Estimation of recombination frequency in genetic mapping of full-sib families
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Pesquisa Agropecuária Brasileira (Online) |
Texto Completo: | https://seer.sct.embrapa.br/index.php/pab/article/view/24 |
Resumo: | The objective of this work was to obtain the estimates of recombination frequency, through simulation, for different situations in genetic mapping involving full sibling families. A genome with three linkage groups simulated, each one with 11 molecular marks which were multi-allelic, codominants, with saturation of 10 cM. Starting from this genome, two situations were simulated: one with informative genitors, and other with genitors formed randomly. Once all the recombination frequencies were estimated, it was found out that in completely informative loci, the recombination frequency can be calculated among equal pairs of loci starting from the gametic frequency of each genitor, or starting from the genotipic frequency of the progeny. For partially informative loci, the recombination frequency starting from the united genotipic frequency is more appropriate. |
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Estimation of recombination frequency in genetic mapping of full-sib familiesEstimativa de freqüência de recombinação no mapeamento genético de famílias de irmãos completosgenomics; exogamic populations; maxim likelihoodgenômica; máxima verossimilhança; populações exogâmicasThe objective of this work was to obtain the estimates of recombination frequency, through simulation, for different situations in genetic mapping involving full sibling families. A genome with three linkage groups simulated, each one with 11 molecular marks which were multi-allelic, codominants, with saturation of 10 cM. Starting from this genome, two situations were simulated: one with informative genitors, and other with genitors formed randomly. Once all the recombination frequencies were estimated, it was found out that in completely informative loci, the recombination frequency can be calculated among equal pairs of loci starting from the gametic frequency of each genitor, or starting from the genotipic frequency of the progeny. For partially informative loci, the recombination frequency starting from the united genotipic frequency is more appropriate.O objetivo deste trabalho foi obter as estimativas de freqüência de recombinação, por meio de simulação, para diferentes situações do mapeamento genético de famílias de irmãos completos. Foi simulado um genoma constituído de três grupos de ligação, em que cada um apresentava 11 marcas moleculares multialélicas, codominantes, distribuídas a cada 10 cM. A partir desse genoma, foram simulados dois cenários: um com genitores completamente informativos e outro com genitores formados aleatoriamente. Após a obtenção de todas as estimativas das freqüências de recombinação, concluiu-se que, para locos completamente informativos, pode-se calcular a freqüência de recombinação entre pares de locos, a partir da freqüência gamética de cada genitor ou a partir da freqüência genotípica da progênie. Para locos parcialmente informativos, a obtenção da freqüência de recombinação a partir da freqüência genotípica conjunta é mais apropriada.Pesquisa Agropecuaria BrasileiraPesquisa Agropecuária BrasileiraCNPqBhering, Leonardo LopesCruz, Cosme DamiãoGod, Pedro Ivo Vieira Good2008-09-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.sct.embrapa.br/index.php/pab/article/view/24Pesquisa Agropecuaria Brasileira; v.43, n.3, mar. 2008; 363-369Pesquisa Agropecuária Brasileira; v.43, n.3, mar. 2008; 363-3691678-39210100-104xreponame:Pesquisa Agropecuária Brasileira (Online)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPAporhttps://seer.sct.embrapa.br/index.php/pab/article/view/24/158https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/11https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/12https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/13https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/14info:eu-repo/semantics/openAccess2014-04-30T18:21:02Zoai:ojs.seer.sct.embrapa.br:article/24Revistahttp://seer.sct.embrapa.br/index.php/pabPRIhttps://old.scielo.br/oai/scielo-oai.phppab@sct.embrapa.br || sct.pab@embrapa.br1678-39210100-204Xopendoar:2014-04-30T18:21:02Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Estimation of recombination frequency in genetic mapping of full-sib families Estimativa de freqüência de recombinação no mapeamento genético de famílias de irmãos completos |
title |
Estimation of recombination frequency in genetic mapping of full-sib families |
spellingShingle |
Estimation of recombination frequency in genetic mapping of full-sib families Bhering, Leonardo Lopes genomics; exogamic populations; maxim likelihood genômica; máxima verossimilhança; populações exogâmicas |
title_short |
Estimation of recombination frequency in genetic mapping of full-sib families |
title_full |
Estimation of recombination frequency in genetic mapping of full-sib families |
title_fullStr |
Estimation of recombination frequency in genetic mapping of full-sib families |
title_full_unstemmed |
Estimation of recombination frequency in genetic mapping of full-sib families |
title_sort |
Estimation of recombination frequency in genetic mapping of full-sib families |
author |
Bhering, Leonardo Lopes |
author_facet |
Bhering, Leonardo Lopes Cruz, Cosme Damião God, Pedro Ivo Vieira Good |
author_role |
author |
author2 |
Cruz, Cosme Damião God, Pedro Ivo Vieira Good |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
CNPq |
dc.contributor.author.fl_str_mv |
Bhering, Leonardo Lopes Cruz, Cosme Damião God, Pedro Ivo Vieira Good |
dc.subject.por.fl_str_mv |
genomics; exogamic populations; maxim likelihood genômica; máxima verossimilhança; populações exogâmicas |
topic |
genomics; exogamic populations; maxim likelihood genômica; máxima verossimilhança; populações exogâmicas |
description |
The objective of this work was to obtain the estimates of recombination frequency, through simulation, for different situations in genetic mapping involving full sibling families. A genome with three linkage groups simulated, each one with 11 molecular marks which were multi-allelic, codominants, with saturation of 10 cM. Starting from this genome, two situations were simulated: one with informative genitors, and other with genitors formed randomly. Once all the recombination frequencies were estimated, it was found out that in completely informative loci, the recombination frequency can be calculated among equal pairs of loci starting from the gametic frequency of each genitor, or starting from the genotipic frequency of the progeny. For partially informative loci, the recombination frequency starting from the united genotipic frequency is more appropriate. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-09-03 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.sct.embrapa.br/index.php/pab/article/view/24 |
url |
https://seer.sct.embrapa.br/index.php/pab/article/view/24 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.sct.embrapa.br/index.php/pab/article/view/24/158 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/11 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/12 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/13 https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/14 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira Pesquisa Agropecuária Brasileira |
publisher.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira Pesquisa Agropecuária Brasileira |
dc.source.none.fl_str_mv |
Pesquisa Agropecuaria Brasileira; v.43, n.3, mar. 2008; 363-369 Pesquisa Agropecuária Brasileira; v.43, n.3, mar. 2008; 363-369 1678-3921 0100-104x reponame:Pesquisa Agropecuária Brasileira (Online) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Agropecuária Brasileira (Online) |
collection |
Pesquisa Agropecuária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
pab@sct.embrapa.br || sct.pab@embrapa.br |
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1793416656054124544 |