Diagnosis, classification and treatment of gestational trophoblastic neoplasia

Detalhes bibliográficos
Autor(a) principal: Biscaro,Andressa
Data de Publicação: 2015
Outros Autores: Braga,Antônio, Berkowitz,Ross Stuart
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de ginecologia e obstetrícia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032015000100042
Resumo: Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.
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spelling Diagnosis, classification and treatment of gestational trophoblastic neoplasiaGestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.Federação Brasileira das Sociedades de Ginecologia e Obstetrícia2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032015000100042Revista Brasileira de Ginecologia e Obstetrícia v.37 n.1 2015reponame:Revista brasileira de ginecologia e obstetrícia (Online)instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)instacron:FEBRASGO10.1590/SO100-720320140005198info:eu-repo/semantics/openAccessBiscaro,AndressaBraga,AntônioBerkowitz,Ross Stuarteng2015-09-10T00:00:00Zoai:scielo:S0100-72032015000100042Revistahttp://www.scielo.br/rbgohttps://old.scielo.br/oai/scielo-oai.phppublicações@febrasgo.org.br||rbgo@fmrp.usp.br1806-93390100-7203opendoar:2015-09-10T00:00Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)false
dc.title.none.fl_str_mv Diagnosis, classification and treatment of gestational trophoblastic neoplasia
title Diagnosis, classification and treatment of gestational trophoblastic neoplasia
spellingShingle Diagnosis, classification and treatment of gestational trophoblastic neoplasia
Biscaro,Andressa
title_short Diagnosis, classification and treatment of gestational trophoblastic neoplasia
title_full Diagnosis, classification and treatment of gestational trophoblastic neoplasia
title_fullStr Diagnosis, classification and treatment of gestational trophoblastic neoplasia
title_full_unstemmed Diagnosis, classification and treatment of gestational trophoblastic neoplasia
title_sort Diagnosis, classification and treatment of gestational trophoblastic neoplasia
author Biscaro,Andressa
author_facet Biscaro,Andressa
Braga,Antônio
Berkowitz,Ross Stuart
author_role author
author2 Braga,Antônio
Berkowitz,Ross Stuart
author2_role author
author
dc.contributor.author.fl_str_mv Biscaro,Andressa
Braga,Antônio
Berkowitz,Ross Stuart
description Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032015000100042
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/SO100-720320140005198
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dc.publisher.none.fl_str_mv Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
publisher.none.fl_str_mv Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
dc.source.none.fl_str_mv Revista Brasileira de Ginecologia e Obstetrícia v.37 n.1 2015
reponame:Revista brasileira de ginecologia e obstetrícia (Online)
instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)
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reponame_str Revista brasileira de ginecologia e obstetrícia (Online)
collection Revista brasileira de ginecologia e obstetrícia (Online)
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repository.mail.fl_str_mv publicações@febrasgo.org.br||rbgo@fmrp.usp.br
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