Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep

Detalhes bibliográficos
Autor(a) principal: NICIURA, S. C. M.
Data de Publicação: 2024
Outros Autores: CARDOSO, T. F., IBELLI, A. M. G., OKINO, C. H., ANDRADE, B. G., BENAVIDES, M. V., CHAGAS, A. C. de S., ESTEVES, S. N., MINHO, A. P., REGITANO, L. C. de A., GONDRO, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1162588
Resumo: The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance. This understanding will help refine management practices and advance the development of new therapeutics for long-term helminth control.
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spelling Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheepGWASRNA seq16S rDNA sequencingEQTLParasite resistanceBarber’s pole wormThe integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance. This understanding will help refine management practices and advance the development of new therapeutics for long-term helminth control.SIMONE CRISTINA MEO NICIURA, CPPSE; TAINÃ FIGUEIREDO CARDOSO; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; CINTIA HIROMI OKINO, CPPSE; BRUNO GABRIEL ANDRADE, Munster Technological University, Cork, Ireland; MAGDA VIEIRA BENAVIDES, CPPSUL; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ALESSANDRO PELEGRINE MINHO, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; CEDRIC GONDRO, Michigan State University, East Lansing, MI, USA.NICIURA, S. C. M.CARDOSO, T. F.IBELLI, A. M. G.OKINO, C. H.ANDRADE, B. G.BENAVIDES, M. V.CHAGAS, A. C. de S.ESTEVES, S. N.MINHO, A. P.REGITANO, L. C. de A.GONDRO, C.2024-03-05T17:32:27Z2024-03-05T17:32:27Z2024-03-052024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParasites & Vectors, v. 17, n. 102, 2024.http://www.alice.cnptia.embrapa.br/alice/handle/doc/116258810.1186/s13071-024-06205-9enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2024-03-05T17:32:27Zoai:www.alice.cnptia.embrapa.br:doc/1162588Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542024-03-05T17:32:27falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542024-03-05T17:32:27Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
title Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
spellingShingle Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
NICIURA, S. C. M.
GWAS
RNA seq
16S rDNA sequencing
EQTL
Parasite resistance
Barber’s pole worm
title_short Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
title_full Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
title_fullStr Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
title_full_unstemmed Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
title_sort Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep
author NICIURA, S. C. M.
author_facet NICIURA, S. C. M.
CARDOSO, T. F.
IBELLI, A. M. G.
OKINO, C. H.
ANDRADE, B. G.
BENAVIDES, M. V.
CHAGAS, A. C. de S.
ESTEVES, S. N.
MINHO, A. P.
REGITANO, L. C. de A.
GONDRO, C.
author_role author
author2 CARDOSO, T. F.
IBELLI, A. M. G.
OKINO, C. H.
ANDRADE, B. G.
BENAVIDES, M. V.
CHAGAS, A. C. de S.
ESTEVES, S. N.
MINHO, A. P.
REGITANO, L. C. de A.
GONDRO, C.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv SIMONE CRISTINA MEO NICIURA, CPPSE; TAINÃ FIGUEIREDO CARDOSO; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; CINTIA HIROMI OKINO, CPPSE; BRUNO GABRIEL ANDRADE, Munster Technological University, Cork, Ireland; MAGDA VIEIRA BENAVIDES, CPPSUL; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ALESSANDRO PELEGRINE MINHO, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; CEDRIC GONDRO, Michigan State University, East Lansing, MI, USA.
dc.contributor.author.fl_str_mv NICIURA, S. C. M.
CARDOSO, T. F.
IBELLI, A. M. G.
OKINO, C. H.
ANDRADE, B. G.
BENAVIDES, M. V.
CHAGAS, A. C. de S.
ESTEVES, S. N.
MINHO, A. P.
REGITANO, L. C. de A.
GONDRO, C.
dc.subject.por.fl_str_mv GWAS
RNA seq
16S rDNA sequencing
EQTL
Parasite resistance
Barber’s pole worm
topic GWAS
RNA seq
16S rDNA sequencing
EQTL
Parasite resistance
Barber’s pole worm
description The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance. This understanding will help refine management practices and advance the development of new therapeutics for long-term helminth control.
publishDate 2024
dc.date.none.fl_str_mv 2024-03-05T17:32:27Z
2024-03-05T17:32:27Z
2024-03-05
2024
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Parasites & Vectors, v. 17, n. 102, 2024.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1162588
10.1186/s13071-024-06205-9
identifier_str_mv Parasites & Vectors, v. 17, n. 102, 2024.
10.1186/s13071-024-06205-9
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1162588
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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