Schistosoma mansoni: control of female fertility by the male

Detalhes bibliográficos
Autor(a) principal: Kunz,Werner
Data de Publicação: 1995
Outros Autores: Gohr,Lutz, Grevelding,Christoph, Schüssler,Peter, Sommer,Gabriele, Menrath,Marion, Michel,Anja
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010
Resumo: We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.
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spelling Schistosoma mansoni: control of female fertility by the maleSchistosoma mansoniin vitro culturegene expressionmalefemale interactionWe have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.Instituto Oswaldo Cruz, Ministério da Saúde1995-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010Memórias do Instituto Oswaldo Cruz v.90 n.2 1995reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761995000200010info:eu-repo/semantics/openAccessKunz,WernerGohr,LutzGrevelding,ChristophSchüssler,PeterSommer,GabrieleMenrath,MarionMichel,Anjaeng2020-04-25T17:47:23Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:06:26.449Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Schistosoma mansoni: control of female fertility by the male
title Schistosoma mansoni: control of female fertility by the male
spellingShingle Schistosoma mansoni: control of female fertility by the male
Kunz,Werner
Schistosoma mansoni
in vitro culture
gene expression
male
female interaction
title_short Schistosoma mansoni: control of female fertility by the male
title_full Schistosoma mansoni: control of female fertility by the male
title_fullStr Schistosoma mansoni: control of female fertility by the male
title_full_unstemmed Schistosoma mansoni: control of female fertility by the male
title_sort Schistosoma mansoni: control of female fertility by the male
author Kunz,Werner
author_facet Kunz,Werner
Gohr,Lutz
Grevelding,Christoph
Schüssler,Peter
Sommer,Gabriele
Menrath,Marion
Michel,Anja
author_role author
author2 Gohr,Lutz
Grevelding,Christoph
Schüssler,Peter
Sommer,Gabriele
Menrath,Marion
Michel,Anja
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kunz,Werner
Gohr,Lutz
Grevelding,Christoph
Schüssler,Peter
Sommer,Gabriele
Menrath,Marion
Michel,Anja
dc.subject.por.fl_str_mv Schistosoma mansoni
in vitro culture
gene expression
male
female interaction
topic Schistosoma mansoni
in vitro culture
gene expression
male
female interaction
dc.description.none.fl_txt_mv We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.
description We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.
publishDate 1995
dc.date.none.fl_str_mv 1995-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761995000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.90 n.2 1995
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937664052166656

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