Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease

Detalhes bibliográficos
Autor(a) principal: Winnie Ramos da Silva, Ayla
Data de Publicação: 2020
Outros Autores: Biegelmeyer, Renata
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909
Resumo: Alzheimer's disease (AD) is a neurodegenerative disorder that causes brain atrophy, leading to dementia in elderly. Considering that there is no known cure, the available drug treatments are related to alleviate the symptoms. Among the alternative treatments, Curcuma longa L. showed anti-inflammatory and antioxidant properties, important for the process of AD progression. Despite its benefits, it has been shown low bioavailability in studies performed. In the present review, we aimed to search the literature for alternatives to improve the bioavailability of C. longa for application in the treatment of Alzheimer's disease. Thus, a bibliographic review was performed in scientific databases, using a clear and inclusive search strategy. 93 articles were found and 32 were selected. Among the alternatives, pharmaceutical formulations showed featured, such as nanoparticles, micelles and emulsions. The pharmacological properties of C. longa and the many possibilities of altering its bioavailability, justify the importance to development of studies directed to use these compounds in AD therapy. Therefore, we hoped that these results may encourage further researches towards the development of C. longa-based phytotherapic and/or phytomedicines for the auxiliary treatment of Alzheimer's disease.
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spelling Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's DiseaseCurcuma longa L. (Zingiberaceae): desenvolvimento tecnológico para aplicação como agente terapêutico auxiliar no tratamento de pacientes portadores da Doença de AlzheimerAlzheimer'sTurmericTreatmentCurcuminNeurodegenerativeBioavailabilityAlzheimerCúrcumaTratamentoCurcuminaNeurodegenerativaBiodisponibilidadeAlzheimer's disease (AD) is a neurodegenerative disorder that causes brain atrophy, leading to dementia in elderly. Considering that there is no known cure, the available drug treatments are related to alleviate the symptoms. Among the alternative treatments, Curcuma longa L. showed anti-inflammatory and antioxidant properties, important for the process of AD progression. Despite its benefits, it has been shown low bioavailability in studies performed. In the present review, we aimed to search the literature for alternatives to improve the bioavailability of C. longa for application in the treatment of Alzheimer's disease. Thus, a bibliographic review was performed in scientific databases, using a clear and inclusive search strategy. 93 articles were found and 32 were selected. Among the alternatives, pharmaceutical formulations showed featured, such as nanoparticles, micelles and emulsions. The pharmacological properties of C. longa and the many possibilities of altering its bioavailability, justify the importance to development of studies directed to use these compounds in AD therapy. Therefore, we hoped that these results may encourage further researches towards the development of C. longa-based phytotherapic and/or phytomedicines for the auxiliary treatment of Alzheimer's disease.A Doença de Alzheimer (DA) é uma enfermidade neurodegenerativa que provoca atrofia no cérebro, levando à demência em idosos; por não haver cura conhecida, os tratamentos medicamentosos disponíveis são relacionados a amenizar os sintomas. Entre os tratamentos alternativos, a Curcuma longa L. demonstrou propriedades anti-inflamatórias e antioxidantes, importantes para o processo de progressão da DA. Em contrapartida aos seus muitos benefícios, apresentou baixa biodisponibilidade nos estudos realizados. Na presente revisão objetivou-se buscar, na literatura, alternativas para melhorar a biodisponibilidade de C. longa para aplicação no tratamento da DA. Desta forma, foi realizada revisão bibliográfica em bases de dados científicas, utilizando estratégia de busca clara e inclusiva. Foram encontrados 93 artigos e, destes, selecionados 32. Dentre as alternativas encontradas, as formulações farmacêuticas ganharam destaque, com exemplos como nanopartículas, micelas e emulsões. As propriedades farmacológicas de C. longa e as muitas possibilidades de alterar sua biodisponibilidade justificam atribuir importância ao desenvolvimento de estudos direcionados ao uso destes compostos na terapia da DA. Portanto, espera-se que estes resultados possam incentivar o aprofundamento de pesquisas no sentido de desenvolvimento de fitoterápicos e/ou fitofármacos com base em C. longa e seus metabólitos para o tratamento auxiliar da doença de Alzheimer.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2020-08-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/90910.32712/2446-4775.2020.909Revista Fitos; Vol. 14 No. 2 (2020); 249-258Revista Fitos; Vol. 14 Núm. 2 (2020); 249-258Revista Fitos; v. 14 n. 2 (2020); 249-2582446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909/698https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909/699Copyright (c) 2020 Revista Fitoshttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessWinnie Ramos da Silva, AylaBiegelmeyer, Renata2020-09-30T14:59:12Zoai:ojs.revistafitos.far.fiocruz.br:article/909Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2020-09-30T14:59:12Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
Curcuma longa L. (Zingiberaceae): desenvolvimento tecnológico para aplicação como agente terapêutico auxiliar no tratamento de pacientes portadores da Doença de Alzheimer
title Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
spellingShingle Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
Winnie Ramos da Silva, Ayla
Alzheimer's
Turmeric
Treatment
Curcumin
Neurodegenerative
Bioavailability
Alzheimer
Cúrcuma
Tratamento
Curcumina
Neurodegenerativa
Biodisponibilidade
title_short Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
title_full Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
title_fullStr Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
title_full_unstemmed Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
title_sort Curcuma longa L. (Zingiberaceae): technological development for application as an auxiliary therapeutic agent in the treatment of patients with Alzheimer's Disease
author Winnie Ramos da Silva, Ayla
author_facet Winnie Ramos da Silva, Ayla
Biegelmeyer, Renata
author_role author
author2 Biegelmeyer, Renata
author2_role author
dc.contributor.author.fl_str_mv Winnie Ramos da Silva, Ayla
Biegelmeyer, Renata
dc.subject.por.fl_str_mv Alzheimer's
Turmeric
Treatment
Curcumin
Neurodegenerative
Bioavailability
Alzheimer
Cúrcuma
Tratamento
Curcumina
Neurodegenerativa
Biodisponibilidade
topic Alzheimer's
Turmeric
Treatment
Curcumin
Neurodegenerative
Bioavailability
Alzheimer
Cúrcuma
Tratamento
Curcumina
Neurodegenerativa
Biodisponibilidade
description Alzheimer's disease (AD) is a neurodegenerative disorder that causes brain atrophy, leading to dementia in elderly. Considering that there is no known cure, the available drug treatments are related to alleviate the symptoms. Among the alternative treatments, Curcuma longa L. showed anti-inflammatory and antioxidant properties, important for the process of AD progression. Despite its benefits, it has been shown low bioavailability in studies performed. In the present review, we aimed to search the literature for alternatives to improve the bioavailability of C. longa for application in the treatment of Alzheimer's disease. Thus, a bibliographic review was performed in scientific databases, using a clear and inclusive search strategy. 93 articles were found and 32 were selected. Among the alternatives, pharmaceutical formulations showed featured, such as nanoparticles, micelles and emulsions. The pharmacological properties of C. longa and the many possibilities of altering its bioavailability, justify the importance to development of studies directed to use these compounds in AD therapy. Therefore, we hoped that these results may encourage further researches towards the development of C. longa-based phytotherapic and/or phytomedicines for the auxiliary treatment of Alzheimer's disease.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909
10.32712/2446-4775.2020.909
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909
identifier_str_mv 10.32712/2446-4775.2020.909
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909/698
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/909/699
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Fitos
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Fitos
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 14 No. 2 (2020); 249-258
Revista Fitos; Vol. 14 Núm. 2 (2020); 249-258
Revista Fitos; v. 14 n. 2 (2020); 249-258
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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