The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de ginecologia e obstetrícia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016001100564 |
Resumo: | Abstract The overactive bladder (OAB) has a significant negative impact on the quality of life of patients. Antimuscarinics have become the pharmacological treatment of choice for this condition. The objective of this systematic review and meta-analysis is to examine the evidence from randomized clinical trials about the outcomes of the antimuscarinic drugs available in Brazil on OABs. We searched MEDLINE and the Cochrane Central Register of Controlled Trials from the inception of these databases through to September 2015. The primary outcome measures were the mean decrease in urge urinary incontinence episodes and the mean decrease in the frequency of micturition. The results suggest that there is a moderate to high amount of evidence supporting the benefit of using anticholinergic drugs in alleviating OAB symptoms when compared with placebo. It is still not clear whether any of the specific drugs that are available in Brazil offer advantages over the others. These drugs are associated with adverse effects (dry mouth and constipation), although they are not related to an increase in the number of withdrawals. |
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Revista brasileira de ginecologia e obstetrícia (Online) |
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The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysisoveractive bladderurge incontinenceurinary frequency and antimuscarinicsAbstract The overactive bladder (OAB) has a significant negative impact on the quality of life of patients. Antimuscarinics have become the pharmacological treatment of choice for this condition. The objective of this systematic review and meta-analysis is to examine the evidence from randomized clinical trials about the outcomes of the antimuscarinic drugs available in Brazil on OABs. We searched MEDLINE and the Cochrane Central Register of Controlled Trials from the inception of these databases through to September 2015. The primary outcome measures were the mean decrease in urge urinary incontinence episodes and the mean decrease in the frequency of micturition. The results suggest that there is a moderate to high amount of evidence supporting the benefit of using anticholinergic drugs in alleviating OAB symptoms when compared with placebo. It is still not clear whether any of the specific drugs that are available in Brazil offer advantages over the others. These drugs are associated with adverse effects (dry mouth and constipation), although they are not related to an increase in the number of withdrawals.Federação Brasileira das Sociedades de Ginecologia e Obstetrícia2016-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016001100564Revista Brasileira de Ginecologia e Obstetrícia v.38 n.11 2016reponame:Revista brasileira de ginecologia e obstetrícia (Online)instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)instacron:FEBRASGO10.1055/s-0036-1594289info:eu-repo/semantics/openAccessFonseca,Andrea Moura Rodrigues Maciel daMeinberg,Mariana FurtadoMonteiro,Marilene Vale de CastroRoque,MatheusHaddad,Jorge MilhenCastro,Rodrigo Aquinoeng2017-02-02T00:00:00Zoai:scielo:S0100-72032016001100564Revistahttp://www.scielo.br/rbgohttps://old.scielo.br/oai/scielo-oai.phppublicações@febrasgo.org.br||rbgo@fmrp.usp.br1806-93390100-7203opendoar:2017-02-02T00:00Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)false |
dc.title.none.fl_str_mv |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
title |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
spellingShingle |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis Fonseca,Andrea Moura Rodrigues Maciel da overactive bladder urge incontinence urinary frequency and antimuscarinics |
title_short |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
title_full |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
title_fullStr |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
title_full_unstemmed |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
title_sort |
The Effectiveness of Anticholinergic Therapy for Overactive Bladders: Systematic Review and Meta-Analysis |
author |
Fonseca,Andrea Moura Rodrigues Maciel da |
author_facet |
Fonseca,Andrea Moura Rodrigues Maciel da Meinberg,Mariana Furtado Monteiro,Marilene Vale de Castro Roque,Matheus Haddad,Jorge Milhen Castro,Rodrigo Aquino |
author_role |
author |
author2 |
Meinberg,Mariana Furtado Monteiro,Marilene Vale de Castro Roque,Matheus Haddad,Jorge Milhen Castro,Rodrigo Aquino |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Fonseca,Andrea Moura Rodrigues Maciel da Meinberg,Mariana Furtado Monteiro,Marilene Vale de Castro Roque,Matheus Haddad,Jorge Milhen Castro,Rodrigo Aquino |
dc.subject.por.fl_str_mv |
overactive bladder urge incontinence urinary frequency and antimuscarinics |
topic |
overactive bladder urge incontinence urinary frequency and antimuscarinics |
description |
Abstract The overactive bladder (OAB) has a significant negative impact on the quality of life of patients. Antimuscarinics have become the pharmacological treatment of choice for this condition. The objective of this systematic review and meta-analysis is to examine the evidence from randomized clinical trials about the outcomes of the antimuscarinic drugs available in Brazil on OABs. We searched MEDLINE and the Cochrane Central Register of Controlled Trials from the inception of these databases through to September 2015. The primary outcome measures were the mean decrease in urge urinary incontinence episodes and the mean decrease in the frequency of micturition. The results suggest that there is a moderate to high amount of evidence supporting the benefit of using anticholinergic drugs in alleviating OAB symptoms when compared with placebo. It is still not clear whether any of the specific drugs that are available in Brazil offer advantages over the others. These drugs are associated with adverse effects (dry mouth and constipation), although they are not related to an increase in the number of withdrawals. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016001100564 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016001100564 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1055/s-0036-1594289 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
publisher.none.fl_str_mv |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ginecologia e Obstetrícia v.38 n.11 2016 reponame:Revista brasileira de ginecologia e obstetrícia (Online) instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO |
instname_str |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) |
instacron_str |
FEBRASGO |
institution |
FEBRASGO |
reponame_str |
Revista brasileira de ginecologia e obstetrícia (Online) |
collection |
Revista brasileira de ginecologia e obstetrícia (Online) |
repository.name.fl_str_mv |
Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) |
repository.mail.fl_str_mv |
publicações@febrasgo.org.br||rbgo@fmrp.usp.br |
_version_ |
1754115943570604032 |