The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019 |
Resumo: | The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs. |
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Memórias do Instituto Oswaldo Cruz |
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The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinineantimalarialsmethylene bluedrug combinationThe effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.Instituto Oswaldo Cruz, Ministério da Saúde2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019Memórias do Instituto Oswaldo Cruz v.107 n.6 2012reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762012000600019info:eu-repo/semantics/openAccessGaravito,GiovannyBertani,StéphaneQuiliano,MiguelValentin,AlexisAldana,IgnacioDeharo,Ericeng2020-04-25T17:51:17Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:31.86Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
title |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
spellingShingle |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine Garavito,Giovanny antimalarials methylene blue drug combination |
title_short |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
title_full |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
title_fullStr |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
title_full_unstemmed |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
title_sort |
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine |
author |
Garavito,Giovanny |
author_facet |
Garavito,Giovanny Bertani,Stéphane Quiliano,Miguel Valentin,Alexis Aldana,Ignacio Deharo,Eric |
author_role |
author |
author2 |
Bertani,Stéphane Quiliano,Miguel Valentin,Alexis Aldana,Ignacio Deharo,Eric |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Garavito,Giovanny Bertani,Stéphane Quiliano,Miguel Valentin,Alexis Aldana,Ignacio Deharo,Eric |
dc.subject.por.fl_str_mv |
antimalarials methylene blue drug combination |
topic |
antimalarials methylene blue drug combination |
dc.description.none.fl_txt_mv |
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs. |
description |
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000600019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762012000600019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.107 n.6 2012 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937712148250624 |