High prevalence of drug-resistant tuberculosis and other mycobacteria among HIV-infected patients in Brazil: a systematic review

• Autor(a) principal: Bammann,Ricardo H
• Data de Publicação: 2010
• Outros Autores: Zamarioli,Liliana A, Pinto,Valdir S, Vázquez,Carla MP, Litvoc,Marcelo N, Klautau,Giselle B, Melo,Fernando A Fiúza de, Cavalcante,Nilton J, Ferrazoli,Lucilaine
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Memórias do Instituto Oswaldo Cruz
• Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600019
• topic: acquired immunodeficiency syndrome; tuberculosis; drug; resistant; mycobacterial; atypical; Brazil

There is a little-noticed trend involving human immunodeficiency virus (HIV)-infected patients suspected of having tuberculosis: the triple-treatment regimen recommended in Brazil for years has been potentially ineffective in over 30% of the cases. This proportion may be attributable to drug resistance (to at least 1 drug) and/or to infection with non-tuberculous mycobacteria. This evidence was not disclosed in official statistics, but arose from a systematic review of a few regional studies in which the diagnosis was reliably confirmed by mycobacterial culture. This paper clarifies that there has long been ample evidence for the potential benefits of a four-drug regimen for co-infected patients in Brazil and it reinforces the need for determining the species and drug susceptibility in all positive cultures from HIV-positive patients.