Estimation of recombination frequency in genetic mapping of full-sib families

Detalhes bibliográficos
Autor(a) principal: Bhering, Leonardo Lopes
Data de Publicação: 2008
Outros Autores: Cruz, Cosme Damião, God, Pedro Ivo Vieira Good
Tipo de documento: Artigo
Idioma: por
Título da fonte: Pesquisa Agropecuária Brasileira (Online)
Texto Completo: https://seer.sct.embrapa.br/index.php/pab/article/view/24
Resumo: The objective of this work was to obtain the estimates of recombination frequency, through simulation, for different situations in genetic mapping involving full sibling families. A genome with three linkage groups simulated, each one with 11 molecular marks which were multi-allelic, codominants, with saturation of 10 cM. Starting from this genome, two situations were simulated: one with informative genitors, and other with genitors formed randomly. Once all the recombination frequencies were estimated, it was found out that in completely informative loci, the recombination frequency can be calculated among equal pairs of loci starting from the gametic frequency of each genitor, or starting from the genotipic frequency of the progeny. For partially informative loci, the recombination frequency starting from the united genotipic frequency is more appropriate.
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spelling Estimation of recombination frequency in genetic mapping of full-sib familiesEstimativa de freqüência de recombinação no mapeamento genético de famílias de irmãos completosgenomics; exogamic populations; maxim likelihoodgenômica; máxima verossimilhança; populações exogâmicasThe objective of this work was to obtain the estimates of recombination frequency, through simulation, for different situations in genetic mapping involving full sibling families. A genome with three linkage groups simulated, each one with 11 molecular marks which were multi-allelic, codominants, with saturation of 10 cM. Starting from this genome, two situations were simulated: one with informative genitors, and other with genitors formed randomly. Once all the recombination frequencies were estimated, it was found out that in completely informative loci, the recombination frequency can be calculated among equal pairs of loci starting from the gametic frequency of each genitor, or starting from the genotipic frequency of the progeny. For partially informative loci, the recombination frequency starting from the united genotipic frequency is more appropriate.O objetivo deste trabalho foi obter as estimativas de freqüência de recombinação, por meio de simulação, para diferentes situações do mapeamento genético de famílias de irmãos completos. Foi simulado um genoma constituído de três grupos de ligação, em que cada um apresentava 11 marcas moleculares multialélicas, codominantes, distribuídas a cada 10 cM. A partir desse genoma, foram simulados dois cenários: um com genitores completamente informativos e outro com genitores formados aleatoriamente. Após a obtenção de todas as estimativas das freqüências de recombinação, concluiu-se que, para locos completamente informativos, pode-se calcular a freqüência de recombinação entre pares de locos, a partir da freqüência gamética de cada genitor ou a partir da freqüência genotípica da progênie. Para locos parcialmente informativos, a obtenção da freqüência de recombinação a partir da freqüência genotípica conjunta é mais apropriada.Pesquisa Agropecuaria BrasileiraPesquisa Agropecuária BrasileiraCNPqBhering, Leonardo LopesCruz, Cosme DamiãoGod, Pedro Ivo Vieira Good2008-09-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.sct.embrapa.br/index.php/pab/article/view/24Pesquisa Agropecuaria Brasileira; v.43, n.3, mar. 2008; 363-369Pesquisa Agropecuária Brasileira; v.43, n.3, mar. 2008; 363-3691678-39210100-104xreponame:Pesquisa Agropecuária Brasileira (Online)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPAporhttps://seer.sct.embrapa.br/index.php/pab/article/view/24/158https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/11https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/12https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/13https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/14info:eu-repo/semantics/openAccess2014-04-30T18:21:02Zoai:ojs.seer.sct.embrapa.br:article/24Revistahttp://seer.sct.embrapa.br/index.php/pabPRIhttps://old.scielo.br/oai/scielo-oai.phppab@sct.embrapa.br || sct.pab@embrapa.br1678-39210100-204Xopendoar:2014-04-30T18:21:02Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Estimation of recombination frequency in genetic mapping of full-sib families
Estimativa de freqüência de recombinação no mapeamento genético de famílias de irmãos completos
title Estimation of recombination frequency in genetic mapping of full-sib families
spellingShingle Estimation of recombination frequency in genetic mapping of full-sib families
Bhering, Leonardo Lopes
genomics; exogamic populations; maxim likelihood
genômica; máxima verossimilhança; populações exogâmicas
title_short Estimation of recombination frequency in genetic mapping of full-sib families
title_full Estimation of recombination frequency in genetic mapping of full-sib families
title_fullStr Estimation of recombination frequency in genetic mapping of full-sib families
title_full_unstemmed Estimation of recombination frequency in genetic mapping of full-sib families
title_sort Estimation of recombination frequency in genetic mapping of full-sib families
author Bhering, Leonardo Lopes
author_facet Bhering, Leonardo Lopes
Cruz, Cosme Damião
God, Pedro Ivo Vieira Good
author_role author
author2 Cruz, Cosme Damião
God, Pedro Ivo Vieira Good
author2_role author
author
dc.contributor.none.fl_str_mv
CNPq
dc.contributor.author.fl_str_mv Bhering, Leonardo Lopes
Cruz, Cosme Damião
God, Pedro Ivo Vieira Good
dc.subject.por.fl_str_mv genomics; exogamic populations; maxim likelihood
genômica; máxima verossimilhança; populações exogâmicas
topic genomics; exogamic populations; maxim likelihood
genômica; máxima verossimilhança; populações exogâmicas
description The objective of this work was to obtain the estimates of recombination frequency, through simulation, for different situations in genetic mapping involving full sibling families. A genome with three linkage groups simulated, each one with 11 molecular marks which were multi-allelic, codominants, with saturation of 10 cM. Starting from this genome, two situations were simulated: one with informative genitors, and other with genitors formed randomly. Once all the recombination frequencies were estimated, it was found out that in completely informative loci, the recombination frequency can be calculated among equal pairs of loci starting from the gametic frequency of each genitor, or starting from the genotipic frequency of the progeny. For partially informative loci, the recombination frequency starting from the united genotipic frequency is more appropriate.
publishDate 2008
dc.date.none.fl_str_mv 2008-09-03
dc.type.none.fl_str_mv
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.sct.embrapa.br/index.php/pab/article/view/24
url https://seer.sct.embrapa.br/index.php/pab/article/view/24
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.sct.embrapa.br/index.php/pab/article/view/24/158
https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/11
https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/12
https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/13
https://seer.sct.embrapa.br/index.php/pab/article/downloadSuppFile/24/14
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pesquisa Agropecuaria Brasileira
Pesquisa Agropecuária Brasileira
publisher.none.fl_str_mv Pesquisa Agropecuaria Brasileira
Pesquisa Agropecuária Brasileira
dc.source.none.fl_str_mv Pesquisa Agropecuaria Brasileira; v.43, n.3, mar. 2008; 363-369
Pesquisa Agropecuária Brasileira; v.43, n.3, mar. 2008; 363-369
1678-3921
0100-104x
reponame:Pesquisa Agropecuária Brasileira (Online)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Pesquisa Agropecuária Brasileira (Online)
collection Pesquisa Agropecuária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv pab@sct.embrapa.br || sct.pab@embrapa.br
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