The influence of the MAOA gene on mental disorders of the individual

Detalhes bibliográficos
Autor(a) principal: Viegas, Elaine
Data de Publicação: 2023
Outros Autores: Bonasser, Larissa Sousa Silva, Seixas, Gabriel Moura Alves, Silva, Izabel Cristina Rodrigues da
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: REVISA : Revista de Divulgação Científica Sena Aires (Online)
Texto Completo: https://rdcsa.emnuvens.com.br/revista/article/view/115
Resumo: Objective: To review and discuss scientific studies that seek the association of the polymorphism of the MAOA gene, of the uVNTR type, with mental disorders in adults. Method: An integrative review was performed according to the PRISMA model. The research followed the stages of formulation of the research question, selection of reference search databases, definition of the search strategy, evaluation of the eligibility of studies, screening and selection of articles, data extraction and compilation of results. Results: We selected 12 original articles that reported the u-VNTR polymorphism and its alleles of 2, 3, 3.5, 4 and 5 repeats in the MAOA gene, and its association with psychic disorders. Conclusion: The polymorphism of the MAOA gene of the uVNTR type is related to the functionality of the MAOA enzyme, increasing or decreasing its activity, raising or decreasing the levels of dopamine, serotonin or noradrenaline, and these changes are related to several mental disorders, such as schizophrenia, depression, aggressive antisocial behaviors, anxiety, attention deficit hyperactivity disorder (ADHD),  autism spectrum disorder and other disorders related to the expression of these neurotransmitters.
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spelling The influence of the MAOA gene on mental disorders of the individualA influência do gene MAOA em desordens mentais do indivíduoMAOAPolimorfismoDesordens MentaisMAOAPolymorphismMental DisordersObjective: To review and discuss scientific studies that seek the association of the polymorphism of the MAOA gene, of the uVNTR type, with mental disorders in adults. Method: An integrative review was performed according to the PRISMA model. The research followed the stages of formulation of the research question, selection of reference search databases, definition of the search strategy, evaluation of the eligibility of studies, screening and selection of articles, data extraction and compilation of results. Results: We selected 12 original articles that reported the u-VNTR polymorphism and its alleles of 2, 3, 3.5, 4 and 5 repeats in the MAOA gene, and its association with psychic disorders. Conclusion: The polymorphism of the MAOA gene of the uVNTR type is related to the functionality of the MAOA enzyme, increasing or decreasing its activity, raising or decreasing the levels of dopamine, serotonin or noradrenaline, and these changes are related to several mental disorders, such as schizophrenia, depression, aggressive antisocial behaviors, anxiety, attention deficit hyperactivity disorder (ADHD),  autism spectrum disorder and other disorders related to the expression of these neurotransmitters.Objetivo: Revisar e discorrer sobre os estudos científicos que buscam a associação do polimorfismo do gene MAOA, do tipo uVNTR, com distúrbios mentais em adultos. Método: Foi realizada uma revisão integrativa de acordo com o modelo PRISMA. A pesquisa seguiu as etapas de formulação da questão de pesquisa, seleção das bases de dados de busca de referências, definição da estratégia de busca, avaliação da elegibilidade dos estudos, triagem e seleção dos artigos, extração de dados e compilação dos resultados. Resultados: Foram selecionados 12 artigos originais que relataram o polimorfismo do tipo u-VNTR e seus alelos de 2, 3, 3,5, 4 e 5 repetições no gene MAOA, e sua associação com distúrbios psíquicos. Conclusão: O polimorfismo do gene MAOA do tipo uVNTR está relacionado com a funcionalidade da enzima MAOA, aumentando ou diminuindo sua atividade, elevando ou diminuindo os níveis de dopamina, serotonina ou noradrenalina, e essas alterações estão relacionados à diversos distúrbios mentais, como esquizofrenia, depressão, comportamentos agressivos antissociais, ansiedade, transtorno de déficit de atenção e hiperatividade (TDAH), transtorno do espectro autista e outros distúrbios relacionados à expressão desses neurotransmissores.Faculdade Evangélica de Valparaíso2023-10-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://rdcsa.emnuvens.com.br/revista/article/view/115Revista de Divulgação Científica Sena Aires; Vol. 12 No. 4 (2023): REVISA- Revista de Divulgação Científica Sena Aires; 786-799REVISA; v. 12 n. 4 (2023): REVISA- Revista de Divulgação Científica Sena Aires; 786-7992179-09812316-848Xreponame:REVISA : Revista de Divulgação Científica Sena Aires (Online)instname:Faculdade Evangélica de Valparaíso (Facev)instacron:FACEVporenghttps://rdcsa.emnuvens.com.br/revista/article/view/115/195https://rdcsa.emnuvens.com.br/revista/article/view/115/196Copyright (c) 2024 Revista de Divulgação Científica Sena Aireshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessViegas, ElaineBonasser, Larissa Sousa SilvaSeixas, Gabriel Moura AlvesSilva, Izabel Cristina Rodrigues da2024-05-31T19:41:21Zoai:ojs.rdcsa.emnuvens.com.br:article/115Revistahttps://rdcsa.emnuvens.com.br/revista/indexPRIhttps://rdcsa.emnuvens.com.br/revista/oairevisa@facev.com.br2179-09812179-0981opendoar:2024-05-31T19:41:21REVISA : Revista de Divulgação Científica Sena Aires (Online) - Faculdade Evangélica de Valparaíso (Facev)false
