Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies

Detalhes bibliográficos
Autor(a) principal: Soeiro,Maria de Nazaré C
Data de Publicação: 2009
Outros Autores: Dantas,Andréia P, Daliry,Anissa, Silva,Cristiane F da, Batista,Denise GJ, Souza,Elen M de, Oliveira,Gabriel M, Salomão,Kelly, Batista,Marcos Meuser, Pacheco,Michelle GO, Silva,Patrícia Bernardino da, Santa-Rita,Ricardo M, Barreto,Rubem FS Menna, Boykin,David W, Castro,Solange Lisboa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040
Resumo: Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
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spelling Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studiesTrypanosoma cruziChagas diseaseexperimental chemotherapyaromatic diamidinespropolisN,N-dimethyl-propenaminesnaphthoquinonesChagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.Instituto Oswaldo Cruz, Ministério da Saúde2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040Memórias do Instituto Oswaldo Cruz v.104 suppl.1 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000900040info:eu-repo/semantics/openAccessSoeiro,Maria de Nazaré CDantas,Andréia PDaliry,AnissaSilva,Cristiane F daBatista,Denise GJSouza,Elen M deOliveira,Gabriel MSalomão,KellyBatista,Marcos MeuserPacheco,Michelle GOSilva,Patrícia Bernardino daSanta-Rita,Ricardo MBarreto,Rubem FS MennaBoykin,David WCastro,Solange Lisboa deeng2020-04-25T17:50:38Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:43.693Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
title Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
spellingShingle Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
Soeiro,Maria de Nazaré C
Trypanosoma cruzi
Chagas disease
experimental chemotherapy
aromatic diamidines
propolis
N,N-dimethyl-propenamines
naphthoquinones
title_short Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
title_full Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
title_fullStr Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
title_full_unstemmed Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
title_sort Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
author Soeiro,Maria de Nazaré C
author_facet Soeiro,Maria de Nazaré C
Dantas,Andréia P
Daliry,Anissa
Silva,Cristiane F da
Batista,Denise GJ
Souza,Elen M de
Oliveira,Gabriel M
Salomão,Kelly
Batista,Marcos Meuser
Pacheco,Michelle GO
Silva,Patrícia Bernardino da
Santa-Rita,Ricardo M
Barreto,Rubem FS Menna
Boykin,David W
Castro,Solange Lisboa de
author_role author
author2 Dantas,Andréia P
Daliry,Anissa
Silva,Cristiane F da
Batista,Denise GJ
Souza,Elen M de
Oliveira,Gabriel M
Salomão,Kelly
Batista,Marcos Meuser
Pacheco,Michelle GO
Silva,Patrícia Bernardino da
Santa-Rita,Ricardo M
Barreto,Rubem FS Menna
Boykin,David W
Castro,Solange Lisboa de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soeiro,Maria de Nazaré C
Dantas,Andréia P
Daliry,Anissa
Silva,Cristiane F da
Batista,Denise GJ
Souza,Elen M de
Oliveira,Gabriel M
Salomão,Kelly
Batista,Marcos Meuser
Pacheco,Michelle GO
Silva,Patrícia Bernardino da
Santa-Rita,Ricardo M
Barreto,Rubem FS Menna
Boykin,David W
Castro,Solange Lisboa de
dc.subject.por.fl_str_mv Trypanosoma cruzi
Chagas disease
experimental chemotherapy
aromatic diamidines
propolis
N,N-dimethyl-propenamines
naphthoquinones
topic Trypanosoma cruzi
Chagas disease
experimental chemotherapy
aromatic diamidines
propolis
N,N-dimethyl-propenamines
naphthoquinones
dc.description.none.fl_txt_mv Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
description Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.
publishDate 2009
dc.date.none.fl_str_mv 2009-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762009000900040
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.104 suppl.1 2009
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
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