Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563 |
Resumo: | Abstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value<.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits. |
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Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.Ração residualEtapa única ponderadaGadoGanho de PesoAbstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value<.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits.LUDMILLA C. BRUNES; FERNANDO BALDI; FERNANDO B. LOPES; RAYSILDO B. LÔBO; RAFAEL ESPIGOLAN; MARCOS FERNANDO OLIVEIRA E COSTA, CNPAF; NEDENIA B. STAFUZZA; CLAUDIO DE ULHOA MAGNABOSCO, CPAC.BRUNES, L. C.BALDI, F.LOPES, F. B.LOBO, R. B.ESPIGOLAN, R.COSTA, M. F. O. eSTAFUZZA, N. B.MAGNABOSCO, C. de U.2021-11-25T15:00:25Z2021-11-25T15:00:25Z2021-11-252021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJournal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2021-11-25T15:00:36Zoai:www.alice.cnptia.embrapa.br:doc/1136563Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542021-11-25T15:00:36falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542021-11-25T15:00:36Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
title |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
spellingShingle |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. BRUNES, L. C. Ração residual Etapa única ponderada Gado Ganho de Peso |
title_short |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
title_full |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
title_fullStr |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
title_full_unstemmed |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
title_sort |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
author |
BRUNES, L. C. |
author_facet |
BRUNES, L. C. BALDI, F. LOPES, F. B. LOBO, R. B. ESPIGOLAN, R. COSTA, M. F. O. e STAFUZZA, N. B. MAGNABOSCO, C. de U. |
author_role |
author |
author2 |
BALDI, F. LOPES, F. B. LOBO, R. B. ESPIGOLAN, R. COSTA, M. F. O. e STAFUZZA, N. B. MAGNABOSCO, C. de U. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
LUDMILLA C. BRUNES; FERNANDO BALDI; FERNANDO B. LOPES; RAYSILDO B. LÔBO; RAFAEL ESPIGOLAN; MARCOS FERNANDO OLIVEIRA E COSTA, CNPAF; NEDENIA B. STAFUZZA; CLAUDIO DE ULHOA MAGNABOSCO, CPAC. |
dc.contributor.author.fl_str_mv |
BRUNES, L. C. BALDI, F. LOPES, F. B. LOBO, R. B. ESPIGOLAN, R. COSTA, M. F. O. e STAFUZZA, N. B. MAGNABOSCO, C. de U. |
dc.subject.por.fl_str_mv |
Ração residual Etapa única ponderada Gado Ganho de Peso |
topic |
Ração residual Etapa única ponderada Gado Ganho de Peso |
description |
Abstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value<.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-25T15:00:25Z 2021-11-25T15:00:25Z 2021-11-25 2021 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563 |
identifier_str_mv |
Journal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503512532451328 |