Natural Products Active in Leishmaiasis

Detalhes bibliográficos
Autor(a) principal: Gilbert, B.
Data de Publicação: 2005
Outros Autores: Favoreto, R.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6
Resumo: A surprising variety of natural substances inhibit the experimental growth of Leishmania parasites, which are responsible for the three main forms of the disease leishmaniasis - cutaneous, muco-cutaneous and visceral. Results obtained with plant extracts, sometimes in vivo, although more frequently in vitro, demonstrate that the activity can be found in a wide variety of botanical families. Notable examples include Crassulaceae (genus Kalanchoe), Annonaceae (many genera). Piperaceae (especially Piper spp), Rutaceae (notably the genus Galipea) and Apocynaceae (genus Peschiera among others). Chemical classes that are important include alkaloids and chalcones that act directly on the parasite, while other classes embrace a variety of substances - phenolics, terpenoids, including di- and triterpenoids, and polysaccharides, whose action is often on the macrophage, host cell to the parasite, stimulating it to produce nitric oxide, mediators such as TNFa and INFs or other factors of the immune system lethal to Leishmania without being harmful to the macrophage itself. The results obtained sometimes confirm traditional uses of the plants and together form a solid basis for the development of new drugs to treat this group of diseases.
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spelling Natural Products Active in LeishmaiasisProdutos Naturais Ativos em LeishmaniosephytotherapyLeishmanianitric oxideimmune systemfitoterápicosLeishmaniaóxido nítricofatores imunológicosA surprising variety of natural substances inhibit the experimental growth of Leishmania parasites, which are responsible for the three main forms of the disease leishmaniasis - cutaneous, muco-cutaneous and visceral. Results obtained with plant extracts, sometimes in vivo, although more frequently in vitro, demonstrate that the activity can be found in a wide variety of botanical families. Notable examples include Crassulaceae (genus Kalanchoe), Annonaceae (many genera). Piperaceae (especially Piper spp), Rutaceae (notably the genus Galipea) and Apocynaceae (genus Peschiera among others). Chemical classes that are important include alkaloids and chalcones that act directly on the parasite, while other classes embrace a variety of substances - phenolics, terpenoids, including di- and triterpenoids, and polysaccharides, whose action is often on the macrophage, host cell to the parasite, stimulating it to produce nitric oxide, mediators such as TNFa and INFs or other factors of the immune system lethal to Leishmania without being harmful to the macrophage itself. The results obtained sometimes confirm traditional uses of the plants and together form a solid basis for the development of new drugs to treat this group of diseases.Uma variedade surpreendente de substâncias naturais inibe o crescimento experimental de parasitos do gênero Leishmania responsáveis pelas três principais formas da doença leishmaniose – a tegumentar, a muco-tegumentar e a visceral. Resultados obtidos com extratos de plantas, às vezes in vivo, mais freqüentemente in vitro, demonstram que a atividade pode ser encontrada numa extensa diversidade de familias, das quais se destacam, entre muitas outras, Crassulaceae (gênero Kalanchoe), Annonaceae (muitos gêneros). Piperaceae (especialmente o gênero Piper), Rutaceae (com destaque para o gênero Galipea) e Apocynaceae (gênero Peschiera entre outros). Classes químicas que se distinguem incluem alcalóides e chalconas que foram em alguns casos demonstradas agir diretamente sobre o parasito, enquanto outras classes que abrangem uma variedade de substâncias fenólicas, terpênicas, inclusive di- e triterpenóides, e polissacarídeos, agem, ou parecem agir, sobre o macrófago, célula hospedeira do parasito, estimulando-o a produzir óxido nítrico, mediadores como TNFa e INFs ou outros fatores da reação imunológica letais à Leishmania sem ser prejudiciais ao próprio macrófago. Os resultados, às vezes, confirmam usos tradicionais das plantas e, em conjunto, formam uma base sólida para o desenvolvimento de novos medicamentos para este grupo de doenças.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2005-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/610.32712/2446-4775.2005.6Revista Fitos; Vol. 1 No. 01 (2005); 43-51Revista Fitos; Vol. 1 Núm. 01 (2005); 43-51Revista Fitos; v. 1 n. 01 (2005); 43-512446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6/pdf_5https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6/1313Copyright (c) 2005 Revista Fitos Eletrônicahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGilbert, B.Favoreto, R.2022-11-07T15:02:06Zoai:ojs.revistafitos.far.fiocruz.br:article/6Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-11-07T15:02:06Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Natural Products Active in Leishmaiasis
Produtos Naturais Ativos em Leishmaniose
title Natural Products Active in Leishmaiasis
spellingShingle Natural Products Active in Leishmaiasis
Gilbert, B.
phytotherapy
Leishmania
nitric oxide
immune system
fitoterápicos
Leishmania
óxido nítrico
fatores imunológicos
title_short Natural Products Active in Leishmaiasis
title_full Natural Products Active in Leishmaiasis
title_fullStr Natural Products Active in Leishmaiasis
title_full_unstemmed Natural Products Active in Leishmaiasis
title_sort Natural Products Active in Leishmaiasis
author Gilbert, B.
author_facet Gilbert, B.
Favoreto, R.
author_role author
author2 Favoreto, R.
author2_role author
dc.contributor.author.fl_str_mv Gilbert, B.
Favoreto, R.
dc.subject.por.fl_str_mv phytotherapy
Leishmania
nitric oxide
immune system
fitoterápicos
Leishmania
óxido nítrico
fatores imunológicos
topic phytotherapy
Leishmania
nitric oxide
immune system
fitoterápicos
Leishmania
óxido nítrico
fatores imunológicos
description A surprising variety of natural substances inhibit the experimental growth of Leishmania parasites, which are responsible for the three main forms of the disease leishmaniasis - cutaneous, muco-cutaneous and visceral. Results obtained with plant extracts, sometimes in vivo, although more frequently in vitro, demonstrate that the activity can be found in a wide variety of botanical families. Notable examples include Crassulaceae (genus Kalanchoe), Annonaceae (many genera). Piperaceae (especially Piper spp), Rutaceae (notably the genus Galipea) and Apocynaceae (genus Peschiera among others). Chemical classes that are important include alkaloids and chalcones that act directly on the parasite, while other classes embrace a variety of substances - phenolics, terpenoids, including di- and triterpenoids, and polysaccharides, whose action is often on the macrophage, host cell to the parasite, stimulating it to produce nitric oxide, mediators such as TNFa and INFs or other factors of the immune system lethal to Leishmania without being harmful to the macrophage itself. The results obtained sometimes confirm traditional uses of the plants and together form a solid basis for the development of new drugs to treat this group of diseases.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-30
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dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6
10.32712/2446-4775.2005.6
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6
identifier_str_mv 10.32712/2446-4775.2005.6
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6/pdf_5
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/6/1313
dc.rights.driver.fl_str_mv Copyright (c) 2005 Revista Fitos Eletrônica
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2005 Revista Fitos Eletrônica
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 1 No. 01 (2005); 43-51
Revista Fitos; Vol. 1 Núm. 01 (2005); 43-51
Revista Fitos; v. 1 n. 01 (2005); 43-51
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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