The impact of bioprospecting for the discovery of new drugs

• Autor(a) principal: Marques, Lana Grasiela Alves
• Data de Publicação: 2022
• Outros Autores: Vieira Neto, Jose de Brito, Sales, Sarah Leyenne Alves, Costa, Pedro Mikael da Silva, Guimarães, Celina de Jesus, Manso, Mariana Palmeira, Pereira, João Victor de Melo, Pessoa, Claudia do Ó
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1313
• topic: Anticâncer; Screening; Biodiversidade; Bioativos; Bioprospecção; Anticancer; Screening; Biodiversity; Bioactive; Bioprospecting

The use of natural products in the development of new drugs has been widely discussed in the last 50 years. In this sense, the biodiversity of several countries significantly influences the discovery of new bioactive molecules, such as the chemotherapeutic agents of natural origin vinblastine and Taxol. Bioprospecting, which refers to the collection of new plant species to be tested in screening models and subsequently in analytical techniques, generates several molecules whose activities may configure potential biological actions in the treatment of different diseases, such as cancer. Under this perspective, the present work aims to relate the screening models High Content Screening, High Throughput Screening and Virtual Screening, in the discovery of new molecules. In addition, comparatively analyzing institutions, legislations and financial investments in the study and development of natural’s products according to their biodiversity. It was concluded that, although there are efforts for the use of biodiversity in the advancement of science, they still have several difficulties, especially Brazil, which has not presented an expressive program or contract in bioprospecting as the other nations mentioned.