Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Bittencourt,Achilea Lisboa
Data de Publicação: 1990
Outros Autores: Freitas,Luiz Antonio Rodrigues de, Pompeu,Margarida L., Vieira,Maria Lucia, Barral,Aldina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000100008
Resumo: The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
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spelling Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasisdiffuse cutaneous leishmaniasishuman leishmaniasisLeishmaniaskin biopsieThe authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.Instituto Oswaldo Cruz, Ministério da Saúde1990-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000100008Memórias do Instituto Oswaldo Cruz v.85 n.1 1990reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761990000100008info:eu-repo/semantics/openAccessBittencourt,Achilea LisboaFreitas,Luiz Antonio Rodrigues dePompeu,Margarida L.Vieira,Maria LuciaBarral,Aldinaeng2020-04-25T17:46:28Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:03:38.036Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
title Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
spellingShingle Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
Bittencourt,Achilea Lisboa
diffuse cutaneous leishmaniasis
human leishmaniasis
Leishmania
skin biopsie
title_short Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
title_full Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
title_fullStr Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
title_full_unstemmed Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
title_sort Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
author Bittencourt,Achilea Lisboa
author_facet Bittencourt,Achilea Lisboa
Freitas,Luiz Antonio Rodrigues de
Pompeu,Margarida L.
Vieira,Maria Lucia
Barral,Aldina
author_role author
author2 Freitas,Luiz Antonio Rodrigues de
Pompeu,Margarida L.
Vieira,Maria Lucia
Barral,Aldina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bittencourt,Achilea Lisboa
Freitas,Luiz Antonio Rodrigues de
Pompeu,Margarida L.
Vieira,Maria Lucia
Barral,Aldina
dc.subject.por.fl_str_mv diffuse cutaneous leishmaniasis
human leishmaniasis
Leishmania
skin biopsie
topic diffuse cutaneous leishmaniasis
human leishmaniasis
Leishmania
skin biopsie
dc.description.none.fl_txt_mv The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
description The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
publishDate 1990
dc.date.none.fl_str_mv 1990-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000100008
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761990000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.85 n.1 1990
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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