Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Detalhes bibliográficos
Autor(a) principal: Castro Faria Neto,Hugo C
Data de Publicação: 2005
Outros Autores: Stafforini,Diana M, Prescott,Stephen M, Zimmerman,Guy A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900014
Resumo: Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.
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spelling Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolaseplatelet-activating factorplatelet-activating factoracethylhydrolaseinflammatory diseasesepsisPlatelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.Instituto Oswaldo Cruz, Ministério da Saúde2005-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900014Memórias do Instituto Oswaldo Cruz v.100 suppl.1 2005reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762005000900014info:eu-repo/semantics/openAccessCastro Faria Neto,Hugo CStafforini,Diana MPrescott,Stephen MZimmerman,Guy Aeng2020-04-25T17:49:31Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:30.892Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
spellingShingle Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
Castro Faria Neto,Hugo C
platelet-activating factor
platelet-activating factor
acethylhydrolase
inflammatory disease
sepsis
title_short Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_full Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_fullStr Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_full_unstemmed Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
title_sort Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
author Castro Faria Neto,Hugo C
author_facet Castro Faria Neto,Hugo C
Stafforini,Diana M
Prescott,Stephen M
Zimmerman,Guy A
author_role author
author2 Stafforini,Diana M
Prescott,Stephen M
Zimmerman,Guy A
author2_role author
author
author
dc.contributor.author.fl_str_mv Castro Faria Neto,Hugo C
Stafforini,Diana M
Prescott,Stephen M
Zimmerman,Guy A
dc.subject.por.fl_str_mv platelet-activating factor
platelet-activating factor
acethylhydrolase
inflammatory disease
sepsis
topic platelet-activating factor
platelet-activating factor
acethylhydrolase
inflammatory disease
sepsis
dc.description.none.fl_txt_mv Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.
description Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900014
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762005000900014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.100 suppl.1 2005
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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