Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Fitos |
Texto Completo: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284 |
Resumo: | Mikania laevigata (Asteraceae) is popularly used in the treatment of respiratory diseases, including asthma, bronchitis, and cough. In Brazil, guaco extracts are used as medicinal products authorized by the National Health Surveillance Agency (ANVISA). In the study, it was evaluated the adaptation and the influence of the seasonal variation of guaco, in a cultivation held in Santarém, state of Pará, Brazil, and a monitoring of coumarin, its primary active constituent. In the growing of guaco, the climate variables, and the coumarin content were evaluated monthly. The coumarin was analyzed by TLC (Thin Layer Chromatography) and quantified by HPLC (High Performance Liquid Chromatography) from hydroalcoholic and aqueous extracts of dried leaves. In the rainy season (january-july), the guaco had a homogeneous growth. In the dry season (august to november), there was loss of plants grown in full sun. The coumarin content was detected throughout the development of the plant, with levels that varied from 0.470 ± 0.01% to 0.886 ± 0.063%. The time of collection does not influenced in the coumarin content of the plants grown with 50% shade, having the mean of 0.712% in the hydroalcoholic extract and 0.744% in the aqueous extract. Based on the results, in partial shade conditions, it was ensured that small farmers could replicate the cultivation of guaco in the Lower Amazon River, in their local productive arrangements of medicinal plants. |
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Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituentGuaco. Coumarin. Pharmaceutical extracts. Amazon. Local productive arrangements of medicinal plants.Mikania laevigata (Asteraceae) is popularly used in the treatment of respiratory diseases, including asthma, bronchitis, and cough. In Brazil, guaco extracts are used as medicinal products authorized by the National Health Surveillance Agency (ANVISA). In the study, it was evaluated the adaptation and the influence of the seasonal variation of guaco, in a cultivation held in Santarém, state of Pará, Brazil, and a monitoring of coumarin, its primary active constituent. In the growing of guaco, the climate variables, and the coumarin content were evaluated monthly. The coumarin was analyzed by TLC (Thin Layer Chromatography) and quantified by HPLC (High Performance Liquid Chromatography) from hydroalcoholic and aqueous extracts of dried leaves. In the rainy season (january-july), the guaco had a homogeneous growth. In the dry season (august to november), there was loss of plants grown in full sun. The coumarin content was detected throughout the development of the plant, with levels that varied from 0.470 ± 0.01% to 0.886 ± 0.063%. The time of collection does not influenced in the coumarin content of the plants grown with 50% shade, having the mean of 0.712% in the hydroalcoholic extract and 0.744% in the aqueous extract. Based on the results, in partial shade conditions, it was ensured that small farmers could replicate the cultivation of guaco in the Lower Amazon River, in their local productive arrangements of medicinal plants.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2017-02-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/28410.5935/2446-4775.20160018Revista Fitos; Vol. 10 No. 3 (2016); 227-237Revista Fitos; Vol. 10 Núm. 3 (2016); 227-237Revista Fitos; v. 10 n. 3 (2016); 227-2372446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284/pdfAlmeida Raposo, Juliana DivinaGalante Neves, FredericoAzevedo de Aguiar, WagnerMagalhães, Pedro MelilloSilva, RodrigoSoares Maia, José GuilhermeVeras Mourão, Rosa Helenainfo:eu-repo/semantics/openAccess2021-01-29T14:20:55Zoai:ojs.revistafitos.far.fiocruz.br:article/284Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2021-01-29T14:20:55Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
title |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
spellingShingle |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent Almeida Raposo, Juliana Divina Guaco. Coumarin. Pharmaceutical extracts. Amazon. Local productive arrangements of medicinal plants. |
title_short |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
title_full |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
title_fullStr |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
title_full_unstemmed |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
title_sort |
Cultivation of Guaco (Mikania laevigata Sch. Bip. ex Baker) in the Lower Amazon River and monitoring of coumarin, its principal active constituent |
author |
Almeida Raposo, Juliana Divina |
author_facet |
Almeida Raposo, Juliana Divina Galante Neves, Frederico Azevedo de Aguiar, Wagner Magalhães, Pedro Melillo Silva, Rodrigo Soares Maia, José Guilherme Veras Mourão, Rosa Helena |
author_role |
author |
author2 |
Galante Neves, Frederico Azevedo de Aguiar, Wagner Magalhães, Pedro Melillo Silva, Rodrigo Soares Maia, José Guilherme Veras Mourão, Rosa Helena |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Almeida Raposo, Juliana Divina Galante Neves, Frederico Azevedo de Aguiar, Wagner Magalhães, Pedro Melillo Silva, Rodrigo Soares Maia, José Guilherme Veras Mourão, Rosa Helena |
dc.subject.por.fl_str_mv |
Guaco. Coumarin. Pharmaceutical extracts. Amazon. Local productive arrangements of medicinal plants. |
topic |
Guaco. Coumarin. Pharmaceutical extracts. Amazon. Local productive arrangements of medicinal plants. |
description |
Mikania laevigata (Asteraceae) is popularly used in the treatment of respiratory diseases, including asthma, bronchitis, and cough. In Brazil, guaco extracts are used as medicinal products authorized by the National Health Surveillance Agency (ANVISA). In the study, it was evaluated the adaptation and the influence of the seasonal variation of guaco, in a cultivation held in Santarém, state of Pará, Brazil, and a monitoring of coumarin, its primary active constituent. In the growing of guaco, the climate variables, and the coumarin content were evaluated monthly. The coumarin was analyzed by TLC (Thin Layer Chromatography) and quantified by HPLC (High Performance Liquid Chromatography) from hydroalcoholic and aqueous extracts of dried leaves. In the rainy season (january-july), the guaco had a homogeneous growth. In the dry season (august to november), there was loss of plants grown in full sun. The coumarin content was detected throughout the development of the plant, with levels that varied from 0.470 ± 0.01% to 0.886 ± 0.063%. The time of collection does not influenced in the coumarin content of the plants grown with 50% shade, having the mean of 0.712% in the hydroalcoholic extract and 0.744% in the aqueous extract. Based on the results, in partial shade conditions, it was ensured that small farmers could replicate the cultivation of guaco in the Lower Amazon River, in their local productive arrangements of medicinal plants. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284 10.5935/2446-4775.20160018 |
url |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284 |
identifier_str_mv |
10.5935/2446-4775.20160018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284/html https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/284/pdf |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
dc.source.none.fl_str_mv |
Revista Fitos; Vol. 10 No. 3 (2016); 227-237 Revista Fitos; Vol. 10 Núm. 3 (2016); 227-237 Revista Fitos; v. 10 n. 3 (2016); 227-237 2446-4775 1808-9569 reponame:Revista Fitos instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Revista Fitos |
collection |
Revista Fitos |
repository.name.fl_str_mv |
Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br |
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