Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth.
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/965349 |
Resumo: | Croton cajucara is a shrub native to the Amazon region locally known as ?sacaca?. Two morphotypes are known: white and red ?sacaca?. The essential oils (EO) obtained by hydrodistillation from leaves of the red morphotype were, in general, rich in 7-hydroxycalamenene (28.4%?37.5%). The effectiveness of these EO regarding the antimicrobial activity against pathogenic microorganisms was initially investigated by the drop test method, showing significant inhibition zones. Among the microorganisms tested, the essential oils rich in 7-hydroxycalamenene were more effective against methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Mycobacterium tuberculosis, M. smegmatis, Mucor circinelloides and Rhizopus oryzae. The minimum inhibitory concentrations (MIC) of the oils were determined using the broth dilution assay. It was possible to observe that 7-hydroxycalamenene-rich oils presented high antimicrobial activity, with MIC of 4.76 × 10−3 μg/mL for MRSA, 4.88 μg/mL for M. tuberculosis, 39.06 μg/mL for M. smegmatis, and 0.152 μg/mL for R. oryzae and 3.63 × 10−8 μg/mL for M. circinelloides. The antioxidant activity of this EO suggests that 7-hydroxycalamenene provides more antioxidant activity according with EC50 less than 63.59 μg/mL. Considering the bioactive potential of EOs and 7-hydroxycalamenene could be of great interest for development of antimicrobials for therapeutic use in treatment of bacterial and fungal infections in humans and/or veterinary practice. |
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Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth.Óleos essenciaisAtividade antimicrobianaAtividade antioxidanteCroton cajucaraCroton cajucara is a shrub native to the Amazon region locally known as ?sacaca?. Two morphotypes are known: white and red ?sacaca?. The essential oils (EO) obtained by hydrodistillation from leaves of the red morphotype were, in general, rich in 7-hydroxycalamenene (28.4%?37.5%). The effectiveness of these EO regarding the antimicrobial activity against pathogenic microorganisms was initially investigated by the drop test method, showing significant inhibition zones. Among the microorganisms tested, the essential oils rich in 7-hydroxycalamenene were more effective against methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Mycobacterium tuberculosis, M. smegmatis, Mucor circinelloides and Rhizopus oryzae. The minimum inhibitory concentrations (MIC) of the oils were determined using the broth dilution assay. It was possible to observe that 7-hydroxycalamenene-rich oils presented high antimicrobial activity, with MIC of 4.76 × 10−3 μg/mL for MRSA, 4.88 μg/mL for M. tuberculosis, 39.06 μg/mL for M. smegmatis, and 0.152 μg/mL for R. oryzae and 3.63 × 10−8 μg/mL for M. circinelloides. The antioxidant activity of this EO suggests that 7-hydroxycalamenene provides more antioxidant activity according with EC50 less than 63.59 μg/mL. Considering the bioactive potential of EOs and 7-hydroxycalamenene could be of great interest for development of antimicrobials for therapeutic use in treatment of bacterial and fungal infections in humans and/or veterinary practice.MARIANA M. B. AZEVEDO, UFRJ; FRANCISCO CELIO MAIA CHAVES, CPAA; CATIA A. ALMEIDA, UFRJ; HUMBERTO RIBEIRO BIZZO, CTAA; RAFAEL S. DUARTE, UFRJ; GALBA M. CAMPOS-TAKAKI, UFPE; CELUTA S. ALVIANO, UFRJ; DANIELA S. ALVIANO, UFRJ.AZEVEDO, M. M. B.CHAVES, F. C. M.ALMEIDA, C. A.BIZZO, H. R.DUARTE, R. S.CAMPOS-TAKAKI, G. M.ALVIANO, C. S.ALVIANO, D. S.2013-09-02T11:11:11Z2013-09-02T11:11:11Z2013-09-0220132016-02-22T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMolecules, v. 18, n. 1, p. 1128-1137, Jan. 2013.http://www.alice.cnptia.embrapa.br/alice/handle/doc/96534910.3390/molecules18011128enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-16T00:57:01Zoai:www.alice.cnptia.embrapa.br:doc/965349Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542017-08-16T00:57:01falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-16T00:57:01Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
