Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals

Detalhes bibliográficos
Autor(a) principal: Cordeiro,Rossana de Aguiar
Data de Publicação: 2011
Outros Autores: Astete-Medrano,Delia Jessica, Marques,Francisca Jakelyne de Farias, Andrade,Heuziwanne Tavares Leite, Perdigão Neto,Lauro Vieira, Tavares,Juliane Lira, Lima,Rita Amanda Chaves de, Patoilo,Kharla Kharolyni Nobre Rabelo, Monteiro,Andre Jalles, Brilhante,Raimunda Sâmia Nogueira, Rocha,Marcos Fábio Gadelha, Camargo,Zoilo Pires de, Sidrim,José Júlio Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800024
Resumo: The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
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spelling Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungalsCoccidioides posadasiicotrimoxazoleantifungalssusceptibilityantimicrobial synergismThe aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.Instituto Oswaldo Cruz, Ministério da Saúde2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800024Memórias do Instituto Oswaldo Cruz v.106 n.8 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000800024info:eu-repo/semantics/openAccessCordeiro,Rossana de AguiarAstete-Medrano,Delia JessicaMarques,Francisca Jakelyne de FariasAndrade,Heuziwanne Tavares LeitePerdigão Neto,Lauro VieiraTavares,Juliane LiraLima,Rita Amanda Chaves dePatoilo,Kharla Kharolyni Nobre RabeloMonteiro,Andre JallesBrilhante,Raimunda Sâmia NogueiraRocha,Marcos Fábio GadelhaCamargo,Zoilo Pires deSidrim,José Júlio Costaeng2020-04-25T17:51:05Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:00.505Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
title Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
spellingShingle Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
Cordeiro,Rossana de Aguiar
Coccidioides posadasii
cotrimoxazole
antifungals
susceptibility
antimicrobial synergism
title_short Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
title_full Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
title_fullStr Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
title_full_unstemmed Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
title_sort Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
author Cordeiro,Rossana de Aguiar
author_facet Cordeiro,Rossana de Aguiar
Astete-Medrano,Delia Jessica
Marques,Francisca Jakelyne de Farias
Andrade,Heuziwanne Tavares Leite
Perdigão Neto,Lauro Vieira
Tavares,Juliane Lira
Lima,Rita Amanda Chaves de
Patoilo,Kharla Kharolyni Nobre Rabelo
Monteiro,Andre Jalles
Brilhante,Raimunda Sâmia Nogueira
Rocha,Marcos Fábio Gadelha
Camargo,Zoilo Pires de
Sidrim,José Júlio Costa
author_role author
author2 Astete-Medrano,Delia Jessica
Marques,Francisca Jakelyne de Farias
Andrade,Heuziwanne Tavares Leite
Perdigão Neto,Lauro Vieira
Tavares,Juliane Lira
Lima,Rita Amanda Chaves de
Patoilo,Kharla Kharolyni Nobre Rabelo
Monteiro,Andre Jalles
Brilhante,Raimunda Sâmia Nogueira
Rocha,Marcos Fábio Gadelha
Camargo,Zoilo Pires de
Sidrim,José Júlio Costa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cordeiro,Rossana de Aguiar
Astete-Medrano,Delia Jessica
Marques,Francisca Jakelyne de Farias
Andrade,Heuziwanne Tavares Leite
Perdigão Neto,Lauro Vieira
Tavares,Juliane Lira
Lima,Rita Amanda Chaves de
Patoilo,Kharla Kharolyni Nobre Rabelo
Monteiro,Andre Jalles
Brilhante,Raimunda Sâmia Nogueira
Rocha,Marcos Fábio Gadelha
Camargo,Zoilo Pires de
Sidrim,José Júlio Costa
dc.subject.por.fl_str_mv Coccidioides posadasii
cotrimoxazole
antifungals
susceptibility
antimicrobial synergism
topic Coccidioides posadasii
cotrimoxazole
antifungals
susceptibility
antimicrobial synergism
dc.description.none.fl_txt_mv The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
description The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800024
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000800024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 n.8 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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