Antinociceptive activity of essential oil from Echinodorus macrophyllus(Kunth.)Micheli (Alismataceae)

• Autor(a) principal: Coelho, Marsen G. P.
• Data de Publicação: 2012
• Outros Autores: Velozo, Leosvaldo S. M., Fernandes, Daniele C., Alves, Rafael A., Siqueira, Helena A. A., Silva, Girlaine P., Santos, Shirley V. M., Gayer, Carlos R. M.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/163
• topic: Echinodorus macrophyllus; essential oil; hydrodistillation; antinociceptive potential; Echinodorus macrophyllus; óleo essencial; hidrodestilação; potencial antinociceptivo

Echinodorus macrophyllus (Kunth.) Mich. is a plant of aquatic habits popularly known in Brazil as "chapéu de couro", being used for the treatment of rheumatism and other infammatory diseases, as a diuretic and antisyphilitic. The aim of this study was to evaluate the antinociceptive effects of essential oil of Echinodorus macrophyllus (EOEm), obtained through hydrodistillation for two hours, in Clevenger-type modified apparatus. The EOEm chromatographic profile analyses on gas chromatography coupled to mass spectrometry (GC-MS) allowed the identification of 21 components which three are majority (dillapiole, 2-tridecanone and caryophyllene oxide). The evaluation of the antinociceptive activity of EOEm, was done using the hyperalgesia model induced by intraperitoneal (i.p.) injection of acetic acid. Swiss Webster (SW) male mice were orally (p.o.) treated with EOEm with 50 and 100 mg/kg EOEm doses (p.o.), showed significant inhibition of acetic acid-induced contortions by 65% and 59% respectively, compared with the control group. This activity possibly is related to the inhibition of nociception-specific receptors, thereby, analgesia.