Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jbg.12496 http://hdl.handle.net/11449/199085 |
Resumo: | The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p-value <.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE-related traits. |
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Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattleBos indicusGBLUPresidual body weight gainresidual feed intakeweighted single-stepThe aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p-value <.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE-related traits.Department of Animal Science Federal University of Goiás (UFG)Embrapa Rice and Beans Santo Antônio de GoiásDepartment of Animal Science São Paulo State University (UNESP)Cobb-Vantress Inc.National Association of Breeders and Researchers (ANCP)Department of Veterinary Medicine Faculty of Animal Science and Food Engineering University of Sao PauloBeef Cattle Research Center Animal Science InstituteEmbrapa CerradosDepartment of Animal Science São Paulo State University (UNESP)Universidade Federal de Goiás (UFG)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Estadual Paulista (Unesp)Inc.National Association of Breeders and Researchers (ANCP)Universidade de São Paulo (USP)Animal Science InstituteBrunes, Ludmilla C.Baldi, Fernando [UNESP]Lopes, Fernando B.Lôbo, Raysildo B.Espigolan, RafaelCosta, Marcos F. O.Stafuzza, Nedenia B.Magnabosco, Cláudio U.2020-12-12T01:30:23Z2020-12-12T01:30:23Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/jbg.12496Journal of Animal Breeding and Genetics.1439-03880931-2668http://hdl.handle.net/11449/19908510.1111/jbg.124962-s2.0-85087667854Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Animal Breeding and Geneticsinfo:eu-repo/semantics/openAccess2021-10-23T03:03:25Zoai:repositorio.unesp.br:11449/199085Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T03:03:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
title |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
spellingShingle |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle Brunes, Ludmilla C. Bos indicus GBLUP residual body weight gain residual feed intake weighted single-step |
title_short |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
title_full |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
title_fullStr |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
title_full_unstemmed |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
title_sort |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle |
author |
Brunes, Ludmilla C. |
author_facet |
Brunes, Ludmilla C. Baldi, Fernando [UNESP] Lopes, Fernando B. Lôbo, Raysildo B. Espigolan, Rafael Costa, Marcos F. O. Stafuzza, Nedenia B. Magnabosco, Cláudio U. |
author_role |
author |
author2 |
Baldi, Fernando [UNESP] Lopes, Fernando B. Lôbo, Raysildo B. Espigolan, Rafael Costa, Marcos F. O. Stafuzza, Nedenia B. Magnabosco, Cláudio U. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Universidade Estadual Paulista (Unesp) Inc. National Association of Breeders and Researchers (ANCP) Universidade de São Paulo (USP) Animal Science Institute |
dc.contributor.author.fl_str_mv |
Brunes, Ludmilla C. Baldi, Fernando [UNESP] Lopes, Fernando B. Lôbo, Raysildo B. Espigolan, Rafael Costa, Marcos F. O. Stafuzza, Nedenia B. Magnabosco, Cláudio U. |
dc.subject.por.fl_str_mv |
Bos indicus GBLUP residual body weight gain residual feed intake weighted single-step |
topic |
Bos indicus GBLUP residual body weight gain residual feed intake weighted single-step |
description |
The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p-value <.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE-related traits. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:30:23Z 2020-12-12T01:30:23Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jbg.12496 Journal of Animal Breeding and Genetics. 1439-0388 0931-2668 http://hdl.handle.net/11449/199085 10.1111/jbg.12496 2-s2.0-85087667854 |
url |
http://dx.doi.org/10.1111/jbg.12496 http://hdl.handle.net/11449/199085 |
identifier_str_mv |
Journal of Animal Breeding and Genetics. 1439-0388 0931-2668 10.1111/jbg.12496 2-s2.0-85087667854 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Animal Breeding and Genetics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964756999667712 |