dc.title.none.fl_str_mv The influence of the MAOA gene on mental disorders of the individual
A influência do gene MAOA em desordens mentais do indivíduo
title The influence of the MAOA gene on mental disorders of the individual
spellingShingle The influence of the MAOA gene on mental disorders of the individual
Viegas, Elaine
MAOA
Polimorfismo
Desordens Mentais
MAOA
Polymorphism
Mental Disorders
title_short The influence of the MAOA gene on mental disorders of the individual
title_full The influence of the MAOA gene on mental disorders of the individual
title_fullStr The influence of the MAOA gene on mental disorders of the individual
title_full_unstemmed The influence of the MAOA gene on mental disorders of the individual
title_sort The influence of the MAOA gene on mental disorders of the individual
author Viegas, Elaine
author_facet Viegas, Elaine
Bonasser, Larissa Sousa Silva
Seixas, Gabriel Moura Alves
Silva, Izabel Cristina Rodrigues da
author_role author
author2 Bonasser, Larissa Sousa Silva
Seixas, Gabriel Moura Alves
Silva, Izabel Cristina Rodrigues da
author2_role author
author
author
dc.contributor.author.fl_str_mv Viegas, Elaine
Bonasser, Larissa Sousa Silva
Seixas, Gabriel Moura Alves
Silva, Izabel Cristina Rodrigues da
dc.subject.por.fl_str_mv MAOA
Polimorfismo
Desordens Mentais
MAOA
Polymorphism
Mental Disorders
topic MAOA
Polimorfismo
Desordens Mentais
MAOA
Polymorphism
Mental Disorders
description Objective: To review and discuss scientific studies that seek the association of the polymorphism of the MAOA gene, of the uVNTR type, with mental disorders in adults. Method: An integrative review was performed according to the PRISMA model. The research followed the stages of formulation of the research question, selection of reference search databases, definition of the search strategy, evaluation of the eligibility of studies, screening and selection of articles, data extraction and compilation of results. Results: We selected 12 original articles that reported the u-VNTR polymorphism and its alleles of 2, 3, 3.5, 4 and 5 repeats in the MAOA gene, and its association with psychic disorders. Conclusion: The polymorphism of the MAOA gene of the uVNTR type is related to the functionality of the MAOA enzyme, increasing or decreasing its activity, raising or decreasing the levels of dopamine, serotonin or noradrenaline, and these changes are related to several mental disorders, such as schizophrenia, depression, aggressive antisocial behaviors, anxiety, attention deficit hyperactivity disorder (ADHD),  autism spectrum disorder and other disorders related to the expression of these neurotransmitters.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rdcsa.emnuvens.com.br/revista/article/view/115
url https://rdcsa.emnuvens.com.br/revista/article/view/115
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rdcsa.emnuvens.com.br/revista/article/view/115/195
https://rdcsa.emnuvens.com.br/revista/article/view/115/196
dc.rights.driver.fl_str_mv Copyright (c) 2024 Revista de Divulgação Científica Sena Aires
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2024 Revista de Divulgação Científica Sena Aires
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Faculdade Evangélica de Valparaíso
publisher.none.fl_str_mv Faculdade Evangélica de Valparaíso
dc.source.none.fl_str_mv Revista de Divulgação Científica Sena Aires; Vol. 12 No. 4 (2023): REVISA- Revista de Divulgação Científica Sena Aires; 786-799
REVISA; v. 12 n. 4 (2023): REVISA- Revista de Divulgação Científica Sena Aires; 786-799
2179-0981
2316-848X
reponame:REVISA : Revista de Divulgação Científica Sena Aires (Online)
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instacron:FACEV
instname_str Faculdade Evangélica de Valparaíso (Facev)
instacron_str FACEV
institution FACEV
reponame_str REVISA : Revista de Divulgação Científica Sena Aires (Online)
collection REVISA : Revista de Divulgação Científica Sena Aires (Online)
repository.name.fl_str_mv REVISA : Revista de Divulgação Científica Sena Aires (Online) - Faculdade Evangélica de Valparaíso (Facev)
repository.mail.fl_str_mv revisa@facev.com.br
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