Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.

Detalhes bibliográficos
Autor(a) principal: GUIMARÃES-SANTOS, A.
Data de Publicação: 2012
Outros Autores: LAMEIRA, O. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/950612
Resumo: The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-in?ammatory and healing agent. However, there are no investigations on the possible anti-in?ammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-in?ammatory and neuroprotective e?ects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating in?ammatory response following an acute damage to the central nervous system.
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spelling Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.Óleo resinaCopaibaPlanta medicinalThe oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-in?ammatory and healing agent. However, there are no investigations on the possible anti-in?ammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-in?ammatory and neuroprotective e?ects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating in?ammatory response following an acute damage to the central nervous system.Adriano Guimarães-Santos, UFPA; OSMAR ALVES LAMEIRA, CPATU.GUIMARÃES-SANTOS, A.LAMEIRA, O. A.2013-02-22T11:11:11Z2013-02-22T11:11:11Z2013-02-2220122015-04-08T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEvidence-Based Complementary and Alternative Medicine, v. 2012, p. 1-9, 2012.http://www.alice.cnptia.embrapa.br/alice/handle/doc/950612enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-16T02:04:25Zoai:www.alice.cnptia.embrapa.br:doc/950612Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-16T02:04:25Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
title Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
spellingShingle Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
GUIMARÃES-SANTOS, A.
Óleo resina
Copaiba
Planta medicinal
title_short Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
title_full Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
title_fullStr Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
title_full_unstemmed Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
title_sort Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
author GUIMARÃES-SANTOS, A.
author_facet GUIMARÃES-SANTOS, A.
LAMEIRA, O. A.
author_role author
author2 LAMEIRA, O. A.
author2_role author
dc.contributor.none.fl_str_mv Adriano Guimarães-Santos, UFPA; OSMAR ALVES LAMEIRA, CPATU.
dc.contributor.author.fl_str_mv GUIMARÃES-SANTOS, A.
LAMEIRA, O. A.
dc.subject.por.fl_str_mv Óleo resina
Copaiba
Planta medicinal
topic Óleo resina
Copaiba
Planta medicinal
description The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-in?ammatory and healing agent. However, there are no investigations on the possible anti-in?ammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-in?ammatory and neuroprotective e?ects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating in?ammatory response following an acute damage to the central nervous system.
publishDate 2012
dc.date.none.fl_str_mv 2012
2013-02-22T11:11:11Z
2013-02-22T11:11:11Z
2013-02-22
2015-04-08T11:11:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Evidence-Based Complementary and Alternative Medicine, v. 2012, p. 1-9, 2012.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/950612
identifier_str_mv Evidence-Based Complementary and Alternative Medicine, v. 2012, p. 1-9, 2012.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/950612
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
_version_ 1817695280483532800

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