In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/681123 |
Resumo: | In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived. |
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In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.Isolação in vitroPlantaPlasmodium falciparumAmazoniamalariaIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.Valter F. de Andrade-Neto, Inpa; Adrian M. Pohlit, Inpa; Ana Cristina S. Pinto, Inpa/Ufam; Ellen Cristina C. Silva, Inpa/Ufam; Karla L. Nogueira, Inpa/CEFET-AM; Márcia R.S. Melo, Inpa/FMTM; Marycleuma C. Henrique, Inpa/Ufam; Rodrigo C.N. Amorim, Inpa/Ufam; Luis Francisco R. Silva, FMTM; Mônica R.F. Costa, FMTM; Rita C.S. Nunomura, Inpa; Sergio M. Nunomura, Inpa; Wilson D. Alecrim, FMTM; Maria das Graças C. Alecrim, Inpa/UniNilton Lins; Francisco Célio Maia Chaves, CPAA; Pedro Paulo R. Vieira, UEA.ANDRADE-NETO, V. F. dePOHLIT, A. M.PINTO, A. C. S.SILVA, E. C. C.NOGUEIRA, K. L.MELO, M. R. S.HENRIQUE, M. C.AMORIM, R. C. N.SILVA, L. F. R.COSTA, M. R. F.NUNOMURA, R. C. S.NUNOMURA, S. M.ALECRIM, W. D.ALECRIM, M. das G. C.CHAVES, F. C. M.VIEIRA, P. P. R.2015-01-07T08:23:46Z2015-01-07T08:23:46Z2007-09-1820072015-01-07T08:23:46Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMemórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007.http://www.alice.cnptia.embrapa.br/alice/handle/doc/681123enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-16T01:40:30Zoai:www.alice.cnptia.embrapa.br:doc/681123Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-16T01:40:30Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
title |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
spellingShingle |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. ANDRADE-NETO, V. F. de Isolação in vitro Planta Plasmodium falciparum Amazonia malaria |
title_short |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
title_full |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
title_fullStr |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
title_full_unstemmed |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
title_sort |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
author |
ANDRADE-NETO, V. F. de |
author_facet |
ANDRADE-NETO, V. F. de POHLIT, A. M. PINTO, A. C. S. SILVA, E. C. C. NOGUEIRA, K. L. MELO, M. R. S. HENRIQUE, M. C. AMORIM, R. C. N. SILVA, L. F. R. COSTA, M. R. F. NUNOMURA, R. C. S. NUNOMURA, S. M. ALECRIM, W. D. ALECRIM, M. das G. C. CHAVES, F. C. M. VIEIRA, P. P. R. |
author_role |
author |
author2 |
POHLIT, A. M. PINTO, A. C. S. SILVA, E. C. C. NOGUEIRA, K. L. MELO, M. R. S. HENRIQUE, M. C. AMORIM, R. C. N. SILVA, L. F. R. COSTA, M. R. F. NUNOMURA, R. C. S. NUNOMURA, S. M. ALECRIM, W. D. ALECRIM, M. das G. C. CHAVES, F. C. M. VIEIRA, P. P. R. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Valter F. de Andrade-Neto, Inpa; Adrian M. Pohlit, Inpa; Ana Cristina S. Pinto, Inpa/Ufam; Ellen Cristina C. Silva, Inpa/Ufam; Karla L. Nogueira, Inpa/CEFET-AM; Márcia R.S. Melo, Inpa/FMTM; Marycleuma C. Henrique, Inpa/Ufam; Rodrigo C.N. Amorim, Inpa/Ufam; Luis Francisco R. Silva, FMTM; Mônica R.F. Costa, FMTM; Rita C.S. Nunomura, Inpa; Sergio M. Nunomura, Inpa; Wilson D. Alecrim, FMTM; Maria das Graças C. Alecrim, Inpa/UniNilton Lins; Francisco Célio Maia Chaves, CPAA; Pedro Paulo R. Vieira, UEA. |
dc.contributor.author.fl_str_mv |
ANDRADE-NETO, V. F. de POHLIT, A. M. PINTO, A. C. S. SILVA, E. C. C. NOGUEIRA, K. L. MELO, M. R. S. HENRIQUE, M. C. AMORIM, R. C. N. SILVA, L. F. R. COSTA, M. R. F. NUNOMURA, R. C. S. NUNOMURA, S. M. ALECRIM, W. D. ALECRIM, M. das G. C. CHAVES, F. C. M. VIEIRA, P. P. R. |
dc.subject.por.fl_str_mv |
Isolação in vitro Planta Plasmodium falciparum Amazonia malaria |
topic |
Isolação in vitro Planta Plasmodium falciparum Amazonia malaria |
description |
In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-09-18 2007 2015-01-07T08:23:46Z 2015-01-07T08:23:46Z 2015-01-07T08:23:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007. http://www.alice.cnptia.embrapa.br/alice/handle/doc/681123 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/681123 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
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Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
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EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1817695359576571904 |