Drug interaction between standardized herbal medicines by the Unified Health System and conventional medicines

• Autor(a) principal: Rubio, Karina Taciana Santos
• Data de Publicação: 2022
• Outros Autores: Nascimento, Maria Alice Pereira do, Martucci, Maria Elvira Poleti
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1138
• topic: Phytotherapics; Phytotherapy; Adverse events; Drug interactions; Medicinal plants; Unified Health System; Fitoterápicos; Fitoterapia; Eventos adversos; Interações medicamentosas; Plantas Medicinais; Sistema Único de Saúde

Medicinal plants and phytotherapics are considered an alternative for the treatment of several diseases. The SUS has 12 phytotherapics standardized in the RENAME: artichoke, mastic, aloe vera, holy cashew, espinheira-santa, devil's claw, guaco, mint, soy isoflavone, plantago, willow and unha-de-gato. The aim of this work was to evaluate the adverse events of these phytotherapics and the possible drug interactions resulting from the use of conventional medicines concomitant with the use of these phytotherapics. The work was carried out through a review of the databases between 1995 and 2020. Medicinal plants and phytotherapics are constituted of chemical compounds, which are mostly responsible for their pharmacological actions. The complexity of these substances increases the possibility of interactions occurring when conventional drugs are used concomitantly. The interactions can be beneficial or unfavorable, since they can increase drug's effect, reduce its effectiveness, result in adverse reactions or not cause changes in the expected effect of the drug. This work emphasizes the importance of considering herbal medicines and phytotherapics with the same importance as synthetic medicines, basing clinical conduct on reliable scientific evidence, recognizing its effectiveness, but also its adverse effects and the possibility of drug interactions making, thus, its use safer and more efficient.