Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.

Detalhes bibliográficos
Autor(a) principal: SOUSA, A. R. de
Data de Publicação: 2018
Outros Autores: MOREIRA, M. E. de C., TOLEDO, R. C. L., BENJAMIN, L. dos A., QUEIROZ, V. A. V., VELOSO, M. P., REIS, K. de S., MARTINO, H. S. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106325
Resumo: The study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor (PPAR), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the a?nity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-?receptor. Histological analysis con?rmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity.
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spelling Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.AdipogenéticaComposto bioativoAntocianinaEsteatoseThe study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor (PPAR), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the a?nity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-?receptor. Histological analysis con?rmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity.Andressa Rodrigues de Sousa, Universidade Federal de Viçosa; Maria Eliza de Castro Moreiraa, Universidade Federal de Viçosa; Renata Celi Lopes Toledo, Universidade Federal de Viçosa; Laércio dos Anjos Benjamin, Universidade Federal de Viçosa; VALERIA APARECIDA VIEIRA QUEIROZ, CNPMS; Marcia Paranho Veloso, Universidade Federal de Alfenas; Kassius de Souza Reis, Universidade Federal de Alfenas; Hércia Stampini Duarte Martino, Universidade Federal de Viçosa.SOUSA, A. R. deMOREIRA, M. E. de C.TOLEDO, R. C. L.BENJAMIN, L. dos A.QUEIROZ, V. A. V.VELOSO, M. P.REIS, K. de S.MARTINO, H. S. D.2019-02-22T00:34:23Z2019-02-22T00:34:23Z2019-02-2120182019-02-22T00:34:23Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFood Research International, v. 112, p. 48-55, 2018.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106325enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2019-02-22T00:34:30Zoai:www.alice.cnptia.embrapa.br:doc/1106325Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542019-02-22T00:34:30falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542019-02-22T00:34:30Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
title Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
spellingShingle Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
SOUSA, A. R. de
Adipogenética
Composto bioativo
Antocianina
Esteatose
title_short Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
title_full Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
title_fullStr Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
title_full_unstemmed Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
title_sort Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet.
author SOUSA, A. R. de
author_facet SOUSA, A. R. de
MOREIRA, M. E. de C.
TOLEDO, R. C. L.
BENJAMIN, L. dos A.
QUEIROZ, V. A. V.
VELOSO, M. P.
REIS, K. de S.
MARTINO, H. S. D.
author_role author
author2 MOREIRA, M. E. de C.
TOLEDO, R. C. L.
BENJAMIN, L. dos A.
QUEIROZ, V. A. V.
VELOSO, M. P.
REIS, K. de S.
MARTINO, H. S. D.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Andressa Rodrigues de Sousa, Universidade Federal de Viçosa; Maria Eliza de Castro Moreiraa, Universidade Federal de Viçosa; Renata Celi Lopes Toledo, Universidade Federal de Viçosa; Laércio dos Anjos Benjamin, Universidade Federal de Viçosa; VALERIA APARECIDA VIEIRA QUEIROZ, CNPMS; Marcia Paranho Veloso, Universidade Federal de Alfenas; Kassius de Souza Reis, Universidade Federal de Alfenas; Hércia Stampini Duarte Martino, Universidade Federal de Viçosa.
dc.contributor.author.fl_str_mv SOUSA, A. R. de
MOREIRA, M. E. de C.
TOLEDO, R. C. L.
BENJAMIN, L. dos A.
QUEIROZ, V. A. V.
VELOSO, M. P.
REIS, K. de S.
MARTINO, H. S. D.
dc.subject.por.fl_str_mv Adipogenética
Composto bioativo
Antocianina
Esteatose
topic Adipogenética
Composto bioativo
Antocianina
Esteatose
description The study investigated the effect of extruded sorghum flour (ESF) in a high fat diet (HFD) on biometric measurements and hepatic lipogenesis. Male Wistar rats were fed a normal diet (AIN-93M), HFD, HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50), or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100) for eight weeks. ESF reduced the body mass index and liver weight of obese rats. Additionally, ESF reduced hepatic lipogenesis by increasing adiponectin 2 receptor gene expression and gene and protein expressions of peroxisome proliferator-activated receptor (PPAR), while reducing the gene expression of sterol regulatory element-binding transcription factor 1. Molecular docking analysis revealed the a?nity of ESF compounds (luteolinidin, apigeninidin, 5-methoxy-luteolinidin, and 7-methoxy-apigeninidin) with the PPAR-?receptor. Histological analysis con?rmed the decreased grade of hepatic steatosis in obese rats. These data indicate the potential of ESF to reduce metabolic risk of hepatic steatosis associated with lipogenesis and obesity.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019-02-22T00:34:23Z
2019-02-22T00:34:23Z
2019-02-21
2019-02-22T00:34:23Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Food Research International, v. 112, p. 48-55, 2018.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106325
identifier_str_mv Food Research International, v. 112, p. 48-55, 2018.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1106325
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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