Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil

Detalhes bibliográficos
Autor(a) principal: Castello-Branco,Luiz RR
Data de Publicação: 2000
Outros Autores: Ortigão-de-Sampaio,Maria Beatriz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700028
Resumo: Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.
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spelling Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazilgastrointestinal immunologyhuman immunodeficiency virus-1 infectionnutritionmucosal immunologyMucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.Instituto Oswaldo Cruz, Ministério da Saúde2000-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700028Memórias do Instituto Oswaldo Cruz v.95 suppl.1 2000reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762000000700028info:eu-repo/semantics/openAccessCastello-Branco,Luiz RROrtigão-de-Sampaio,Maria Beatrizeng2020-04-25T17:48:30Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:10:02.956Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
title Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
spellingShingle Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
Castello-Branco,Luiz RR
gastrointestinal immunology
human immunodeficiency virus-1 infection
nutrition
mucosal immunology
title_short Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
title_full Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
title_fullStr Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
title_full_unstemmed Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
title_sort Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
author Castello-Branco,Luiz RR
author_facet Castello-Branco,Luiz RR
Ortigão-de-Sampaio,Maria Beatriz
author_role author
author2 Ortigão-de-Sampaio,Maria Beatriz
author2_role author
dc.contributor.author.fl_str_mv Castello-Branco,Luiz RR
Ortigão-de-Sampaio,Maria Beatriz
dc.subject.por.fl_str_mv gastrointestinal immunology
human immunodeficiency virus-1 infection
nutrition
mucosal immunology
topic gastrointestinal immunology
human immunodeficiency virus-1 infection
nutrition
mucosal immunology
dc.description.none.fl_txt_mv Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.
description Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.
publishDate 2000
dc.date.none.fl_str_mv 2000-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700028
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762000000700028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.95 suppl.1 2000
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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