Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.

Detalhes bibliográficos
Autor(a) principal: BRUNES, L. C.
Data de Publicação: 2021
Outros Autores: BALDI, F., LOPES, F. B., LOBO, R. B., ESPIGOLAN, R., COSTA, M. F. O. e, STAFUZZA, N. B., MAGNABOSCO, C. de U.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563
Resumo: Abstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value&#57375;<&#57375;.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits.
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spelling Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.Ração residualEtapa única ponderadaGadoGanho de PesoAbstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value&#57375;<&#57375;.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits.LUDMILLA C. BRUNES; FERNANDO BALDI; FERNANDO B. LOPES; RAYSILDO B. LÔBO; RAFAEL ESPIGOLAN; MARCOS FERNANDO OLIVEIRA E COSTA, CNPAF; NEDENIA B. STAFUZZA; CLAUDIO DE ULHOA MAGNABOSCO, CPAC.BRUNES, L. C.BALDI, F.LOPES, F. B.LOBO, R. B.ESPIGOLAN, R.COSTA, M. F. O. eSTAFUZZA, N. B.MAGNABOSCO, C. de U.2021-11-25T15:00:25Z2021-11-25T15:00:25Z2021-11-252021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJournal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2021-11-25T15:00:36Zoai:www.alice.cnptia.embrapa.br:doc/1136563Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542021-11-25T15:00:36falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542021-11-25T15:00:36Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
title Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
spellingShingle Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
BRUNES, L. C.
Ração residual
Etapa única ponderada
Gado
Ganho de Peso
title_short Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
title_full Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
title_fullStr Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
title_full_unstemmed Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
title_sort Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
author BRUNES, L. C.
author_facet BRUNES, L. C.
BALDI, F.
LOPES, F. B.
LOBO, R. B.
ESPIGOLAN, R.
COSTA, M. F. O. e
STAFUZZA, N. B.
MAGNABOSCO, C. de U.
author_role author
author2 BALDI, F.
LOPES, F. B.
LOBO, R. B.
ESPIGOLAN, R.
COSTA, M. F. O. e
STAFUZZA, N. B.
MAGNABOSCO, C. de U.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LUDMILLA C. BRUNES; FERNANDO BALDI; FERNANDO B. LOPES; RAYSILDO B. LÔBO; RAFAEL ESPIGOLAN; MARCOS FERNANDO OLIVEIRA E COSTA, CNPAF; NEDENIA B. STAFUZZA; CLAUDIO DE ULHOA MAGNABOSCO, CPAC.
dc.contributor.author.fl_str_mv BRUNES, L. C.
BALDI, F.
LOPES, F. B.
LOBO, R. B.
ESPIGOLAN, R.
COSTA, M. F. O. e
STAFUZZA, N. B.
MAGNABOSCO, C. de U.
dc.subject.por.fl_str_mv Ração residual
Etapa única ponderada
Gado
Ganho de Peso
topic Ração residual
Etapa única ponderada
Gado
Ganho de Peso
description Abstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value&#57375;<&#57375;.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-25T15:00:25Z
2021-11-25T15:00:25Z
2021-11-25
2021
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Journal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563
identifier_str_mv Journal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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