The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Detalhes bibliográficos
Autor(a) principal: Garavito,Giovanny
Data de Publicação: 2012
Outros Autores: Bertani,Stéphane, Quiliano,Miguel, Valentin,Alexis, Aldana,Ignacio, Deharo,Eric
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019
Resumo: The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
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spelling The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinineantimalarialsmethylene bluedrug combinationThe effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.Instituto Oswaldo Cruz, Ministério da Saúde2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019Memórias do Instituto Oswaldo Cruz v.107 n.6 2012reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762012000600019info:eu-repo/semantics/openAccessGaravito,GiovannyBertani,StéphaneQuiliano,MiguelValentin,AlexisAldana,IgnacioDeharo,Ericeng2020-04-25T17:51:17Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:31.86Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
title The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
spellingShingle The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
Garavito,Giovanny
antimalarials
methylene blue
drug combination
title_short The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
title_full The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
title_fullStr The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
title_full_unstemmed The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
title_sort The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
author Garavito,Giovanny
author_facet Garavito,Giovanny
Bertani,Stéphane
Quiliano,Miguel
Valentin,Alexis
Aldana,Ignacio
Deharo,Eric
author_role author
author2 Bertani,Stéphane
Quiliano,Miguel
Valentin,Alexis
Aldana,Ignacio
Deharo,Eric
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Garavito,Giovanny
Bertani,Stéphane
Quiliano,Miguel
Valentin,Alexis
Aldana,Ignacio
Deharo,Eric
dc.subject.por.fl_str_mv antimalarials
methylene blue
drug combination
topic antimalarials
methylene blue
drug combination
dc.description.none.fl_txt_mv The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
description The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
publishDate 2012
dc.date.none.fl_str_mv 2012-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762012000600019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.107 n.6 2012
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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