Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil

Detalhes bibliográficos
Autor(a) principal: Silva, Emily Thalia Teixeira da
Data de Publicação: 2023
Outros Autores: Almeida Junior, Luiz Domingues de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306
Resumo: Cannabis sativa L. (Cannabaceae) has been used by humans for thousands of years, being a plant currently widely studied in drug development and its medicinal use in natura has been widely discussed, given its pharmacological potential. This manuscript describes the pharmacological aspects and legislation associated with Cannabis sativa L. in Brazil through a literature review in indexed databases and regulatory agencies. Cannabis sativa L. has a wide variety of chemicals, such as delta-9-tetrahydrocannabinol, cannabidiol, cannabigerol, cannabinol and delta-8-tetrahydrocannabinol as the most studied. The human organism has a series of cannabinoid receptors and the modulation of these receptors is associated with the medicinal use of the species. In Brazil, the use of Cannabis sativa L. has gone through numerous legal stages. From criminalization in 1932 to the authorization of cannabinoid-containing drugs in 2019. In the technological and scientific context there is a constant search to elucidate the potential of the plant, but these factors confront legal and social aspects.
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spelling Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in BrazilUso medicinal da Cannabis sativa L. (Cannabaceae): aspectos biológicos e a legislação no BrasilCannabisCannabis sativa LCanabinoidesLegislação de MedicamentosCannabisCannabis sativa LCannabinoidsDrug legislationCannabis sativa L. (Cannabaceae) has been used by humans for thousands of years, being a plant currently widely studied in drug development and its medicinal use in natura has been widely discussed, given its pharmacological potential. This manuscript describes the pharmacological aspects and legislation associated with Cannabis sativa L. in Brazil through a literature review in indexed databases and regulatory agencies. Cannabis sativa L. has a wide variety of chemicals, such as delta-9-tetrahydrocannabinol, cannabidiol, cannabigerol, cannabinol and delta-8-tetrahydrocannabinol as the most studied. The human organism has a series of cannabinoid receptors and the modulation of these receptors is associated with the medicinal use of the species. In Brazil, the use of Cannabis sativa L. has gone through numerous legal stages. From criminalization in 1932 to the authorization of cannabinoid-containing drugs in 2019. In the technological and scientific context there is a constant search to elucidate the potential of the plant, but these factors confront legal and social aspects.A Cannabis sativa L. (Cannabaceae) é utilizada pelo ser humano a milhares de anos, sendo uma planta, atualmente, muito estudada no desenvolvimento de medicamentos, e o seu uso medicinal in natura têm sido amplamente discutido, dada a sua potencialidade farmacológica. O presente artigo descreveu os aspectos farmacológicos e a legislação associados à Cannabis sativa L. no Brasil através de uma revisão de literatura, feita por meio de consultas em bases de dados indexadas e portais institucionais. Cannabis sativa L. possui uma ampla variedade de substâncias químicas, sendo o delta-9-tetra-hidrocanabinol, canabidiol, canabigerol, canabinol e o delta-8-tetra-hidrocanabinol os mais conhecidos e estudados. O organismo humano apresenta uma série de receptores canabinoides, e a modulação desses receptores está associada ao uso medicinal da planta. No Brasil, a utilização de Cannabis sativa L. e seus derivados passaram por inúmeras fases legais, desde a criminalização, a partir de 1932, até a autorização de medicamentos contendo canabinoides, em 2019. No contexto tecnológico e científico existe uma constante busca por elucidar as potencialidades da planta. Porém, esses fatores confrontam com os aspectos legais e sociais.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2023-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmltext/xmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/130610.32712/2446-4775.2022.1306Revista Fitos; Vol. 17 No. 1 (2023); 89-102Revista Fitos; Vol. 17 Núm. 1 (2023); 89-102Revista Fitos; v. 17 n. 1 (2023); 89-1022446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306/1266https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306/1267https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306/1374Copyright (c) 2022 Revista Fitoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Emily Thalia Teixeira daAlmeida Junior, Luiz Domingues de2023-04-18T13:02:07Zoai:ojs.revistafitos.far.fiocruz.br:article/1306Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2023-04-18T13:02:07Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
Uso medicinal da Cannabis sativa L. (Cannabaceae): aspectos biológicos e a legislação no Brasil
title Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
spellingShingle Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
Silva, Emily Thalia Teixeira da
Cannabis
Cannabis sativa L
Canabinoides
Legislação de Medicamentos
Cannabis
Cannabis sativa L
Cannabinoids
Drug legislation
title_short Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
title_full Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
title_fullStr Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
title_full_unstemmed Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
title_sort Medicinal use of Cannabis sativa L. (Cannabaceae): biological aspects and legislation in Brazil
author Silva, Emily Thalia Teixeira da
author_facet Silva, Emily Thalia Teixeira da
Almeida Junior, Luiz Domingues de
author_role author
author2 Almeida Junior, Luiz Domingues de
author2_role author
dc.contributor.author.fl_str_mv Silva, Emily Thalia Teixeira da
Almeida Junior, Luiz Domingues de
dc.subject.por.fl_str_mv Cannabis
Cannabis sativa L
Canabinoides
Legislação de Medicamentos
Cannabis
Cannabis sativa L
Cannabinoids
Drug legislation
topic Cannabis
Cannabis sativa L
Canabinoides
Legislação de Medicamentos
Cannabis
Cannabis sativa L
Cannabinoids
Drug legislation
description Cannabis sativa L. (Cannabaceae) has been used by humans for thousands of years, being a plant currently widely studied in drug development and its medicinal use in natura has been widely discussed, given its pharmacological potential. This manuscript describes the pharmacological aspects and legislation associated with Cannabis sativa L. in Brazil through a literature review in indexed databases and regulatory agencies. Cannabis sativa L. has a wide variety of chemicals, such as delta-9-tetrahydrocannabinol, cannabidiol, cannabigerol, cannabinol and delta-8-tetrahydrocannabinol as the most studied. The human organism has a series of cannabinoid receptors and the modulation of these receptors is associated with the medicinal use of the species. In Brazil, the use of Cannabis sativa L. has gone through numerous legal stages. From criminalization in 1932 to the authorization of cannabinoid-containing drugs in 2019. In the technological and scientific context there is a constant search to elucidate the potential of the plant, but these factors confront legal and social aspects.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-31
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dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306
10.32712/2446-4775.2022.1306
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306
identifier_str_mv 10.32712/2446-4775.2022.1306
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306/1266
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306/1267
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1306/1374
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Fitos
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Fitos
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
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dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 17 No. 1 (2023); 89-102
Revista Fitos; Vol. 17 Núm. 1 (2023); 89-102
Revista Fitos; v. 17 n. 1 (2023); 89-102
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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