Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers.
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1154455 |
Resumo: | Iron is essential to several biological processes, such as oxygen transport and lipid metabolism. In this study, the RNA sequencing technology (RNAseq) was adopted to identify differentially expressed genes (DE) and metabolic pathways, as well as its relationship with meat quality parameters influenced by the variation in iron content (IC) in muscle. Samples of Longissimus dorsi (LD) muscle from Nelore cattle (n = 8), extreme genomic estimated breeding value (GEBV) for IC (four samples with high (HIL) and four low (LIL) GEBV) were used. Data analysis by Tuxedo Suite identified 49 annotated genes DE between the groups. The functional enrichment analysis identified important metabolic pathways associated with lipid metabolism, like stearate biosynthesis, fatty acid biosynthesis and palmitate biosynthesis, which participate in the gene FASN, FABP4, SLC27A6 and THRSP. These results suggest biologic pathways influenced by iron and contribute information for the understanding of their participation in the process that affects muscle physiology in cattle. |
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Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers.Iron metabolismLongissimus dorsiFatty acidsGene expressionIron is essential to several biological processes, such as oxygen transport and lipid metabolism. In this study, the RNA sequencing technology (RNAseq) was adopted to identify differentially expressed genes (DE) and metabolic pathways, as well as its relationship with meat quality parameters influenced by the variation in iron content (IC) in muscle. Samples of Longissimus dorsi (LD) muscle from Nelore cattle (n = 8), extreme genomic estimated breeding value (GEBV) for IC (four samples with high (HIL) and four low (LIL) GEBV) were used. Data analysis by Tuxedo Suite identified 49 annotated genes DE between the groups. The functional enrichment analysis identified important metabolic pathways associated with lipid metabolism, like stearate biosynthesis, fatty acid biosynthesis and palmitate biosynthesis, which participate in the gene FASN, FABP4, SLC27A6 and THRSP. These results suggest biologic pathways influenced by iron and contribute information for the understanding of their participation in the process that affects muscle physiology in cattle.WELLISON JARLES DA SILVA DINIZ, Federal University of São Carlos; POLYANA CRISTINE TIZIOTO; LUIZ LEHMANN COUTINHO, University of São Paulo; ALINE SILVA MELLO CESAR, University of São Paulo; CAIO FERNANDO GROMBONI, Bahia Federal Institute of Education; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.DINIZ, W. J. DA S.TIZIOTO, P. C.COUTINHO, L. L.CESAR, A. S. M.GROMBONI, C. F.NOGUEIRA, A. R. de A.REGITANO, L. C. de A.2023-06-15T18:24:38Z2023-06-15T18:24:38Z2023-06-152015Artigo em anais e proceedingsinfo:eu-repo/semantics/publishedVersionIn: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 52., Belo Horizonte, 2015. Anais... Belo Horizonte: SBZ, 2015.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1154455enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2023-06-15T18:24:38Zoai:www.alice.cnptia.embrapa.br:doc/1154455Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542023-06-15T18:24:38Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
title |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
spellingShingle |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. DINIZ, W. J. DA S. Iron metabolism Longissimus dorsi Fatty acids Gene expression |
title_short |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
title_full |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
title_fullStr |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
title_full_unstemmed |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
title_sort |
Transcriptomic analysis identifies differentially expressed genes related to lipid metabolism in extreme animals for GEBV for iron content in the muscle Nelore steers. |
author |
DINIZ, W. J. DA S. |
author_facet |
DINIZ, W. J. DA S. TIZIOTO, P. C. COUTINHO, L. L. CESAR, A. S. M. GROMBONI, C. F. NOGUEIRA, A. R. de A. REGITANO, L. C. de A. |
author_role |
author |
author2 |
TIZIOTO, P. C. COUTINHO, L. L. CESAR, A. S. M. GROMBONI, C. F. NOGUEIRA, A. R. de A. REGITANO, L. C. de A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
WELLISON JARLES DA SILVA DINIZ, Federal University of São Carlos; POLYANA CRISTINE TIZIOTO; LUIZ LEHMANN COUTINHO, University of São Paulo; ALINE SILVA MELLO CESAR, University of São Paulo; CAIO FERNANDO GROMBONI, Bahia Federal Institute of Education; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
dc.contributor.author.fl_str_mv |
DINIZ, W. J. DA S. TIZIOTO, P. C. COUTINHO, L. L. CESAR, A. S. M. GROMBONI, C. F. NOGUEIRA, A. R. de A. REGITANO, L. C. de A. |
dc.subject.por.fl_str_mv |
Iron metabolism Longissimus dorsi Fatty acids Gene expression |
topic |
Iron metabolism Longissimus dorsi Fatty acids Gene expression |
description |
Iron is essential to several biological processes, such as oxygen transport and lipid metabolism. In this study, the RNA sequencing technology (RNAseq) was adopted to identify differentially expressed genes (DE) and metabolic pathways, as well as its relationship with meat quality parameters influenced by the variation in iron content (IC) in muscle. Samples of Longissimus dorsi (LD) muscle from Nelore cattle (n = 8), extreme genomic estimated breeding value (GEBV) for IC (four samples with high (HIL) and four low (LIL) GEBV) were used. Data analysis by Tuxedo Suite identified 49 annotated genes DE between the groups. The functional enrichment analysis identified important metabolic pathways associated with lipid metabolism, like stearate biosynthesis, fatty acid biosynthesis and palmitate biosynthesis, which participate in the gene FASN, FABP4, SLC27A6 and THRSP. These results suggest biologic pathways influenced by iron and contribute information for the understanding of their participation in the process that affects muscle physiology in cattle. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2023-06-15T18:24:38Z 2023-06-15T18:24:38Z 2023-06-15 |
dc.type.driver.fl_str_mv |
Artigo em anais e proceedings |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 52., Belo Horizonte, 2015. Anais... Belo Horizonte: SBZ, 2015. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1154455 |
identifier_str_mv |
In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 52., Belo Horizonte, 2015. Anais... Belo Horizonte: SBZ, 2015. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1154455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1817695675291271168 |