Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S0074-02762011000800024 http://repositorio.unifesp.br/handle/11600/6714 |
Resumo: | The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii. |
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Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungalsCoccidioides posadasiicotrimoxazoleantifungalssusceptibilityantimicrobial synergismThe aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.Universidade Federal do Ceará Centro Especializado em Micologia MédicaUniversidade Federal do Ceará Programa de Pós-Graduação em Ciências MédicasUniversidade Federal do Ceará Departamento de QuímicaUniversidade Federal do Ceará Departamento de EstatísticaUniversidade Estadual do Ceará Programa de Pós-Graduação em Ciência VeterináriaUniversidade Federal de São Paulo (UNIFESP) Departamento de Microbiologia, Imunologia e ParasitologiaUNIFESP, Depto. de Microbiologia, Imunologia e ParasitologiaSciELOInstituto Oswaldo Cruz, Ministério da SaúdeUniversidade Federal do Ceará Centro Especializado em Micologia MédicaUniversidade Federal do Ceará Programa de Pós-Graduação em Ciências MédicasUniversidade Federal do Ceará Departamento de QuímicaUniversidade Federal do Ceará Departamento de EstatísticaUniversidade Estadual do Ceará Programa de Pós-Graduação em Ciência VeterináriaUniversidade Federal de São Paulo (UNIFESP)Cordeiro, Rossana de AguiarAstete-Medrano, Delia JessicaMarques, Francisca Jakelyne de FariasAndrade, Heuziwanne Tavares LeitePerdigão Neto, Lauro VieiraTavares, Juliane LiraLima, Rita Amanda Chaves dePatoilo, Kharla Kharolyni Nobre RabeloMonteiro, Andre JallesBrilhante, Raimunda Sâmia NogueiraRocha, Marcos Fábio GadelhaCamargo, Zoilo Pires de [UNIFESP]Sidrim, José Júlio Costa2015-06-14T13:43:22Z2015-06-14T13:43:22Z2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1045-1048application/pdfhttp://dx.doi.org/10.1590/S0074-02762011000800024Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 1045-1048, 2011.10.1590/S0074-02762011000800024S0074-02762011000800024.pdf0074-0276S0074-02762011000800024http://repositorio.unifesp.br/handle/11600/6714WOS:000299068800024engMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T21:08:29Zoai:repositorio.unifesp.br/:11600/6714Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T21:08:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| title |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| spellingShingle |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals Cordeiro, Rossana de Aguiar Coccidioides posadasii cotrimoxazole antifungals susceptibility antimicrobial synergism |
| title_short |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| title_full |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| title_fullStr |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| title_full_unstemmed |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| title_sort |
Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| author |
Cordeiro, Rossana de Aguiar |
| author_facet |
Cordeiro, Rossana de Aguiar Astete-Medrano, Delia Jessica Marques, Francisca Jakelyne de Farias Andrade, Heuziwanne Tavares Leite Perdigão Neto, Lauro Vieira Tavares, Juliane Lira Lima, Rita Amanda Chaves de Patoilo, Kharla Kharolyni Nobre Rabelo Monteiro, Andre Jalles Brilhante, Raimunda Sâmia Nogueira Rocha, Marcos Fábio Gadelha Camargo, Zoilo Pires de [UNIFESP] Sidrim, José Júlio Costa |
| author_role |
author |
| author2 |
Astete-Medrano, Delia Jessica Marques, Francisca Jakelyne de Farias Andrade, Heuziwanne Tavares Leite Perdigão Neto, Lauro Vieira Tavares, Juliane Lira Lima, Rita Amanda Chaves de Patoilo, Kharla Kharolyni Nobre Rabelo Monteiro, Andre Jalles Brilhante, Raimunda Sâmia Nogueira Rocha, Marcos Fábio Gadelha Camargo, Zoilo Pires de [UNIFESP] Sidrim, José Júlio Costa |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal do Ceará Centro Especializado em Micologia Médica Universidade Federal do Ceará Programa de Pós-Graduação em Ciências Médicas Universidade Federal do Ceará Departamento de Química Universidade Federal do Ceará Departamento de Estatística Universidade Estadual do Ceará Programa de Pós-Graduação em Ciência Veterinária Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Cordeiro, Rossana de Aguiar Astete-Medrano, Delia Jessica Marques, Francisca Jakelyne de Farias Andrade, Heuziwanne Tavares Leite Perdigão Neto, Lauro Vieira Tavares, Juliane Lira Lima, Rita Amanda Chaves de Patoilo, Kharla Kharolyni Nobre Rabelo Monteiro, Andre Jalles Brilhante, Raimunda Sâmia Nogueira Rocha, Marcos Fábio Gadelha Camargo, Zoilo Pires de [UNIFESP] Sidrim, José Júlio Costa |
| dc.subject.por.fl_str_mv |
Coccidioides posadasii cotrimoxazole antifungals susceptibility antimicrobial synergism |
| topic |
Coccidioides posadasii cotrimoxazole antifungals susceptibility antimicrobial synergism |
| description |
The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-12-01 2015-06-14T13:43:22Z 2015-06-14T13:43:22Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0074-02762011000800024 Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 1045-1048, 2011. 10.1590/S0074-02762011000800024 S0074-02762011000800024.pdf 0074-0276 S0074-02762011000800024 http://repositorio.unifesp.br/handle/11600/6714 WOS:000299068800024 |
| url |
http://dx.doi.org/10.1590/S0074-02762011000800024 http://repositorio.unifesp.br/handle/11600/6714 |
| identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 1045-1048, 2011. 10.1590/S0074-02762011000800024 S0074-02762011000800024.pdf 0074-0276 S0074-02762011000800024 WOS:000299068800024 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Memórias do Instituto Oswaldo Cruz |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1045-1048 application/pdf |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268284259794944 |