Epidemiological trends and clinical repercussions of transmitted resistance to HIV antiretroviral agents - integrative review

• Autor(a) principal: Ribeiro, Edlainny Araujo
• Data de Publicação: 2023
• Outros Autores: Oliveira, Mateus Eduardo de, Pinto, Andressa Raiany Henrique, Bastos, Adriany Ventura de, Ferreira, Ingrid Jordana Bernardes, Teixeira, Alanna Oliveira
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: Scire Salutis
• Texto Completo: https://sustenere.inf.br/index.php/sciresalutis/article/view/7931
• topic: Resistência Transmitida a Medicamentos; Vigilância de Resistência a Medicamentos para HIV; Resistência ao HIV; Resistência a Pré-tratamento de Medicamentos para HIV; Transmitted Drug Resistance; HIV Drug Resistance Surveillance; HIV Drug Resistance; Pretreatment HIV Drug Resistance

The Human Immunodeficiency Virus (HIV) is a retrovirus of the Retroviridae family that affects CD4+ T lymphocytes and triggers immunosuppression in the infected individual, thus enabling opportunistic infections (OIs). However, in addition to the immunological perspective, the scenario of HIV transmitted drug resistance (TDR) is a growing and current problem that may worsen the current scenario of this infection. The objective of this research was to analyze the scientific evidence and describe the main trends and epidemiological repercussions of HIV RDT, as well as the inherent damage to the health of affected patients. This is an integrative literature review with a search in the Public Medline or Publisher Medline database (PubMed/MEDLINE) with descriptors and keywords combined by the Boolean operator “AND” and “OR”, obtained by consulting the Science Descriptors in Health (DECS) and in articles already published. After applying a flowchart for selection, 11 original articles published from 2017 to 2022 were included. The main clinical impacts associated with RDT were limitations in the choice and response of available first-line therapies, as well as a decrease in virological suppression rates in therapy. Due to the impacts and clinical repercussions inherent to this problem, the importance of implementing screening and control of this type of resistance is systematically highlighted, as well as carrying out surveillance studies on TDR and outcomes in the course of the infection, especially in areas with more limited resources.