsdorffii; ischaemia; neovascularization Copaifera langsdorffii; isquemia; neovascularização |
description |
The aim of this work was to evaluate morphometric aspects of subdermic skin flap neoangiogenesis in rats treated with a 10% copaiba (Copaifera langsdorffii) oil ointment. The experiment design was a completely randomized, with three pharmacological resources. Ten replicates were used for each resource, and each animal was considered one experimental unit. Thirty Wistar rats were submitted to subdermic dorsal skin flap elevation and distributed into three groups: absolute control group, in which the animals did not receive any treatment; control group, in which the animals received topical treatment only with vehicle (glycerin and petroleum jelly), and treated group, in which the animals were treated daily with a 10% copaiba oil ointment. The rats were treated and observed for eight days after surgery. On the eighth day, the skin flap underwent a macroscopic analysis and fragments were collected from its cranial, medial and caudal portions for histopathological analysis. The morphometric analysis showed significant difference for proliferation of newly formed vessels in the middle and caudal portions of the skin flap in the treated group. Copaiba oil showed efficiency in the increase of neoangiogenesis of subdermic skin flaps in rats. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-11-11 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.sct.embrapa.br/index.php/pab/article/view/1716 |
url |
https://seer.sct.embrapa.br/index.php/pab/article/view/1716 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.sct.embrapa.br/index.php/pab/article/view/1716/5694 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/1716/1147 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/1716/1844 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/1716/1925 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira Pesquisa Agropecuária Brasileira |
publisher.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira Pesquisa Agropecuária Brasileira |
dc.source.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira; v.44, n.4, abr. 2009; 406-412 Pesquisa Agropecuária Brasileira; v.44, n.4, abr. 2009; 406-412 1678-3921 0100-104x reponame:Pesquisa Agropecuária Brasileira (Online) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Agropecuária Brasileira (Online) |
collection |
Pesquisa Agropecuária Brasileira (Online) |
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Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
pab@sct.embrapa.br || sct.pab@embrapa.br |
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1793416680056029184 |