Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing

Detalhes bibliográficos
Autor(a) principal: Danilevicz, Chris Krebs
Data de Publicação: 2020
Outros Autores: Wagner, Vivian Petersen, Webber, Liana Preto, Schmidt, Tuany Rafaeli, Alonso, Ellen Cristine Pineze, Mendonca, Elismauro Francisco de, Valadares, Marize Campos, Marreto, Ricardo Neves, Martins, Manoela Domingues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/229986
Resumo: Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.
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spelling Danilevicz, Chris KrebsWagner, Vivian PetersenWebber, Liana PretoSchmidt, Tuany RafaeliAlonso, Ellen Cristine PinezeMendonca, Elismauro Francisco deValadares, Marize CamposMarreto, Ricardo NevesMartins, Manoela Domingues2021-09-22T04:23:29Z20202357-9730http://hdl.handle.net/10183/229986001131411Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 40, no. 2 (2020), p. 117-124.Úlceras oraisCúrcumaFitoterapiaCurcuminTurmeric extractCurcuminoidPhytotherapyPhytomedicineEffects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001131411.pdf.txt001131411.pdf.txtExtracted Texttext/plain32483http://www.lume.ufrgs.br/bitstream/10183/229986/2/001131411.pdf.txt9a11b27ef0c9de4e2da20f3679a64084MD52ORIGINAL001131411.pdfTexto completo (inglês)application/pdf1826325http://www.lume.ufrgs.br/bitstream/10183/229986/1/001131411.pdf03e2624cda9446d4c4a13fe46223814eMD5110183/2299862021-10-04 04:22:09.622496oai:www.lume.ufrgs.br:10183/229986Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-10-04T07:22:09Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
title Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
spellingShingle Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
Danilevicz, Chris Krebs
Úlceras orais
Cúrcuma
Fitoterapia
Curcumin
Turmeric extract
Curcuminoid
Phytotherapy
Phytomedicine
title_short Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
title_full Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
title_fullStr Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
title_full_unstemmed Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
title_sort Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
author Danilevicz, Chris Krebs
author_facet Danilevicz, Chris Krebs
Wagner, Vivian Petersen
Webber, Liana Preto
Schmidt, Tuany Rafaeli
Alonso, Ellen Cristine Pineze
Mendonca, Elismauro Francisco de
Valadares, Marize Campos
Marreto, Ricardo Neves
Martins, Manoela Domingues
author_role author
author2 Wagner, Vivian Petersen
Webber, Liana Preto
Schmidt, Tuany Rafaeli
Alonso, Ellen Cristine Pineze
Mendonca, Elismauro Francisco de
Valadares, Marize Campos
Marreto, Ricardo Neves
Martins, Manoela Domingues
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Danilevicz, Chris Krebs
Wagner, Vivian Petersen
Webber, Liana Preto
Schmidt, Tuany Rafaeli
Alonso, Ellen Cristine Pineze
Mendonca, Elismauro Francisco de
Valadares, Marize Campos
Marreto, Ricardo Neves
Martins, Manoela Domingues
dc.subject.por.fl_str_mv Úlceras orais
Cúrcuma
Fitoterapia
topic Úlceras orais
Cúrcuma
Fitoterapia
Curcumin
Turmeric extract
Curcuminoid
Phytotherapy
Phytomedicine
dc.subject.eng.fl_str_mv Curcumin
Turmeric extract
Curcuminoid
Phytotherapy
Phytomedicine
description Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-09-22T04:23:29Z
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dc.relation.ispartof.pt_BR.fl_str_mv Clinical and biomedical research. Porto Alegre. Vol. 40, no. 2 (2020), p. 117-124.
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