Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/229986 |
Resumo: | Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation. |
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Danilevicz, Chris KrebsWagner, Vivian PetersenWebber, Liana PretoSchmidt, Tuany RafaeliAlonso, Ellen Cristine PinezeMendonca, Elismauro Francisco deValadares, Marize CamposMarreto, Ricardo NevesMartins, Manoela Domingues2021-09-22T04:23:29Z20202357-9730http://hdl.handle.net/10183/229986001131411Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 40, no. 2 (2020), p. 117-124.Úlceras oraisCúrcumaFitoterapiaCurcuminTurmeric extractCurcuminoidPhytotherapyPhytomedicineEffects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001131411.pdf.txt001131411.pdf.txtExtracted Texttext/plain32483http://www.lume.ufrgs.br/bitstream/10183/229986/2/001131411.pdf.txt9a11b27ef0c9de4e2da20f3679a64084MD52ORIGINAL001131411.pdfTexto completo (inglês)application/pdf1826325http://www.lume.ufrgs.br/bitstream/10183/229986/1/001131411.pdf03e2624cda9446d4c4a13fe46223814eMD5110183/2299862021-10-04 04:22:09.622496oai:www.lume.ufrgs.br:10183/229986Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-10-04T07:22:09Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
title |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
spellingShingle |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing Danilevicz, Chris Krebs Úlceras orais Cúrcuma Fitoterapia Curcumin Turmeric extract Curcuminoid Phytotherapy Phytomedicine |
title_short |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
title_full |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
title_fullStr |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
title_full_unstemmed |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
title_sort |
Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing |
author |
Danilevicz, Chris Krebs |
author_facet |
Danilevicz, Chris Krebs Wagner, Vivian Petersen Webber, Liana Preto Schmidt, Tuany Rafaeli Alonso, Ellen Cristine Pineze Mendonca, Elismauro Francisco de Valadares, Marize Campos Marreto, Ricardo Neves Martins, Manoela Domingues |
author_role |
author |
author2 |
Wagner, Vivian Petersen Webber, Liana Preto Schmidt, Tuany Rafaeli Alonso, Ellen Cristine Pineze Mendonca, Elismauro Francisco de Valadares, Marize Campos Marreto, Ricardo Neves Martins, Manoela Domingues |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Danilevicz, Chris Krebs Wagner, Vivian Petersen Webber, Liana Preto Schmidt, Tuany Rafaeli Alonso, Ellen Cristine Pineze Mendonca, Elismauro Francisco de Valadares, Marize Campos Marreto, Ricardo Neves Martins, Manoela Domingues |
dc.subject.por.fl_str_mv |
Úlceras orais Cúrcuma Fitoterapia |
topic |
Úlceras orais Cúrcuma Fitoterapia Curcumin Turmeric extract Curcuminoid Phytotherapy Phytomedicine |
dc.subject.eng.fl_str_mv |
Curcumin Turmeric extract Curcuminoid Phytotherapy Phytomedicine |
description |
Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-09-22T04:23:29Z |
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http://hdl.handle.net/10183/229986 |
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2357-9730 |
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001131411 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Clinical and biomedical research. Porto Alegre. Vol. 40, no. 2 (2020), p. 117-124. |
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