Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations

Detalhes bibliográficos
Autor(a) principal: Marreto, R. N.
Data de Publicação: 2007
Outros Autores: Ferdeman Neto, A., Pereira, N.L., Santana, D. P., Ramos, M. F. S.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70
Resumo: The aim of the present work was to evaluate the influence of the light and oxygen on the phenolic constituents of fluid and solid Schinus terebinthifolius intermediated preparations. The fluid extract was obtained through official procedure and incorporated into cellulose granules by wet granulation. The granules were coating by a fluidization technique using polyvinyl acetate phthalate, as wall material. The different preparations obtained were submitted to drastic conditions of artificial light exposure and oxygen concentration and its chemical stability was evaluated by total phenolic content analysis and scanning UV spectra. The results showed that light influence depends of the physical state and concentration of the preparations. On the other hand, the oxygen influence do not depend of these factors and can not be controlled even by the biggest weight gain coating operation, that is functional, from the point of view of phenolic releasing.
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spelling Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated PreparationsAvaliação da Estabilidade Química de Preparações Intermediárias de Schinus terebinthifolius Raddi (Aroeira da Praia)Phenol OxidationEnteric CoatingGranulationPhotochemical ProcessOxidação de FenóisRevestimento pH-DependenteGranulaçãoProcesso FotoquímicoThe aim of the present work was to evaluate the influence of the light and oxygen on the phenolic constituents of fluid and solid Schinus terebinthifolius intermediated preparations. The fluid extract was obtained through official procedure and incorporated into cellulose granules by wet granulation. The granules were coating by a fluidization technique using polyvinyl acetate phthalate, as wall material. The different preparations obtained were submitted to drastic conditions of artificial light exposure and oxygen concentration and its chemical stability was evaluated by total phenolic content analysis and scanning UV spectra. The results showed that light influence depends of the physical state and concentration of the preparations. On the other hand, the oxygen influence do not depend of these factors and can not be controlled even by the biggest weight gain coating operation, that is functional, from the point of view of phenolic releasing.O objetivo deste trabalho foi avaliar a influência da energia luminosa e do oxigênio sobre a estabilidade química de constituintes fenólicos do extrato fluido da aroeira da praia (Schinus terebinthifolius Raddi) e de preparações tecnologicamente desenvolvidas a partir deste. O extrato fluido foi obtido por percolação simples, segundo monografia farmacopêica, e incorporado em grânulos de celulose posteriormente revestidos, por leito fluidizado, com acetoftalato de polivinila. Os diferentes materiais foram ensaiados sob condições drásticas de irradiação luminosa artificial e expostos à atmosfera rica em oxigênio. O teor de fenóis totais e o perfil de absorção no ultravioleta foram empregados na avaliação da integridade química tanto do extrato fluido quanto das preparações secas. Os resultados demonstraram que o impacto da energia luminosa sobre a composição fenólica dos extratos depende da concentração e do estado físico dos mesmos. Por outro lado, a ação do oxigênio independe desses fatores e não pôde ser controlada nem mesmo pela aplicação de revestimento com ganho de massa de até 30 %. Ensaios de liberação foram realizados para avaliar a funcionalidade da membrana polimérica. Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2007-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/7010.32712/2446-4775.2007.70Revista Fitos; Vol. 3 No. 01 (2007); 85-92Revista Fitos; Vol. 3 Núm. 01 (2007); 85-92Revista Fitos; v. 3 n. 01 (2007); 85-922446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70/69https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70/1255Copyright (c) 2007 Revista Fitos Eletrônicahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMarreto, R. N.Ferdeman Neto, A.Pereira, N.L.Santana, D. P.Ramos, M. F. S.2022-10-24T17:38:49Zoai:ojs.revistafitos.far.fiocruz.br:article/70Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-10-24T17:38:49Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
Avaliação da Estabilidade Química de Preparações Intermediárias de Schinus terebinthifolius Raddi (Aroeira da Praia)
title Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
spellingShingle Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
Marreto, R. N.
Phenol Oxidation
Enteric Coating
Granulation
Photochemical Process
Oxidação de Fenóis
Revestimento pH-Dependente
Granulação
Processo Fotoquímico
title_short Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
title_full Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
title_fullStr Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
title_full_unstemmed Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
title_sort Investigation of the Chemical Stability of Some Schinus terebinthifolius Raddi Intermediated Preparations
author Marreto, R. N.
author_facet Marreto, R. N.
Ferdeman Neto, A.
Pereira, N.L.
Santana, D. P.
Ramos, M. F. S.
author_role author
author2 Ferdeman Neto, A.
Pereira, N.L.
Santana, D. P.
Ramos, M. F. S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Marreto, R. N.
Ferdeman Neto, A.
Pereira, N.L.
Santana, D. P.
Ramos, M. F. S.
dc.subject.por.fl_str_mv Phenol Oxidation
Enteric Coating
Granulation
Photochemical Process
Oxidação de Fenóis
Revestimento pH-Dependente
Granulação
Processo Fotoquímico
topic Phenol Oxidation
Enteric Coating
Granulation
Photochemical Process
Oxidação de Fenóis
Revestimento pH-Dependente
Granulação
Processo Fotoquímico
description The aim of the present work was to evaluate the influence of the light and oxygen on the phenolic constituents of fluid and solid Schinus terebinthifolius intermediated preparations. The fluid extract was obtained through official procedure and incorporated into cellulose granules by wet granulation. The granules were coating by a fluidization technique using polyvinyl acetate phthalate, as wall material. The different preparations obtained were submitted to drastic conditions of artificial light exposure and oxygen concentration and its chemical stability was evaluated by total phenolic content analysis and scanning UV spectra. The results showed that light influence depends of the physical state and concentration of the preparations. On the other hand, the oxygen influence do not depend of these factors and can not be controlled even by the biggest weight gain coating operation, that is functional, from the point of view of phenolic releasing.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70
10.32712/2446-4775.2007.70
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70
identifier_str_mv 10.32712/2446-4775.2007.70
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70/69
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/70/1255
dc.rights.driver.fl_str_mv Copyright (c) 2007 Revista Fitos Eletrônica
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2007 Revista Fitos Eletrônica
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 3 No. 01 (2007); 85-92
Revista Fitos; Vol. 3 Núm. 01 (2007); 85-92
Revista Fitos; v. 3 n. 01 (2007); 85-92
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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