title |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
spellingShingle |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. AZEVEDO, M. M. B. Óleos essenciais Atividade antimicrobiana Atividade antioxidante Croton cajucara |
title_short |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
title_full |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
title_fullStr |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
title_full_unstemmed |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
title_sort |
Antioxidant and antimicrobial activities of 7-hydroxycalamenene-rich essential oils from Croton cajucara Benth. |
author |
AZEVEDO, M. M. B. |
author_facet |
AZEVEDO, M. M. B. CHAVES, F. C. M. ALMEIDA, C. A. BIZZO, H. R. DUARTE, R. S. CAMPOS-TAKAKI, G. M. ALVIANO, C. S. ALVIANO, D. S. |
author_role |
author |
author2 |
CHAVES, F. C. M. ALMEIDA, C. A. BIZZO, H. R. DUARTE, R. S. CAMPOS-TAKAKI, G. M. ALVIANO, C. S. ALVIANO, D. S. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
MARIANA M. B. AZEVEDO, UFRJ; FRANCISCO CELIO MAIA CHAVES, CPAA; CATIA A. ALMEIDA, UFRJ; HUMBERTO RIBEIRO BIZZO, CTAA; RAFAEL S. DUARTE, UFRJ; GALBA M. CAMPOS-TAKAKI, UFPE; CELUTA S. ALVIANO, UFRJ; DANIELA S. ALVIANO, UFRJ. |
dc.contributor.author.fl_str_mv |
AZEVEDO, M. M. B. CHAVES, F. C. M. ALMEIDA, C. A. BIZZO, H. R. DUARTE, R. S. CAMPOS-TAKAKI, G. M. ALVIANO, C. S. ALVIANO, D. S. |
dc.subject.por.fl_str_mv |
Óleos essenciais Atividade antimicrobiana Atividade antioxidante Croton cajucara |
topic |
Óleos essenciais Atividade antimicrobiana Atividade antioxidante Croton cajucara |
description |
Croton cajucara is a shrub native to the Amazon region locally known as ?sacaca?. Two morphotypes are known: white and red ?sacaca?. The essential oils (EO) obtained by hydrodistillation from leaves of the red morphotype were, in general, rich in 7-hydroxycalamenene (28.4%?37.5%). The effectiveness of these EO regarding the antimicrobial activity against pathogenic microorganisms was initially investigated by the drop test method, showing significant inhibition zones. Among the microorganisms tested, the essential oils rich in 7-hydroxycalamenene were more effective against methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Mycobacterium tuberculosis, M. smegmatis, Mucor circinelloides and Rhizopus oryzae. The minimum inhibitory concentrations (MIC) of the oils were determined using the broth dilution assay. It was possible to observe that 7-hydroxycalamenene-rich oils presented high antimicrobial activity, with MIC of 4.76 × 10−3 μg/mL for MRSA, 4.88 μg/mL for M. tuberculosis, 39.06 μg/mL for M. smegmatis, and 0.152 μg/mL for R. oryzae and 3.63 × 10−8 μg/mL for M. circinelloides. The antioxidant activity of this EO suggests that 7-hydroxycalamenene provides more antioxidant activity according with EC50 less than 63.59 μg/mL. Considering the bioactive potential of EOs and 7-hydroxycalamenene could be of great interest for development of antimicrobials for therapeutic use in treatment of bacterial and fungal infections in humans and/or veterinary practice. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-02T11:11:11Z 2013-09-02T11:11:11Z 2013-09-02 2013 2016-02-22T11:11:11Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Molecules, v. 18, n. 1, p. 1128-1137, Jan. 2013. http://www.alice.cnptia.embrapa.br/alice/handle/doc/965349 10.3390/molecules18011128 |
identifier_str_mv |
Molecules, v. 18, n. 1, p. 1128-1137, Jan. 2013. 10.3390/molecules18011128 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/965349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
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EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503381504491520 |