Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040 |
Resumo: | Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy. |
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Memórias do Instituto Oswaldo Cruz |
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Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studiesTrypanosoma cruziChagas diseaseexperimental chemotherapyaromatic diamidinespropolisN,N-dimethyl-propenaminesnaphthoquinonesChagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.Instituto Oswaldo Cruz, Ministério da Saúde2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040Memórias do Instituto Oswaldo Cruz v.104 suppl.1 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000900040info:eu-repo/semantics/openAccessSoeiro,Maria de Nazaré CDantas,Andréia PDaliry,AnissaSilva,Cristiane F daBatista,Denise GJSouza,Elen M deOliveira,Gabriel MSalomão,KellyBatista,Marcos MeuserPacheco,Michelle GOSilva,Patrícia Bernardino daSanta-Rita,Ricardo MBarreto,Rubem FS MennaBoykin,David WCastro,Solange Lisboa deeng2020-04-25T17:50:38Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:43.693Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
title |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
spellingShingle |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies Soeiro,Maria de Nazaré C Trypanosoma cruzi Chagas disease experimental chemotherapy aromatic diamidines propolis N,N-dimethyl-propenamines naphthoquinones |
title_short |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
title_full |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
title_fullStr |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
title_full_unstemmed |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
title_sort |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies |
author |
Soeiro,Maria de Nazaré C |
author_facet |
Soeiro,Maria de Nazaré C Dantas,Andréia P Daliry,Anissa Silva,Cristiane F da Batista,Denise GJ Souza,Elen M de Oliveira,Gabriel M Salomão,Kelly Batista,Marcos Meuser Pacheco,Michelle GO Silva,Patrícia Bernardino da Santa-Rita,Ricardo M Barreto,Rubem FS Menna Boykin,David W Castro,Solange Lisboa de |
author_role |
author |
author2 |
Dantas,Andréia P Daliry,Anissa Silva,Cristiane F da Batista,Denise GJ Souza,Elen M de Oliveira,Gabriel M Salomão,Kelly Batista,Marcos Meuser Pacheco,Michelle GO Silva,Patrícia Bernardino da Santa-Rita,Ricardo M Barreto,Rubem FS Menna Boykin,David W Castro,Solange Lisboa de |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Soeiro,Maria de Nazaré C Dantas,Andréia P Daliry,Anissa Silva,Cristiane F da Batista,Denise GJ Souza,Elen M de Oliveira,Gabriel M Salomão,Kelly Batista,Marcos Meuser Pacheco,Michelle GO Silva,Patrícia Bernardino da Santa-Rita,Ricardo M Barreto,Rubem FS Menna Boykin,David W Castro,Solange Lisboa de |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi Chagas disease experimental chemotherapy aromatic diamidines propolis N,N-dimethyl-propenamines naphthoquinones |
topic |
Trypanosoma cruzi Chagas disease experimental chemotherapy aromatic diamidines propolis N,N-dimethyl-propenamines naphthoquinones |
dc.description.none.fl_txt_mv |
Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy. |
description |
Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi, is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900040 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762009000900040 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.104 suppl.1 2009 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
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1669937706861330432 |