Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery.
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1153621 https://doi.org/10.3390/molecules27217271 |
Resumo: | Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity. |
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Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery.Carboxymethyl starchBioactive agent deliveryMonolithic tabletsJamelãoAgente bioativoAntioxidantesAntitumoralAntiateroscleróticaAntioxidant activitiesAntiinflammatoryAntiatherosclerotic activitiesFrutoAntiinflamatórioAnthocyaninsSyzygium cuminiFruit compositionAnthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University.SABINO, L. B. de S.COPES, F.SAULAIS, S.BRITO, E. S. deSILVA JÚNIOR, I. J. daLE, T. C.MATEESCU, M. A.MANTOVANI, D.2023-05-10T05:55:51Z2023-05-10T05:55:51Z2023-05-092022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMolecules, v. 27, n. 21, 7271, p. 1-19, 2022.1420-3049http://www.alice.cnptia.embrapa.br/alice/handle/doc/1153621https://doi.org/10.3390/molecules27217271enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2023-05-10T05:55:51Zoai:www.alice.cnptia.embrapa.br:doc/1153621Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542023-05-10T05:55:51falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542023-05-10T05:55:51Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
title |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
spellingShingle |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. SABINO, L. B. de S. Carboxymethyl starch Bioactive agent delivery Monolithic tablets Jamelão Agente bioativo Antioxidantes Antitumoral Antiaterosclerótica Antioxidant activities Antiinflammatory Antiatherosclerotic activities Fruto Antiinflamatório Anthocyanins Syzygium cumini Fruit composition |
title_short |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
title_full |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
title_fullStr |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
title_full_unstemmed |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
title_sort |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
author |
SABINO, L. B. de S. |
author_facet |
SABINO, L. B. de S. COPES, F. SAULAIS, S. BRITO, E. S. de SILVA JÚNIOR, I. J. da LE, T. C. MATEESCU, M. A. MANTOVANI, D. |
author_role |
author |
author2 |
COPES, F. SAULAIS, S. BRITO, E. S. de SILVA JÚNIOR, I. J. da LE, T. C. MATEESCU, M. A. MANTOVANI, D. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University. |
dc.contributor.author.fl_str_mv |
SABINO, L. B. de S. COPES, F. SAULAIS, S. BRITO, E. S. de SILVA JÚNIOR, I. J. da LE, T. C. MATEESCU, M. A. MANTOVANI, D. |
dc.subject.por.fl_str_mv |
Carboxymethyl starch Bioactive agent delivery Monolithic tablets Jamelão Agente bioativo Antioxidantes Antitumoral Antiaterosclerótica Antioxidant activities Antiinflammatory Antiatherosclerotic activities Fruto Antiinflamatório Anthocyanins Syzygium cumini Fruit composition |
topic |
Carboxymethyl starch Bioactive agent delivery Monolithic tablets Jamelão Agente bioativo Antioxidantes Antitumoral Antiaterosclerótica Antioxidant activities Antiinflammatory Antiatherosclerotic activities Fruto Antiinflamatório Anthocyanins Syzygium cumini Fruit composition |
description |
Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2023-05-10T05:55:51Z 2023-05-10T05:55:51Z 2023-05-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Molecules, v. 27, n. 21, 7271, p. 1-19, 2022. 1420-3049 http://www.alice.cnptia.embrapa.br/alice/handle/doc/1153621 https://doi.org/10.3390/molecules27217271 |
identifier_str_mv |
Molecules, v. 27, n. 21, 7271, p. 1-19, 2022. 1420-3049 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1153621 https://doi.org/10.3390/molecules27217271 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503544601051136 |