Association of chrogranin A (CHGA) genetic polymorphism with patients with thyroid câncer

• Autor(a) principal: Silva, Izabel Cristina Rodrigues da
• Data de Publicação: 2023
• Outros Autores: Gontijo, Bruna Rodrigues, Silva, Isabella Maria Leite e, Possatti, Isabella, Fratelli, Caroline Ferreira, Duarte, Ligia Canongia de Abreu Cardoso, Morais, Rafael Martins de, Oliveira, Jamila Reis de
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: REVISA : Revista de Divulgação Científica Sena Aires (Online)
• Texto Completo: https://rdcsa.emnuvens.com.br/revista/article/view/220
• topic: Cromogranina A; Polimorfismo Genético; Neoplasias da Glândula Tireoide; Chromogranin A; Genetic Polymorphism; Neoplasms of the Thyroid Gland

Objective: To describe the presence of polymorphism of the codante region of the CHGA Glu264Asp gene and to associate it with the clinical characteristics of the disease. Method: This is a cross-sectional, descriptive and case-control study to investigate chga glu264Asp polymorphism through blood samples from 53 individuals, consisting of 23 patients of both sexes who underwent thyroidectomy and underwent treatment with the Radiopharmaceutical Sodium Iodide (I131). Pcr-RFLP technique was used for genotyping. The significance level of 5% was adopted. Results: There was a statistically significant difference in the allelic distribution between individuals with papillary thyroid cancer and healthy individuals. With everything, the presence of the G alllet is a risk factor for papillary thyroid cancer. A correlation was observed between the GG genotype and the increased level of TSH in patients with this pathology. Conclusion: It was shown that the wild allomay be a risk factor for the development of the thyroid neoplasm of the papilar type. As it is a disease of multifactorial etiology, further studies in different populations are needed to better understand the disease.